Diagnostic Value of FDG-PET/CT for Lymph Node Metastasis of Colorectal Cancer
Background Lymph node metastasis is an important prognostic factor in patients with colorectal cancer. We assessed the ability of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to diagnose lymph node metastases in colorectal cancer patients. Methods We retrospe...
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| Veröffentlicht in: | World journal of surgery 2012-08, Vol.36 (8), p.1898-1905 |
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| creator | Kwak, Jae Young Kim, Jae Seung Kim, Hye Jin Ha, Hyun Kwon Yu, Chang Sik Kim, Jin Cheon |
| description | Background
Lymph node metastasis is an important prognostic factor in patients with colorectal cancer. We assessed the ability of
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to diagnose lymph node metastases in colorectal cancer patients.
Methods
We retrospectively analyzed the records of 473 patients who underwent preoperative FDG-PET/CT, followed by curative surgery for colorectal cancer. Lymph node metastases were assessed as proximal or distal, depending on their anatomical location. We analyzed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG-PET/CT and CT for detecting lymph node metastases.
Results
In detecting proximal lymph nodes, FDG-PET/CT had a sensitivity of 66 %, a specificity of 60 %, a PPV of 63 %, an NPV of 62 %, and an accuracy of 63 %; whereas CT had a sensitivity of 87 %, a specificity of 29 %, a PPV of 57 %, an NPV of 68 %, and an accuracy of 59 % (
P
= 0.245). FDG-PET/CT and CT also showed similar accuracy in detecting distal lymph nodes (87 vs. 88 %,
P
= 0.620).
Conclusion
Preoperative FDG-PET/CT and CT have comparable accuracy in detecting lymph node metastases of colorectal cancer. |
| doi_str_mv | 10.1007/s00268-012-1575-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1023534136</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1023534136</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6284-6672f6bf9a0b1fdba99293cbb24ac6c9906a49a48772d56cdd70028ec65728563</originalsourceid><addsrcrecordid>eNqFkF1LwzAYhYMoOqc_wBspeONNNXnTps2lds4P5gc49TKkaaqVrpnJiuzfm9opIogQSC6eczh5ENoj-IhgnBw7jIGlISYQkjiJQ7qGBiSiEAIFuo4GmLLIvwndQtvOvWJMEobZJtoCiIFhCgN0Parkc2PcolLBo6xbHZgyGI_Ow7uz6XE2DUpjg8lyNn8Jbkyhg2u9kM6fynVcZmpjtVrIOshko7TdQRulrJ3eXd1D9DA-m2YX4eT2_DI7mYSKQRqFjCVQsrzkEuekLHLJOXCq8hwiqZjiHDMZcRmlSQJFzFRRJP6nqVYsTiCNGR2iw753bs1bq91CzCqndF3LRpvWCYKBxjQitEMPfqGvprWNX_dJEU4IUE-RnlLWOGd1Kea2mkm79JDoXIvetfCuRedadJn9VXObz3TxnfiS6wHeA-9VrZf_N4qnq_vTMY45j3wW-qzzseZZ25-z_1r0AXaklrc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1023191123</pqid></control><display><type>article</type><title>Diagnostic Value of FDG-PET/CT for Lymph Node Metastasis of Colorectal Cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SpringerLink Journals - AutoHoldings</source><creator>Kwak, Jae Young ; Kim, Jae Seung ; Kim, Hye Jin ; Ha, Hyun Kwon ; Yu, Chang Sik ; Kim, Jin Cheon</creator><creatorcontrib>Kwak, Jae Young ; Kim, Jae Seung ; Kim, Hye Jin ; Ha, Hyun Kwon ; Yu, Chang Sik ; Kim, Jin Cheon</creatorcontrib><description>Background
Lymph node metastasis is an important prognostic factor in patients with colorectal cancer. We assessed the ability of
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to diagnose lymph node metastases in colorectal cancer patients.
Methods
We retrospectively analyzed the records of 473 patients who underwent preoperative FDG-PET/CT, followed by curative surgery for colorectal cancer. Lymph node metastases were assessed as proximal or distal, depending on their anatomical location. We analyzed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG-PET/CT and CT for detecting lymph node metastases.
