Polyamines Detoxify the Anticoagulant Effect of Acetaldehyde on Prothrombin Time

Naturally occurring bioamines, such as putrescine, cadaverine, agmatine, spermidine, and spermine, were tested at pharmacological levels for their capacity to affect prothrombin time (PT). Each of the bioamines tested prolonged PT with decreasing orders of sensitivity being agmatine > spermidine...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2012-07, Vol.60 (1), p.1-7
Hauptverfasser:	Brecher, Arthur S, Riaz, Anum H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde - toxicity Anticoagulants - toxicity Dose-Response Relationship, Drug Ethanol - metabolism Humans Polyamines - administration & dosage Polyamines - pharmacology Prothrombin Time Temperature Time Factors
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