Forsythoside B Protects Against Experimental Sepsis by Modulating Inflammatory Factors

The present study investigated the effects of Forsythoside B on an experimental model of sepsis induced by caecal ligation and puncture (CLP) in rats and elucidated the potential mechanism in cultured RAW 264.7 cells. Results showed that Forsythoside B concentration‐dependently down‐regulated the le...

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Veröffentlicht in:	Phytotherapy research 2012-07, Vol.26 (7), p.981-987
Hauptverfasser:	Jiang, Wang-Lin, Yong-Xu, Zhang, Shu-Ping, Zhu, Hai-Bo, Jian-Hou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences caecal ligation and puncture Caffeic Acids - pharmacology Cell Line Forsythoside B General pharmacology Glucosides - pharmacology HMGB1 Protein - metabolism I-kappa B Kinase - metabolism IL-10 Imipenem - pharmacology Inflammation Mediators - metabolism Interleukin-10 - blood Interleukin-6 - metabolism Intestine, Small - drug effects Lipopolysaccharides - pharmacology Liver - drug effects Lung - drug effects Male Medical sciences Mice NF-kappa B - metabolism NF-κB Peroxidase - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptors, Immunologic - metabolism Sepsis - drug therapy septic shock triggering receptor expressed on myeloid cells Triggering Receptor Expressed on Myeloid Cells-1 Tumor Necrosis Factor-alpha - metabolism
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