Endometrial Abnormality in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo-...
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| Veröffentlicht in: | Reproductive Sciences 2012-07, Vol.19 (7), p.674-683 |
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| creator | Shang, Kewei Jia, Xiao Qiao, Jie Kang, Jihong Guan, Youfei |
| description | Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo- or anovulation combined with hyperandrogenism. With the higher rate of implantation failure after induction of ovulation or higher risk of spontaneous miscarriage after pregnancy, the reduced fertility is apparently attributed not only to anovulation but also to endometrial dysfunction in patients with PCOS. Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS. |
| doi_str_mv | 10.1177/1933719111430993 |
| format | Article |
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Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo- or anovulation combined with hyperandrogenism. With the higher rate of implantation failure after induction of ovulation or higher risk of spontaneous miscarriage after pregnancy, the reduced fertility is apparently attributed not only to anovulation but also to endometrial dysfunction in patients with PCOS. Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS.</description><identifier>ISSN: 1933-7191</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1177/1933719111430993</identifier><identifier>PMID: 22534323</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Animals ; Biological and medical sciences ; Embryology ; Endometrial Neoplasms - etiology ; Endometrial Neoplasms - prevention & control ; Endometrium - drug effects ; Endometrium - metabolism ; Endometrium - physiopathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Female - etiology ; Infertility, Female - prevention & control ; Medical sciences ; Medicine & Public Health ; Molecular Targeted Therapy ; Non tumoral diseases ; Obstetrics/Perinatology/Midwifery ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - metabolism ; Polycystic Ovary Syndrome - physiopathology ; Receptors, Steroid - agonists ; Receptors, Steroid - antagonists & inhibitors ; Receptors, Steroid - metabolism ; Reproductive Medicine ; Review</subject><ispartof>Reproductive Sciences, 2012-07, Vol.19 (7), p.674-683</ispartof><rights>The Author(s) 2012</rights><rights>Society for Reproductive Investigation 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-b65a35fb42d572cfb5384e6ad13f73a8f5972aaade737979f6485c0b74dd450c3</citedby><cites>FETCH-LOGICAL-c409t-b65a35fb42d572cfb5384e6ad13f73a8f5972aaade737979f6485c0b74dd450c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1933719111430993$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1933719111430993$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>313,314,776,780,788,21800,27901,27903,27904,41467,42536,43600,43601,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26181095$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22534323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shang, Kewei</creatorcontrib><creatorcontrib>Jia, Xiao</creatorcontrib><creatorcontrib>Qiao, Jie</creatorcontrib><creatorcontrib>Kang, Jihong</creatorcontrib><creatorcontrib>Guan, Youfei</creatorcontrib><title>Endometrial Abnormality in Women With Polycystic Ovary Syndrome</title><title>Reproductive Sciences</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo- or anovulation combined with hyperandrogenism. With the higher rate of implantation failure after induction of ovulation or higher risk of spontaneous miscarriage after pregnancy, the reduced fertility is apparently attributed not only to anovulation but also to endometrial dysfunction in patients with PCOS. Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Embryology</subject><subject>Endometrial Neoplasms - etiology</subject><subject>Endometrial Neoplasms - prevention & control</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - metabolism</subject><subject>Endometrium - physiopathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Female - etiology</subject><subject>Infertility, Female - prevention & control</subject><subject>Medical sciences</subject><subject>Medicine & Public Health</subject><subject>Molecular Targeted Therapy</subject><subject>Non tumoral diseases</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Polycystic Ovary Syndrome - drug