Enhancement of Cisplatin Cytotoxicity by Disulfiram Involves Activating Transcription Factor 3

Activating transcription factor 3 (ATF3), a stress-inducible gene, is a regulator of cisplatin-induced cytotoxicity, and enhancement of the ATF3 expression potentiates this cytotoxicity. ATF3 expression and its binding to the transcription target CHOP were evaluated by western blot and chromatin imm...

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Veröffentlicht in:	Anticancer research 2012-07, Vol.32 (7), p.2679-2688
Hauptverfasser:	O'BRIEN, Anna, BARBER, Janet E. B, REID, Stephanie, NIKNEJAD, Nima, DIMITROULAKOS, Jim
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - biosynthesis Activating Transcription Factor 3 - genetics Adenocarcinoma - drug therapy Antineoplastic Combined Chemotherapy Protocols - pharmacology Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Cell Line Cell Line, Tumor Cisplatin - administration & dosage Cisplatin - pharmacology Disulfiram - administration & dosage Disulfiram - pharmacology Drug Synergism Female Gene Expression Regulation, Neoplastic - drug effects Humans Lung Neoplasms - drug therapy Male Medical sciences Ovarian Neoplasms - drug therapy Prostatic Neoplasms - drug therapy Transcription Factor CHOP - biosynthesis Transcription Factor CHOP - genetics Transcription, Genetic Tumors Up-Regulation - drug effects
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