Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors
The factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during...
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| Veröffentlicht in: | Hypertension research 2012-07, Vol.35 (7), p.733-738 |
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| creator | de Lima, Sandro G de Albuquerque, Maria de F P M de Oliveira, João R M Ayres, Constância F J da Cunha, José E G de Oliveira, Danyllo F de Lemos, Roberta R de Souza, Manuela B R e Silva, Odwaldo B |
| description | The factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10,027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P=0.002 and |
| doi_str_mv | 10.1038/hr.2012.14 |
| format | Article |
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The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10,027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P=0.002 and <0.001, respectively). No association was observed between the polymorphisms cited above and EBPR. An analysis of the joint effect of variables has indicated that only age (P< 0.001) and BMI (P=0.001) were specifically associated with systolic BP during exercise. Age and BMI were the only factors that independently influenced EBPR during ETT.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/hr.2012.14</identifier><identifier>PMID: 22357524</identifier><language>eng</language><publisher>England</publisher><subject>Adolescent ; Adult ; Aged ; Angiotensinogen - genetics ; Blood Pressure - genetics ; Blood Pressure - physiology ; Cohort Studies ; Exercise Test ; Female ; Genetic Association Studies ; Hemodynamics - genetics ; Hemodynamics - physiology ; Humans ; Hypertension - genetics ; Hypertension - physiopathology ; INDEL Mutation ; Male ; Middle Aged ; Peptidyl-Dipeptidase A - genetics ; Polymorphism, Genetic ; Risk Factors ; Young Adult</subject><ispartof>Hypertension research, 2012-07, Vol.35 (7), p.733-738</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-b18053c470ea91925e76024796cdb3ae7df401ddea9270c4ed6f055d818915ad3</citedby><cites>FETCH-LOGICAL-c442t-b18053c470ea91925e76024796cdb3ae7df401ddea9270c4ed6f055d818915ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22357524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Lima, Sandro G</creatorcontrib><creatorcontrib>de Albuquerque, Maria de F P M</creatorcontrib><creatorcontrib>de Oliveira, João R M</creatorcontrib><creatorcontrib>Ayres, Constância F J</creatorcontrib><creatorcontrib>da Cunha, José E G</creatorcontrib><creatorcontrib>de Oliveira, Danyllo F</creatorcontrib><creatorcontrib>de Lemos, Roberta R</creatorcontrib><creatorcontrib>de Souza, Manuela B R</creatorcontrib><creatorcontrib>e Silva, Odwaldo B</creatorcontrib><title>Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>The factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10,027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P=0.002 and <0.001, respectively). No association was observed between the polymorphisms cited above and EBPR. An analysis of the joint effect of variables has indicated that only age (P< 0.001) and BMI (P=0.001) were specifically associated with systolic BP during exercise. Age and BMI were the only factors that independently influenced EBPR during ETT.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Angiotensinogen - genetics</subject><subject>Blood Pressure - genetics</subject><subject>Blood Pressure - physiology</subject><subject>Cohort Studies</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Hemodynamics - genetics</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Hypertension - genetics</subject><subject>Hypertension - physiopathology</subject><subject>INDEL Mutation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotlY3_gDJUsSpuZnMy52U-oCCG10PmeROOzozqUkGWvDHm9rq6nA5Hx-XQ8glsCmwOL9b2SlnwKcgjsgYYpFHgoM4JmNWQBoVaZyOyJlzH4zxPCnglIw4j5Ms4WJMvucbuVyilR41rVpjNF1bdG6wSEOuTe-Q6sE2_ZLiBq1qwu0tSt01bUs9Oh-qe1oPvfKN6WVLZa_pCjujt73sGkVrlD7o3O1vYxv3SWupvLHunJzUsnV4ccgJeX-cv82eo8Xr08vsYREpIbiPKshZEiuRMZQFFDzBLGVcZEWqdBVLzHQtGGgdWp4xJVCnNUsSnUNeQCJ1PCHXe-_amq8hvFx2jVPYtrJHM7gSgg0YMJYH9GaPKmucs1iXa9t00m4DVO7WLle23K1dggjw1cE7VB3qf_Rv3vgH0QV8ww</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>de Lima, Sandro G</creator><creator>de Albuquerque, Maria de F P M</creator><creator>de Oliveira, João R M</creator><creator>Ayres, Constância F J</creator><creator>da Cunha, José E G</creator><creator>de Oliveira, Danyllo F</creator><creator>de Lemos, Roberta R</creator><creator>de Souza, Manuela B R</creator><creator>e Silva, Odwaldo B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors</title><author>de Lima, Sandro G ; de Albuquerque, Maria de F P M ; de Oliveira, João R M ; Ayres, Constância F J ; da Cunha, José E G ; de Oliveira, Danyllo F ; de Lemos, Roberta R ; de Souza, Manuela B R ; e Silva, Odwaldo B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-b18053c470ea91925e76024796cdb3ae7df401ddea9270c4ed6f055d818915ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Angiotensinogen - genetics</topic><topic>Blood Pressure - genetics</topic><topic>Blood Pressure - physiology</topic><topic>Cohort Studies</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Hemodynamics - genetics</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Hypertension - genetics</topic><topic>Hypertension - physiopathology</topic><topic>INDEL Mutation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Lima, Sandro G</creatorcontrib><creatorcontrib>de Albuquerque, Maria de F P M</creatorcontrib><creatorcontrib>de Oliveira, João R M</creatorcontrib><creatorcontrib>Ayres, Constância F J</creatorcontrib><creatorcontrib>da Cunha, José E G</creatorcontrib><creatorcontrib>de Oliveira, Danyllo F</creatorcontrib><creatorcontrib>de Lemos, Roberta R</creatorcontrib><creatorcontrib>de Souza, Manuela B R</creatorcontrib><creatorcontrib>e Silva, Odwaldo B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Lima, Sandro G</au><au>de Albuquerque, Maria de F P M</au><au>de Oliveira, João R M</au><au>Ayres, Constância F J</au><au>da Cunha, José E G</au><au>de Oliveira, Danyllo F</au><au>de Lemos, Roberta R</au><au>de Souza, Manuela B R</au><au>e Silva, Odwaldo B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>35</volume><issue>7</issue><spage>733</spage><epage>738</epage><pages>733-738</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>The factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10,027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P=0.002 and <0.001, respectively). No association was observed between the polymorphisms cited above and EBPR. An analysis of the joint effect of variables has indicated that only age (P< 0.001) and BMI (P=0.001) were specifically associated with systolic BP during exercise. Age and BMI were the only factors that independently influenced EBPR during ETT.</abstract><cop>England</cop><pmid>22357524</pmid><doi>10.1038/hr.2012.14</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Angiotensinogen - genetics Blood Pressure - genetics Blood Pressure - physiology Cohort Studies Exercise Test Female Genetic Association Studies Hemodynamics - genetics Hemodynamics - physiology Humans Hypertension - genetics Hypertension - physiopathology INDEL Mutation Male Middle Aged Peptidyl-Dipeptidase A - genetics Polymorphism, Genetic Risk Factors Young Adult |
| title | Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors |
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