Solid-Phase Synthesis of γ-AApeptides Using a Submonomeric Approach

The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2012-07, Vol.14 (13), p.3446-3449
Hauptverfasser:	Wu, Haifan, Amin, Mohamad Nassir, Niu, Youhong, Qiao, Qiao, Harfouch, Nassier, Nimer, Abdelfattah, Cai, Jianfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Molecular Structure Peptides - chemical synthesis Peptides - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	3449
container_issue	13
container_start_page	3446
container_title	Organic letters
container_volume	14
creator	Wu, Haifan Amin, Mohamad Nassir Niu, Youhong Qiao, Qiao Harfouch, Nassier Nimer, Abdelfattah Cai, Jianfeng
description	The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential of developing chemically diverse γ-AApeptide libraries and thereby facilitate the biological applications of γ-AApeptides in the future.
doi_str_mv	10.1021/ol301406a
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1024096684</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1024096684</sourcerecordid><originalsourceid>FETCH-LOGICAL-a315t-d2a661d2c29b83fccd13e41788f088cd9cfec62484ac624fa342b4f119fc4d4d3</originalsourceid><addsrcrecordid>eNpt0LtOwzAUBmALgWgpDLwA8oIEQ8C3Os4YlatUCaTSOXJ9oamSONjJ0OfiPXgmXKV0YjpH1qffOj8AlxjdYUTwvasowgxxeQTGeEpokqIpOT7sHI3AWQgbhHB8yU7BiJCUYp6KMXhYuKrUyftaBgMX26Zbm1AG6Cz8-U7yvDVtV2oT4DKUzSeUcNGvate42vhSwbxtvZNqfQ5OrKyCudjPCVg-PX7MXpL52_PrLJ8nkuJpl2giOceaKJKtBLVKaUwNw6kQFgmhdKasUZwwweRuWEkZWTGLcWYV00zTCbgZcuO3X70JXVGXQZmqko1xfShiGQxlnAsW6e1AlXcheGOL1pe19NuIdg4Xh9KivdrHxuOMPsi_liK4HoBUodi43jfxyn-CfgGs9XMA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1024096684</pqid></control><display><type>article</type><title>Solid-Phase Synthesis of γ-AApeptides Using a Submonomeric Approach</title><source>ACS Publications</source><source>MEDLINE</source><creator>Wu, Haifan ; Amin, Mohamad Nassir ; Niu, Youhong ; Qiao, Qiao ; Harfouch, Nassier ; Nimer, Abdelfattah ; Cai, Jianfeng</creator><creatorcontrib>Wu, Haifan ; Amin, Mohamad Nassir ; Niu, Youhong ; Qiao, Qiao ; Harfouch, Nassier ; Nimer, Abdelfattah ; Cai, Jianfeng</creatorcontrib><description>The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential of developing chemically diverse γ-AApeptide libraries and thereby facilitate the biological applications of γ-AApeptides in the future.</description><identifier>ISSN: 1523-7060</identifier><identifier>EISSN: 1523-7052</identifier><identifier>DOI: 10.1021/ol301406a</identifier><identifier>PMID: 22731678</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Molecular Structure ; Peptides - chemical synthesis ; Peptides - chemistry</subject><ispartof>Organic letters, 2012-07, Vol.14 (13), p.3446-3449</ispartof><rights>Copyright © 2012 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a315t-d2a661d2c29b83fccd13e41788f088cd9cfec62484ac624fa342b4f119fc4d4d3</citedby><cites>FETCH-LOGICAL-a315t-d2a661d2c29b83fccd13e41788f088cd9cfec62484ac624fa342b4f119fc4d4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/ol301406a$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/ol301406a$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22731678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Haifan</creatorcontrib><creatorcontrib>Amin, Mohamad Nassir</creatorcontrib><creatorcontrib>Niu, Youhong</creatorcontrib><creatorcontrib>Qiao, Qiao</creatorcontrib><creatorcontrib>Harfouch, Nassier</creatorcontrib><creatorcontrib>Nimer, Abdelfattah</creatorcontrib><creatorcontrib>Cai, Jianfeng</creatorcontrib><title>Solid-Phase Synthesis of γ-AApeptides Using a Submonomeric Approach</title><title>Organic letters</title><addtitle>Org. Lett</addtitle><description>The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential of developing chemically diverse γ-AApeptide libraries and thereby facilitate the biological applications of γ-AApeptides in the future.