Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer
Objectives To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer. Methods Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusio...
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| Veröffentlicht in: | European radiology 2012-08, Vol.22 (8), p.1693-1700 |
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| creator | Lim, Joon Seok Kim, Daehong Baek, Song-Ee Myoung, Sungmin Choi, Junjeong Shin, Sang Joon Kim, Myeong-Jin Kim, Nam Kyu Suh, Jinsuk Kim, Ki Whang Keum, Ki Chang |
| description | Objectives
To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer.
Methods
Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The
K
trans
(volume transfer constant) and
V
e
(extracellular extravascular space fraction) were calculated.
Results
Before CRT, the mean tumour
K
trans
in the downstaged group was significantly higher than that in the non-downstaged group (
P
= 0.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (
P
= 0.1392). Repeated-measures analysis of variance (ANOVA) showed significant differences for evolution of
K
trans
values both between downstaged and non-downstaged groups (
P
= 0.0215) and between TRG responders and TRG non-responders (
P
= 0.0001). Regarding
V
e
, no significant differences were observed both between downstaged and non-downstaged groups (
P
= 0.689) or between TRG responders and TRG non-responders (
P
= 0.887).
Conclusion
Perfusion MRI of rectal cancer can be useful for assessing tumoural
K
trans
changes by CRT. Tumours with high pre-CRT
K
trans
values tended to respond favourably to CRT, particularly in terms of downstaging criteria.
Key Points
•
Perfusion MRI can now assess therapeutic response of tumours to therapy
.
•
Tumours with high initial
K
trans
values responded favourably to chemoradiotherapy
.
•
Perfusion MRI of rectal cancer may help with decisions about management
. |
| doi_str_mv | 10.1007/s00330-012-2416-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1023298957</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1023298957</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-7ab60b1fd07bf054858c53430be6c384e50aefb772856496411a4facebeb72ad3</originalsourceid><addsrcrecordid>eNp1kU2L1TAUQIMoznP0B7iRgBs31ZuPNulShlEHRhTRdUnTG6dD29SbdOAt_O-mvFFEcBWSnHsSOIw9F_BaAJg3CUApqEDISmrRVOoBOwitZCXA6ofsAK2ylWlbfcaepHQLAK3Q5jE7k1JLI6w-sJ-fkcKWxrjwj1-ueIjE8w3ylXAYfd6PY-CZ0OUZl8wJ0xqXhNyFjLRjcUVyebxD7m9wjuSGMRYDufXIx4VP0btpOnI33LnF41AMPruJ-31HT9mj4KaEz-7Xc_bt3eXXiw_V9af3Vxdvryuvlc2VcX0DvQgDmD5ArW1tfa20gh4br6zGGhyG3hhp60a3jRbC6eA89tgb6QZ1zl6dvCvFHxum3M1j8jhNbsG4pU6AVLK1bW0K-vIf9DZutJTf7ZRsjKgNFEqcKE8xJcLQrTTOjo4F6vY23alNV9p0e5tOlZkX9-atn3H4M_E7RgHkCUjlavmO9PfT_7P-AmJYm1k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1022671570</pqid></control><display><type>article</type><title>Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Lim, Joon Seok ; Kim, Daehong ; Baek, Song-Ee ; Myoung, Sungmin ; Choi, Junjeong ; Shin, Sang Joon ; Kim, Myeong-Jin ; Kim, Nam Kyu ; Suh, Jinsuk ; Kim, Ki Whang ; Keum, Ki Chang</creator><creatorcontrib>Lim, Joon Seok ; Kim, Daehong ; Baek, Song-Ee ; Myoung, Sungmin ; Choi, Junjeong ; Shin, Sang Joon ; Kim, Myeong-Jin ; Kim, Nam Kyu ; Suh, Jinsuk ; Kim, Ki Whang ; Keum, Ki Chang</creatorcontrib><description>Objectives
To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer.
Methods
Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The
K
trans
(volume transfer constant) and
V
e
(extracellular extravascular space fraction) were calculated.
Results
Before CRT, the mean tumour
K
trans
in the downstaged group was significantly higher than that in the non-downstaged group (
P
= 0.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (
P
= 0.1392). Repeated-measures analysis of variance (ANOVA) showed significant differences for evolution of
K
trans
values both between downstaged and non-downstaged groups (
P
= 0.0215) and between TRG responders and TRG non-responders (
P
= 0.0001). Regarding
V
e
, no significant differences were observed both between downstaged and non-downstaged groups (
P
= 0.689) or between TRG responders and TRG non-responders (
P
= 0.887).
Conclusion
Perfusion MRI of rectal cancer can be useful for assessing tumoural
K
trans
changes by CRT. Tumours with high pre-CRT
K
trans
values tended to respond favourably to CRT, particularly in terms of downstaging criteria.
Key Points
•
Perfusion MRI can now assess therapeutic response of tumours to therapy
.
•
Tumours with high initial
K
trans
values responded favourably to chemoradiotherapy
.
