The Comparability of In Vitro and Ex Vivo Studies on the Percutaneous Permeation of Topical Formulations Containing Ibuprofen

In order to avoid in vivo experiments and to gain information about the suitability of surrogates for skin replacement, Franz-type diffusion cell experiments were conducted by using three ibuprofen-containing formulations (cream, gel and microgel) on bovine split-skin samples and cellophane membrane...

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Veröffentlicht in:	Alternatives to laboratory animals 2012-05, Vol.40 (2), p.91-98
Hauptverfasser:	STAHL, Jessica, BLUME, Bettina, BIENAS, Silvia, KIETZMANN, Manfred
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Biological and medical sciences Cattle Chemistry, Pharmaceutical Ibuprofen - administration & dosage Ibuprofen - pharmacokinetics Medical sciences Permeability Skin Absorption Toxicology
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