Results
In detecting proximal lymph nodes, FDG-PET/CT had a sensitivity of 66 %, a specificity of 60 %, a PPV of 63 %, an NPV of 62 %, and an accuracy of 63 %; whereas CT had a sensitivity of 87 %, a specificity of 29 %, a PPV of 57 %, an NPV of 68 %, and an accuracy of 59 % (
P
= 0.245). FDG-PET/CT and CT also showed similar accuracy in detecting distal lymph nodes (87 vs. 88 %,
P
= 0.620).
Conclusion
Preoperative FDG-PET/CT and CT have comparable accuracy in detecting lymph node metastases of colorectal cancer.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-012-1575-3</identifier><identifier>PMID: 22526032</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Cardiac Surgery ; Chi-Square Distribution ; Colorectal cancer ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Fluorodeoxyglucose F18 ; General Surgery ; Humans ; Image Interpretation, Computer-Assisted ; Lymph Node Metastasis ; Lymphatic Metastasis - diagnostic imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multimodal Imaging ; Negative Predictive Value ; Neoplasm Staging ; Positive Predictive Value ; Positron Emission Tomography ; Predictive Value of Tests ; Prognosis ; Radiopharmaceuticals ; Rectal Cancer ; Retrospective Studies ; Sensitivity and Specificity ; Surgery ; Thoracic Surgery ; Tomography, X-Ray Computed ; Vascular Surgery</subject><ispartof>World journal of surgery, 2012-08, Vol.36 (8), p.1898-1905</ispartof><rights>Société Internationale de Chirurgie 2012</rights><rights>2012 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6284-6672f6bf9a0b1fdba99293cbb24ac6c9906a49a48772d56cdd70028ec65728563</citedby><cites>FETCH-LOGICAL-c6284-6672f6bf9a0b1fdba99293cbb24ac6c9906a49a48772d56cdd70028ec65728563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-012-1575-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-012-1575-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,41471,42540,45557,45558,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22526032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwak, Jae Young</creatorcontrib><creatorcontrib>Kim, Jae Seung</creatorcontrib><creatorcontrib>Kim, Hye Jin</creatorcontrib><creatorcontrib>Ha, Hyun Kwon</creatorcontrib><creatorcontrib>Yu, Chang Sik</creatorcontrib><creatorcontrib>Kim, Jin Cheon</creatorcontrib><title>Diagnostic Value of FDG-PET/CT for Lymph Node Metastasis of Colorectal Cancer</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
Lymph node metastasis is an important prognostic factor in patients with colorectal cancer. We assessed the ability of
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to diagnose lymph node metastases in colorectal cancer patients.
Methods
We retrospectively analyzed the records of 473 patients who underwent preoperative FDG-PET/CT, followed by curative surgery for colorectal cancer. Lymph node metastases were assessed as proximal or distal, depending on their anatomical location. We analyzed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG-PET/CT and CT for detecting lymph node metastases.
Results
In detecting proximal lymph nodes, FDG-PET/CT had a sensitivity of 66 %, a specificity of 60 %, a PPV of 63 %, an NPV of 62 %, and an accuracy of 63 %; whereas CT had a sensitivity of 87 %, a specificity of 29 %, a PPV of 57 %, an NPV of 68 %, and an accuracy of 59 % (
P
= 0.245). FDG-PET/CT and CT also showed similar accuracy in detecting distal lymph nodes (87 vs. 88 %,
P
= 0.620).