</description><subject>Molecular Structure</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - chemistry</subject><issn>1523-7060</issn><issn>1523-7052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0LtOwzAUBmALgWgpDLwA8oIEQ8C3Os4YlatUCaTSOXJ9oamSONjJ0OfiPXgmXKV0YjpH1qffOj8AlxjdYUTwvasowgxxeQTGeEpokqIpOT7sHI3AWQgbhHB8yU7BiJCUYp6KMXhYuKrUyftaBgMX26Zbm1AG6Cz8-U7yvDVtV2oT4DKUzSeUcNGvate42vhSwbxtvZNqfQ5OrKyCudjPCVg-PX7MXpL52_PrLJ8nkuJpl2giOceaKJKtBLVKaUwNw6kQFgmhdKasUZwwweRuWEkZWTGLcWYV00zTCbgZcuO3X70JXVGXQZmqko1xfShiGQxlnAsW6e1AlXcheGOL1pe19NuIdg4Xh9KivdrHxuOMPsi_liK4HoBUodi43jfxyn-CfgGs9XMA</recordid><startdate>20120706</startdate><enddate>20120706</enddate><creator>Wu, Haifan</creator><creator>Amin, Mohamad Nassir</creator><creator>Niu, Youhong</creator><creator>Qiao, Qiao</creator><creator>Harfouch, Nassier</creator><creator>Nimer, Abdelfattah</creator><creator>Cai, Jianfeng</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120706</creationdate><title>Solid-Phase Synthesis of γ-AApeptides Using a Submonomeric Approach</title><author>Wu, Haifan ; Amin, Mohamad Nassir ; Niu, Youhong ; Qiao, Qiao ; Harfouch, Nassier ; Nimer, Abdelfattah ; Cai, Jianfeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a315t-d2a661d2c29b83fccd13e41788f088cd9cfec62484ac624fa342b4f119fc4d4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Molecular Structure</topic><topic>Peptides - chemical synthesis</topic><topic>Peptides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Haifan</creatorcontrib><creatorcontrib>Amin, Mohamad Nassir</creatorcontrib><creatorcontrib>Niu, Youhong</creatorcontrib><creatorcontrib>Qiao, Qiao</creatorcontrib><creatorcontrib>Harfouch, Nassier</creatorcontrib><creatorcontrib>Nimer, Abdelfattah</creatorcontrib><creatorcontrib>Cai, Jianfeng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Organic letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Haifan</au><au>Amin, Mohamad Nassir</au><au>Niu, Youhong</au><au>Qiao, Qiao</au><au>Harfouch, Nassier</au><au>Nimer, Abdelfattah</au><au>Cai, Jianfeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Solid-Phase Synthesis of γ-AApeptides Using a Submonomeric Approach</atitle><jtitle>Organic letters</jtitle><addtitle>Org. Lett</addtitle><date>2012-07-06</date><risdate>2012</risdate><volume>14</volume><issue>13</issue><spage>3446</spage><epage>3449</epage><pages>3446-3449</pages><issn>1523-7060</issn><eissn>1523-7052</eissn><abstract>The solid-phase synthesis of γ-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing γ-AApeptide building blocks in order to prepare γ-AApeptide sequences. This method will maximize the potential of developing chemically diverse γ-AApeptide libraries and thereby facilitate the biological applications of γ-AApeptides in the future.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>22731678</pmid><doi>10.1021/ol301406a</doi><tpages>4</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 1523-7060
ispartof	Organic letters, 2012-07, Vol.14 (13), p.3446-3449
issn	1523-7060 1523-7052
language	eng
recordid	cdi_proquest_miscellaneous_1024096684
source	ACS Publications; MEDLINE
subjects	Molecular Structure Peptides - chemical synthesis Peptides - chemistry
title	Solid-Phase Synthesis of γ-AApeptides Using a Submonomeric Approach
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T04%3A46%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Solid-Phase%20Synthesis%20of%20%CE%B3-AApeptides%20Using%20a%20Submonomeric%20Approach&rft.jtitle=Organic%20letters&rft.au=Wu,%20Haifan&rft.date=2012-07-06&rft.volume=14&rft.issue=13&rft.spage=3446&rft.epage=3449&rft.pages=3446-3449&rft.issn=1523-7060&rft.eissn=1523-7052&rft_id=info:doi/10.1021/ol301406a&rft_dat=%3Cproquest_cross%3E1024096684%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1024096684&rft_id=info:pmid/22731678&rfr_iscdi=true