•
Perfusion MRI of rectal cancer may help with decisions about management
.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-012-2416-3</identifier><identifier>PMID: 22427184</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Biomarkers ; Biomarkers - metabolism ; Cancer therapies ; Carcinoma - pathology ; Carcinoma - therapy ; Chemoradiotherapy - methods ; Colorectal cancer ; Combined Modality Therapy - methods ; Contrast Media - pharmacology ; Diagnostic Radiology ; Female ; Gastrointestinal ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance Angiography - methods ; Magnetic resonance imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Patients ; Perfusion ; Permeability ; Pharmacokinetics ; Prospective Studies ; Radiation therapy ; Radiology ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Surgery ; Treatment Outcome ; Tumors ; Ultrasound ; Variance analysis</subject><ispartof>European radiology, 2012-08, Vol.22 (8), p.1693-1700</ispartof><rights>European Society of Radiology 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-7ab60b1fd07bf054858c53430be6c384e50aefb772856496411a4facebeb72ad3</citedby><cites>FETCH-LOGICAL-c438t-7ab60b1fd07bf054858c53430be6c384e50aefb772856496411a4facebeb72ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-012-2416-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-012-2416-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22427184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Joon Seok</creatorcontrib><creatorcontrib>Kim, Daehong</creatorcontrib><creatorcontrib>Baek, Song-Ee</creatorcontrib><creatorcontrib>Myoung, Sungmin</creatorcontrib><creatorcontrib>Choi, Junjeong</creatorcontrib><creatorcontrib>Shin, Sang Joon</creatorcontrib><creatorcontrib>Kim, Myeong-Jin</creatorcontrib><creatorcontrib>Kim, Nam Kyu</creatorcontrib><creatorcontrib>Suh, Jinsuk</creatorcontrib><creatorcontrib>Kim, Ki Whang</creatorcontrib><creatorcontrib>Keum, Ki Chang</creatorcontrib><title>Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer.
Methods
Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The
K
trans
(volume transfer constant) and
V
e
(extracellular extravascular space fraction) were calculated.
Results
Before CRT, the mean tumour
K
trans
in the downstaged group was significantly higher than that in the non-downstaged group (
P
= 0.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (
P
= 0.1392). Repeated-measures analysis of variance (ANOVA) showed significant differences for evolution of
K
trans
values both between downstaged and non-downstaged groups (
P
= 0.0215) and between TRG responders and TRG non-responders (
P
= 0.0001). Regarding
V
e
, no significant differences were observed both between downstaged and non-downstaged groups (
P
= 0.689) or between TRG responders and TRG non-responders (
P
= 0.887).
Conclusion
Perfusion MRI of rectal cancer can be useful for assessing tumoural
K
trans
changes by CRT. Tumours with high pre-CRT
K
trans
values tended to respond favourably to CRT, particularly in terms of downstaging criteria.
Key Points
•
Perfusion MRI can now assess therapeutic response of tumours to therapy
.
•
Tumours with high initial
K
trans
values responded favourably to chemoradiotherapy
.
•
Perfusion MRI of rectal cancer may help with decisions about management
.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Cancer therapies</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - therapy</subject><subject>Chemoradiotherapy - methods</subject><subject>Colorectal cancer</subject><subject>Combined Modality Therapy - methods</subject><subject>Contrast Media - pharmacology</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Gastrointestinal</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Permeability</subject><subject>Pharmacokinetics</subject><subject>Prospective Studies</subject><subject>Radiation therapy</subject><subject>Radiology</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Ultrasound</subject><subject>Variance analysis</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU2L1TAUQIMoznP0B7iRgBs31ZuPNulShlEHRhTRdUnTG6dD29SbdOAt_O-mvFFEcBWSnHsSOIw9F_BaAJg3CUApqEDISmrRVOoBOwitZCXA6ofsAK2ylWlbfcaepHQLAK3Q5jE7k1JLI6w-sJ-fkcKWxrjwj1-ueIjE8w3ylXAYfd6PY-CZ0OUZl8wJ0xqXhNyFjLRjcUVyebxD7m9wjuSGMRYDufXIx4VP0btpOnI33LnF41AMPruJ-31HT9mj4KaEz-7Xc_bt3eXXiw_V9af3Vxdvryuvlc2VcX0DvQgDmD5ArW1tfa20gh4br6zGGhyG3hhp60a3jRbC6eA89tgb6QZ1zl6dvCvFHxum3M1j8jhNbsG4pU6AVLK1bW0K-vIf9DZutJTf7ZRsjKgNFEqcKE8xJcLQrTTOjo4F6vY23alNV9p0e5tOlZkX9-atn3H4M_E7RgHkCUjlavmO9PfT_7P-AmJYm1k</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Lim, Joon Seok</creator><creator>Kim, Daehong</creator><creator>Baek, Song-Ee</creator><creator>Myoung, Sungmin</creator><creator>Choi, Junjeong</creator><creator>Shin, Sang Joon</creator><creator>Kim, Myeong-Jin</creator><creator>Kim, Nam Kyu</creator><creator>Suh, Jinsuk</creator><creator>Kim, Ki Whang</creator><creator>Keum, Ki