Effects of Long‐Pulsed 1,064‐nm Neodymium‐Doped Yttrium Aluminum Garnet Laser on Dermal Collagen Remodeling in Hairless Mice
Background Nonablative lasers are used for dermal collagen remodeling. Although clinical improvements have been reported using various laser devices, the mechanism of dermal collagen remodeling remains unknown. Objective To investigate the effects of energy fluences of the long‐pulsed neodymium‐dope...
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| Veröffentlicht in: | Dermatologic surgery 2012-07, Vol.38 (7pt1), p.985-992 |
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| creator | Lee, Young Bok Kang, Na Hyeon Eun, Young Sun Cheon, Min Seok Kim, Kyung Moon Cho, Baik Kee Park, Hyun Jeong |
| description | Background
Nonablative lasers are used for dermal collagen remodeling. Although clinical improvements have been reported using various laser devices, the mechanism of dermal collagen remodeling remains unknown.
Objective
To investigate the effects of energy fluences of the long‐pulsed neodymium‐doped yttrium aluminum garnet (Nd:YAG) nonablative laser on dermal collagen remodeling and evaluate the dermal collagen remodeling mechanism.
Materials and methods
Hairless mice were pretreated with ultraviolet B irradiation to produce photo‐damage. The laser treatment used a long‐pulse 1,064‐nm Nd:YAG laser at energy fluences of 20, 40, and 60 J/cm2. The amount of dermal collagen and expressions of transforming growth factor beta (TGF‐β), matrix metalloproteinase‐1 (MMP‐1), and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) of laser treated skin were compared with those of nontreated control skin.
Results
The long‐pulse Nd:YAG laser treatment increased dermal collagen and significantly increased TGF‐β expression. The expression of MMP‐1 decreased with low energy fluence. The expression of TIMP‐1was not significantly different.
Conclusion
Long‐pulsed 1,064‐nm Nd:YAG laser increases the dermal collagen in association with the increased expression of TGF‐β. |
| doi_str_mv | 10.1111/j.1524-4725.2012.02374.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1024099762</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1024099762</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3994-ffe7fd2579f969cd30b6a1f88739079c5fb9d2b212e53adff77ccc928cdd7d803</originalsourceid><addsrcrecordid>eNqNkcmOEzEQhi0EYhZ4BeQLEge6sd2L2wcOo2SYQQqLgDlwshwvkSMvwe4Wk9uIJ-AZeRLcJAxXfHH9qq8W_QUAxKjG5b3a1rgjbdVS0tUEYVIj0tC2vn0ATu8TD0uMaF-hDpMTcJbzFhWSNegxOCGkRS0h_Sn4cWmMlmOG0cBVDJtfdz8_Ti5rBfFL1LdFBg_f66j23k6-yGXcleTXcUxFwws3eRtKcCVS0CNciawTjAEudfLCwUV0Tmx0gJ-0j0o7GzbQBngtbHI6Z_jOSv0EPDKijHx6_M_BzZvLL4vravXh6u3iYlXJhrG2KntSo0hHmWE9k6pB615gMwy0YYgy2Zk1U2RNMNFdI5QxlEopGRmkUlQNqDkHLw59dyl-m3QeubdZ6rJg0HHKHKPiCmO0JwUdDqhMMeekDd8l60XaF4jPF-BbPhvNZ6P5fAH-5wL8tpQ-O06Z1l6r-8K_lhfg-REQWQpnkgjS5n9cjwfE2q5wrw_cd-v0_r8X4MvPN3PU_AZT1qSg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1024099762</pqid></control><display><type>article</type><title>Effects of Long‐Pulsed 1,064‐nm Neodymium‐Doped Yttrium Aluminum Garnet Laser on Dermal Collagen Remodeling in Hairless Mice</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Access via Wiley Online Library</source><creator>Lee, Young Bok ; Kang, Na Hyeon ; Eun, Young Sun ; Cheon, Min Seok ; Kim, Kyung Moon ; Cho, Baik Kee ; Park, Hyun Jeong</creator><creatorcontrib>Lee, Young Bok ; Kang, Na Hyeon ; Eun, Young Sun ; Cheon, Min Seok ; Kim, Kyung Moon ; Cho, Baik Kee ; Park, Hyun Jeong</creatorcontrib><description>Background
Nonablative lasers are used for dermal collagen remodeling. Although clinical improvements have been reported using various laser devices, the mechanism of dermal collagen remodeling remains unknown.