Conclusion
Preoperative FDG-PET/CT and CT have comparable accuracy in detecting lymph node metastases of colorectal cancer.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiac Surgery</subject><subject>Chi-Square Distribution</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Lymph Node Metastasis</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Negative Predictive Value</subject><subject>Neoplasm Staging</subject><subject>Positive Predictive Value</subject><subject>Positron Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Radiopharmaceuticals</subject><subject>Rectal Cancer</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkF1LwzAYhYMoOqc_wBspeONNNXnTps2lds4P5gc49TKkaaqVrpnJiuzfm9opIogQSC6eczh5ENoj-IhgnBw7jIGlISYQkjiJQ7qGBiSiEAIFuo4GmLLIvwndQtvOvWJMEobZJtoCiIFhCgN0Parkc2PcolLBo6xbHZgyGI_Ow7uz6XE2DUpjg8lyNn8Jbkyhg2u9kM6fynVcZmpjtVrIOshko7TdQRulrJ3eXd1D9DA-m2YX4eT2_DI7mYSKQRqFjCVQsrzkEuekLHLJOXCq8hwiqZjiHDMZcRmlSQJFzFRRJP6nqVYsTiCNGR2iw753bs1bq91CzCqndF3LRpvWCYKBxjQitEMPfqGvprWNX_dJEU4IUE-RnlLWOGd1Kea2mkm79JDoXIvetfCuRedadJn9VXObz3TxnfiS6wHeA-9VrZf_N4qnq_vTMY45j3wW-qzzseZZ25-z_1r0AXaklrc</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Kwak, Jae Young</creator><creator>Kim, Jae Seung</creator><creator>Kim, Hye Jin</creator><creator>Ha, Hyun Kwon</creator><creator>Yu, Chang Sik</creator><creator>Kim, Jin Cheon</creator><general>Springer-Verlag</general><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Diagnostic Value of FDG-PET/CT for Lymph Node Metastasis of Colorectal Cancer</title><author>Kwak, Jae Young ; Kim, Jae Seung ; Kim, Hye Jin ; Ha, Hyun Kwon ; Yu, Chang Sik ; Kim, Jin Cheon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6284-6672f6bf9a0b1fdba99293cbb24ac6c9906a49a48772d56cdd70028ec65728563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiac Surgery</topic><topic>Chi-Square Distribution</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Lymph Node Metastasis</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Negative Predictive Value</topic><topic>Neoplasm Staging</topic><topic>Positive Predictive Value</topic><topic>Positron Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Radiopharmaceuticals</topic><topic>Rectal Cancer</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwak, Jae Young</creatorcontrib><creatorcontrib>Kim, Jae Seung</creatorcontrib><creatorcontrib>Kim, Hye Jin</creatorcontrib><creatorcontrib>Ha, Hyun Kwon</creatorcontrib><creatorcontrib>Yu, Chang Sik</creatorcontrib><creatorcontrib>Kim, Jin Cheon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwak, Jae Young</au><au>Kim, Jae Seung</au><au>Kim, Hye Jin</au><au>Ha, Hyun Kwon</au><au>Yu, Chang Sik</au><au>Kim, Jin Cheon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic Value of FDG-PET/CT for Lymph Node Metastasis of Colorectal Cancer</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2012-08</date><risdate>2012</risdate><volume>36</volume><issue>8</issue><spage>1898</spage><epage>1905</epage><pages>1898-1905</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
Lymph node metastasis is an important prognostic factor in patients with colorectal cancer. We assessed the ability of
18
F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to diagnose lymph node metastases in colorectal cancer patients.
Methods
We retrospectively analyzed the records of 473 patients who underwent preoperative FDG-PET/CT, followed by curative surgery for colorectal cancer. Lymph node metastases were assessed as proximal or distal, depending on their anatomical location. We analyzed the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of FDG-PET/CT and CT for detecting lymph node metastases.
Results
In detecting proximal lymph nodes, FDG-PET/CT had a sensitivity of 66 %, a specificity of 60 %, a PPV of 63 %, an NPV of 62 %, and an accuracy of 63 %; whereas CT had a sensitivity of 87 %, a specificity of 29 %, a PPV of 57 %, an NPV of 68 %, and an accuracy of 59 % (
P
= 0.245). FDG-PET/CT and CT also showed similar accuracy in detecting distal lymph nodes (87 vs. 88 %,
P
= 0.620).
Conclusion
Preoperative FDG-PET/CT and CT have comparable accuracy in detecting lymph node metastases of colorectal cancer.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22526032</pmid><doi>10.1007/s00268-012-1575-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Cardiac Surgery Chi-Square Distribution Colorectal cancer Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Fluorodeoxyglucose F18 General Surgery Humans Image Interpretation, Computer-Assisted Lymph Node Metastasis Lymphatic Metastasis - diagnostic imaging Male Medicine Medicine & Public Health Middle Aged Multimodal Imaging Negative Predictive Value Neoplasm Staging Positive Predictive Value Positron Emission Tomography Predictive Value of Tests Prognosis Radiopharmaceuticals Rectal Cancer Retrospective Studies Sensitivity and Specificity Surgery Thoracic Surgery Tomography, X-Ray Computed Vascular Surgery |
| title | Diagnostic Value of FDG-PET/CT for Lymph Node Metastasis of Colorectal Cancer |
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