therapy</subject><subject>Polycystic Ovary Syndrome - metabolism</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><subject>Receptors, Steroid - agonists</subject><subject>Receptors, Steroid - antagonists & inhibitors</subject><subject>Receptors, Steroid - metabolism</subject><subject>Reproductive Medicine</subject><subject>Review</subject><issn>1933-7191</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtLAzEUhYMotlb3rmQ2gpvRPCeTlZRSH1CooOJyyORRp8yjJjPC_HtTOlVwIW6ScM937r05AJwjeI0Q5zdIEMKRQAhRAoUgB2C8LcUcQ3a4fwd9BE68X0PIqMDpMRhhzAglmIzB7bzWTWVaV8gymuZ14ypZFm0fFXX0FoRwFu179NSUvep9W6ho-SldHz33tXZBPwVHVpbenA33BLzezV9mD_Fief84my5iRaFo4zxhkjCbU6wZx8rmjKTUJFIjYjmRqWWCYymlNpxwwYVNaMoUzDnVmjKoyARc7fpuXPPRGd9mVeGVKUtZm6bzGYKYhD8hTgMKd6hyjffO2GzjiiosHaBsG1v2O7ZguRi6d3ll9Ldhn1MALgdAeiVL62StCv_DJShFULDAoR3ng1SvjMvWTefqkMxfw-PBI1fmH_wXMrmPgQ</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Shang, Kewei</creator><creator>Jia, Xiao</creator><creator>Qiao, Jie</creator><creator>Kang, Jihong</creator><creator>Guan, Youfei</creator><general>SAGE Publications</general><general>Springer International Publishing</general><general>Sage Publications</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Endometrial Abnormality in Women With Polycystic Ovary Syndrome</title><author>Shang, Kewei ; Jia, Xiao ; Qiao, Jie ; Kang, Jihong ; Guan, Youfei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-b65a35fb42d572cfb5384e6ad13f73a8f5972aaade737979f6485c0b74dd450c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Embryology</topic><topic>Endometrial Neoplasms - etiology</topic><topic>Endometrial Neoplasms - prevention & control</topic><topic>Endometrium - drug effects</topic><topic>Endometrium - metabolism</topic><topic>Endometrium - physiopathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Female - etiology</topic><topic>Infertility, Female - prevention & control</topic><topic>Medical sciences</topic><topic>Medicine & Public Health</topic><topic>Molecular Targeted Therapy</topic><topic>Non tumoral diseases</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Polycystic Ovary Syndrome - drug therapy</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Receptors, Steroid - agonists</topic><topic>Receptors, Steroid - antagonists & inhibitors</topic><topic>Receptors, Steroid - metabolism</topic><topic>Reproductive Medicine</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shang, Kewei</creatorcontrib><creatorcontrib>Jia, Xiao</creatorcontrib><creatorcontrib>Qiao, Jie</creatorcontrib><creatorcontrib>Kang, Jihong</creatorcontrib><creatorcontrib>Guan, Youfei</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shang, Kewei</au><au>Jia, Xiao</au><au>Qiao, Jie</au><au>Kang, Jihong</au><au>Guan, Youfei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endometrial Abnormality in Women With Polycystic Ovary Syndrome</atitle><jtitle>Reproductive Sciences</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>19</volume><issue>7</issue><spage>674</spage><epage>683</epage><pages>674-683</pages><issn>1933-7191</issn><eissn>1933-7205</eissn><abstract>Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo- or anovulation combined with hyperandrogenism. With the higher rate of implantation failure after induction of ovulation or higher risk of spontaneous miscarriage after pregnancy, the reduced fertility is apparently attributed not only to anovulation but also to endometrial dysfunction in patients with PCOS. Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22534323</pmid><doi>10.1177/1933719111430993</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Embryology Endometrial Neoplasms - etiology Endometrial Neoplasms - prevention & control Endometrium - drug effects Endometrium - metabolism Endometrium - physiopathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Infertility, Female - etiology Infertility, Female - prevention & control Medical sciences Medicine & Public Health Molecular Targeted Therapy Non tumoral diseases Obstetrics/Perinatology/Midwifery Polycystic Ovary Syndrome - drug therapy Polycystic Ovary Syndrome - metabolism Polycystic Ovary Syndrome - physiopathology Receptors, Steroid - agonists Receptors, Steroid - antagonists & inhibitors Receptors, Steroid - metabolism Reproductive Medicine Review |
| title | Endometrial Abnormality in Women With Polycystic Ovary Syndrome |
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