Objective
To investigate the effects of energy fluences of the long‐pulsed neodymium‐doped yttrium aluminum garnet (Nd:YAG) nonablative laser on dermal collagen remodeling and evaluate the dermal collagen remodeling mechanism.
Materials and methods
Hairless mice were pretreated with ultraviolet B irradiation to produce photo‐damage. The laser treatment used a long‐pulse 1,064‐nm Nd:YAG laser at energy fluences of 20, 40, and 60 J/cm2. The amount of dermal collagen and expressions of transforming growth factor beta (TGF‐β), matrix metalloproteinase‐1 (MMP‐1), and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) of laser treated skin were compared with those of nontreated control skin.
Results
The long‐pulse Nd:YAG laser treatment increased dermal collagen and significantly increased TGF‐β expression. The expression of MMP‐1 decreased with low energy fluence. The expression of TIMP‐1was not significantly different.
Conclusion
Long‐pulsed 1,064‐nm Nd:YAG laser increases the dermal collagen in association with the increased expression of TGF‐β.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1111/j.1524-4725.2012.02374.x</identifier><identifier>PMID: 22404226</identifier><language>eng</language><publisher>Malden, MA: Wiley</publisher><subject>Animals ; Biological and medical sciences ; Collagen - metabolism ; Collagen - radiation effects ; Dermatology ; Lasers, Semiconductor - therapeutic use ; Male ; Matrix Metalloproteinase 1 - genetics ; Matrix Metalloproteinase 1 - metabolism ; Medical sciences ; Mice ; Mice, Hairless ; Models, Animal ; Rejuvenation ; RNA, Messenger - metabolism ; Skin - metabolism ; Skin - pathology ; Skin - radiation effects ; Skin Aging - pathology ; Skin Aging - radiation effects ; Skin plastic surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue Inhibitor of Metalloproteinase-1 - genetics ; Tissue Inhibitor of Metalloproteinase-1 - metabolism ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - metabolism ; Ultraviolet Rays - adverse effects</subject><ispartof>Dermatologic surgery, 2012-07, Vol.38 (7pt1), p.985-992</ispartof><rights>2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3994-ffe7fd2579f969cd30b6a1f88739079c5fb9d2b212e53adff77ccc928cdd7d803</citedby><cites>FETCH-LOGICAL-c3994-ffe7fd2579f969cd30b6a1f88739079c5fb9d2b212e53adff77ccc928cdd7d803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4725.2012.02374.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4725.2012.02374.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26180945$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22404226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Young Bok</creatorcontrib><creatorcontrib>Kang, Na Hyeon</creatorcontrib><creatorcontrib>Eun, Young Sun</creatorcontrib><creatorcontrib>Cheon, Min Seok</creatorcontrib><creatorcontrib>Kim, Kyung Moon</creatorcontrib><creatorcontrib>Cho, Baik Kee</creatorcontrib><creatorcontrib>Park, Hyun Jeong</creatorcontrib><title>Effects of Long‐Pulsed 1,064‐nm Neodymium‐Doped Yttrium Aluminum Garnet Laser on Dermal Collagen Remodeling in Hairless Mice</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>Background
Nonablative lasers are used for dermal collagen remodeling. Although clinical improvements have been reported using various laser devices, the mechanism of dermal collagen remodeling remains unknown.