Chang</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer</title><author>Lim, Joon Seok ; Kim, Daehong ; Baek, Song-Ee ; Myoung, Sungmin ; Choi, Junjeong ; Shin, Sang Joon ; Kim, Myeong-Jin ; Kim, Nam Kyu ; Suh, Jinsuk ; Kim, Ki Whang ; Keum, Ki Chang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-7ab60b1fd07bf054858c53430be6c384e50aefb772856496411a4facebeb72ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Cancer therapies</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - therapy</topic><topic>Chemoradiotherapy - methods</topic><topic>Colorectal cancer</topic><topic>Combined Modality Therapy - methods</topic><topic>Contrast Media - pharmacology</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Gastrointestinal</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Patients</topic><topic>Perfusion</topic><topic>Permeability</topic><topic>Pharmacokinetics</topic><topic>Prospective Studies</topic><topic>Radiation therapy</topic><topic>Radiology</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Ultrasound</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Joon Seok</creatorcontrib><creatorcontrib>Kim, Daehong</creatorcontrib><creatorcontrib>Baek, Song-Ee</creatorcontrib><creatorcontrib>Myoung, Sungmin</creatorcontrib><creatorcontrib>Choi, Junjeong</creatorcontrib><creatorcontrib>Shin, Sang Joon</creatorcontrib><creatorcontrib>Kim, Myeong-Jin</creatorcontrib><creatorcontrib>Kim, Nam Kyu</creatorcontrib><creatorcontrib>Suh, Jinsuk</creatorcontrib><creatorcontrib>Kim, Ki Whang</creatorcontrib><creatorcontrib>Keum, Ki Chang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Joon Seok</au><au>Kim, Daehong</au><au>Baek, Song-Ee</au><au>Myoung, Sungmin</au><au>Choi, Junjeong</au><au>Shin, Sang Joon</au><au>Kim, Myeong-Jin</au><au>Kim, Nam Kyu</au><au>Suh, Jinsuk</au><au>Kim, Ki Whang</au><au>Keum, Ki Chang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>22</volume><issue>8</issue><spage>1693</spage><epage>1700</epage><pages>1693-1700</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
To evaluate the utility of perfusion MRI as a potential biomarker for predicting response to chemoradiotherapy (CRT) in locally advanced rectal cancer.
Methods
Thirty-nine patients with primary rectal carcinoma who were scheduled for preoperative CRT were prospectively recruited. Perfusion MRI was performed with a 3.0-T MRI system in all patients before therapy, at the end of the 2nd week of therapy, and before surgery. The
K
trans
(volume transfer constant) and
V
e
(extracellular extravascular space fraction) were calculated.
Results
Before CRT, the mean tumour
K
trans
in the downstaged group was significantly higher than that in the non-downstaged group (
P
= 0.0178), but there was no significant difference between tumour regression grade (TRG) responders and TRG non-responders (
P
= 0.1392). Repeated-measures analysis of variance (ANOVA) showed significant differences for evolution of
K
trans
values both between downstaged and non-downstaged groups (
P
= 0.0215) and between TRG responders and TRG non-responders (
P
= 0.0001). Regarding
V
e
, no significant differences were observed both between downstaged and non-downstaged groups (
P
= 0.689) or between TRG responders and TRG non-responders (
P
= 0.887).
Conclusion
Perfusion MRI of rectal cancer can be useful for assessing tumoural
K
trans
changes by CRT. Tumours with high pre-CRT
K
trans
values tended to respond favourably to CRT, particularly in terms of downstaging criteria.
Key Points
•
Perfusion MRI can now assess therapeutic response of tumours to therapy
.
•
Tumours with high initial
K
trans
values responded favourably to chemoradiotherapy
.
•
Perfusion MRI of rectal cancer may help with decisions about management
.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22427184</pmid><doi>10.1007/s00330-012-2416-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2012-08, Vol.22 (8), p.1693-1700 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1023298957 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Biomarkers Biomarkers - metabolism Cancer therapies Carcinoma - pathology Carcinoma - therapy Chemoradiotherapy - methods Colorectal cancer Combined Modality Therapy - methods Contrast Media - pharmacology Diagnostic Radiology Female Gastrointestinal Humans Imaging Internal Medicine Interventional Radiology Magnetic Resonance Angiography - methods Magnetic resonance imaging Male Medicine Medicine & Public Health Middle Aged Neuroradiology Patients Perfusion Permeability Pharmacokinetics Prospective Studies Radiation therapy Radiology Rectal Neoplasms - pathology Rectal Neoplasms - therapy Surgery Treatment Outcome Tumors Ultrasound Variance analysis |
| title | Perfusion MRI for the prediction of treatment response after preoperative chemoradiotherapy in locally advanced rectal cancer |
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