Dietary methyl donor depletion protects against intestinal tumorigenesis in Apc(Min/+) mice

Despite recent population data, the influence of dietary folate supplementation on colon cancer risk remains controversial. This study examines the effects of folate deficiency, in combination with choline, methionine, and vitamin B12 depletion, on intestinal tumorigenesis in Apc(Min/+) mice. Methyl...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2012-07, Vol.5 (7), p.911-920
Hauptverfasser:	Kadaveru, Krishna, Protiva, Petr, Greenspan, Emily J, Kim, Young-In, Rosenberg, Daniel W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - genetics Caloric Restriction Diet Folic Acid - administration & dosage Folic Acid Deficiency - genetics Folic Acid Deficiency - pathology Folic Acid Deficiency - prevention & control Gene Expression Profiling Genes, APC - physiology Humans Intestinal Neoplasms - genetics Intestinal Neoplasms - pathology Intestinal Neoplasms - prevention & control Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction
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