Mycophenolate mofetil inhibits macrophage infiltration and kidney fibrosis in long-term ischemia–reperfusion injury

Immunosuppressants have been widely used in renal transplantation, in which ischemia–reperfusion injury is inevitable. Mycophenolate mofetil (MMF) is a relative novel immunosuppressant and also attenuates ischemia–reperfusion injury in the acute phase, but its long-term effects are still obscure. Un...

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Veröffentlicht in:	European journal of pharmacology 2012-08, Vol.688 (1-3), p.56-61
Hauptverfasser:	Jiang, Shuai, Tang, Qunye, Rong, Ruiming, Tang, Liangfeng, Xu, Ming, Lu, Jidong, Jia, Yichen, Ooi, YitReen, Hou, Jun, Guo, Jianming, Yang, Bin, Zhu, Tongyu
Format:	Artikel
Sprache:	eng
Schlagworte:	allografting Animals Chemokine CCL2 - metabolism Dose-Response Relationship, Drug Fibrosis flow cytometry Gene Expression Regulation - drug effects immunohistochemistry immunosuppressive agents Immunosuppressive Agents - pharmacology Ischemia–reperfusion injury Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney - physiopathology kidney transplant kidneys long term effects Lymphocytes - drug effects Lymphocytes - immunology Macrophage macrophages Macrophages - drug effects Macrophages - immunology Male MCP-1 (monocyte chemotactic protein‐1) Mycophenolate mofetil Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - pharmacology patients quantitative polymerase chain reaction Rats Rats, Sprague-Dawley renal function Reperfusion Injury - immunology Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - physiopathology secretion TGF-β1 (transforming growth factor beta‐1) Time Factors transforming growth factor beta 1 Transforming Growth Factor beta1 - metabolism
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