Objective
To investigate the effects of energy fluences of the long‐pulsed neodymium‐doped yttrium aluminum garnet (Nd:YAG) nonablative laser on dermal collagen remodeling and evaluate the dermal collagen remodeling mechanism.
Materials and methods
Hairless mice were pretreated with ultraviolet B irradiation to produce photo‐damage. The laser treatment used a long‐pulse 1,064‐nm Nd:YAG laser at energy fluences of 20, 40, and 60 J/cm2. The amount of dermal collagen and expressions of transforming growth factor beta (TGF‐β), matrix metalloproteinase‐1 (MMP‐1), and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) of laser treated skin were compared with those of nontreated control skin.
Results
The long‐pulse Nd:YAG laser treatment increased dermal collagen and significantly increased TGF‐β expression. The expression of MMP‐1 decreased with low energy fluence. The expression of TIMP‐1was not significantly different.
Conclusion
Long‐pulsed 1,064‐nm Nd:YAG laser increases the dermal collagen in association with the increased expression of TGF‐β.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Collagen - metabolism</subject><subject>Collagen - radiation effects</subject><subject>Dermatology</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Male</subject><subject>Matrix Metalloproteinase 1 - genetics</subject><subject>Matrix Metalloproteinase 1 - metabolism</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Hairless</subject><subject>Models, Animal</subject><subject>Rejuvenation</subject><subject>RNA, Messenger - metabolism</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><subject>Skin - radiation effects</subject><subject>Skin Aging - pathology</subject><subject>Skin Aging - radiation effects</subject><subject>Skin plastic surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - genetics</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - metabolism</subject><subject>Transforming Growth Factor beta - genetics</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Ultraviolet Rays - adverse effects</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcmOEzEQhi0EYhZ4BeQLEge6sd2L2wcOo2SYQQqLgDlwshwvkSMvwe4Wk9uIJ-AZeRLcJAxXfHH9qq8W_QUAxKjG5b3a1rgjbdVS0tUEYVIj0tC2vn0ATu8TD0uMaF-hDpMTcJbzFhWSNegxOCGkRS0h_Sn4cWmMlmOG0cBVDJtfdz8_Ti5rBfFL1LdFBg_f66j23k6-yGXcleTXcUxFwws3eRtKcCVS0CNciawTjAEudfLCwUV0Tmx0gJ-0j0o7GzbQBngtbHI6Z_jOSv0EPDKijHx6_M_BzZvLL4vravXh6u3iYlXJhrG2KntSo0hHmWE9k6pB615gMwy0YYgy2Zk1U2RNMNFdI5QxlEopGRmkUlQNqDkHLw59dyl-m3QeubdZ6rJg0HHKHKPiCmO0JwUdDqhMMeekDd8l60XaF4jPF-BbPhvNZ6P5fAH-5wL8tpQ-O06Z1l6r-8K_lhfg-REQWQpnkgjS5n9cjwfE2q5wrw_cd-v0_r8X4MvPN3PU_AZT1qSg</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Lee, Young Bok</creator><creator>Kang, Na Hyeon</creator><creator>Eun, Young Sun</creator><creator>Cheon, Min Seok</creator><creator>Kim, Kyung Moon</creator><creator>Cho, Baik Kee</creator><creator>Park, Hyun Jeong</creator><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>Effects of Long‐Pulsed 1,064‐nm Neodymium‐Doped Yttrium Aluminum Garnet Laser on Dermal Collagen Remodeling in Hairless Mice</title><author>Lee, Young Bok ; Kang, Na Hyeon ; Eun, Young Sun ; Cheon, Min Seok ; Kim, Kyung Moon ; Cho, Baik Kee ; Park, Hyun Jeong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3994-ffe7fd2579f969cd30b6a1f88739079c5fb9d2b212e53adff77ccc928cdd7d803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Collagen - metabolism</topic><topic>Collagen - radiation effects</topic><topic>Dermatology</topic><topic>Lasers, Semiconductor - therapeutic use</topic><topic>Male</topic><topic>Matrix Metalloproteinase 1 - genetics</topic><topic>Matrix Metalloproteinase 1 - metabolism</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Hairless</topic><topic>Models, Animal</topic><topic>Rejuvenation</topic><topic>RNA, Messenger - metabolism</topic><topic>Skin - metabolism</topic><topic>Skin - pathology</topic><topic>Skin - radiation effects</topic><topic>Skin Aging - pathology</topic><topic>Skin Aging - radiation effects</topic><topic>Skin plastic surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - genetics</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - metabolism</topic><topic>Transforming Growth Factor beta - genetics</topic><topic>Transforming Growth Factor beta - metabolism</topic><topic>Ultraviolet Rays - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Young Bok</creatorcontrib><creatorcontrib>Kang, Na Hyeon</creatorcontrib><creatorcontrib>Eun, Young Sun</creatorcontrib><creatorcontrib>Cheon, Min Seok</creatorcontrib><creatorcontrib>Kim, Kyung Moon</creatorcontrib><creatorcontrib>Cho, Baik Kee</creatorcontrib><creatorcontrib>Park, Hyun Jeong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Young Bok</au><au>Kang, Na Hyeon</au><au>Eun, Young Sun</au><au>Cheon, Min Seok</au><au>Kim, Kyung Moon</au><au>Cho, Baik Kee</au><au>Park, Hyun Jeong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Long‐Pulsed 1,064‐nm Neodymium‐Doped Yttrium Aluminum Garnet Laser on Dermal Collagen Remodeling in Hairless Mice</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2012-07</date><risdate>2012</risdate><volume>38</volume><issue>7pt1</issue><spage>985</spage><epage>992</epage><pages>985-992</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>Background
Nonablative lasers are used for dermal collagen remodeling. Although clinical improvements have been reported using various laser devices, the mechanism of dermal collagen remodeling remains unknown.
Objective
To investigate the effects of energy fluences of the long‐pulsed neodymium‐doped yttrium aluminum garnet (Nd:YAG) nonablative laser on dermal collagen remodeling and evaluate the dermal collagen remodeling mechanism.
Materials and methods
Hairless mice were pretreated with ultraviolet B irradiation to produce photo‐damage. The laser treatment used a long‐pulse 1,064‐nm Nd:YAG laser at energy fluences of 20, 40, and 60 J/cm2. The amount of dermal collagen and expressions of transforming growth factor beta (TGF‐β), matrix metalloproteinase‐1 (MMP‐1), and tissue inhibitor of metalloproteinase‐1 (TIMP‐1) of laser treated skin were compared with those of nontreated control skin.
Results
The long‐pulse Nd:YAG laser treatment increased dermal collagen and significantly increased TGF‐β expression. The expression of MMP‐1 decreased with low energy fluence. The expression of TIMP‐1was not significantly different.
Conclusion
Long‐pulsed 1,064‐nm Nd:YAG laser increases the dermal collagen in association with the increased expression of TGF‐β.</abstract><cop>Malden, MA</cop><pub>Wiley</pub><pmid>22404226</pmid><doi>10.1111/j.1524-4725.2012.02374.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Dermatologic surgery, 2012-07, Vol.38 (7pt1), p.985-992 |
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| subjects | Animals Biological and medical sciences Collagen - metabolism Collagen - radiation effects Dermatology Lasers, Semiconductor - therapeutic use Male Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Medical sciences Mice Mice, Hairless Models, Animal Rejuvenation RNA, Messenger - metabolism Skin - metabolism Skin - pathology Skin - radiation effects Skin Aging - pathology Skin Aging - radiation effects Skin plastic surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Ultraviolet Rays - adverse effects |
| title | Effects of Long‐Pulsed 1,064‐nm Neodymium‐Doped Yttrium Aluminum Garnet Laser on Dermal Collagen Remodeling in Hairless Mice |
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