The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation

Background The COMT enzyme metabolizes catecholamines and thus modulates adrenergic, noradrenergic and dopaminergic signaling. A functional polymorphism in the gene encoding this enzyme, i.e. the COMT Val158Met SNP that reduces enzyme activity, has previously been linked to pain sensitivity. Methods...

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Veröffentlicht in:	European journal of pain 2012-08, Vol.16 (7), p.1064-1069
Hauptverfasser:	Jacobsen, L.M., Schistad, E.I., Storesund, A., Pedersen, L.M., Rygh, L.J., Røe, C., Gjerstad, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Catechol O-Methyltransferase - genetics Disability Evaluation Diskectomy Female Gene Frequency Genotype Humans Intervertebral Disc Displacement - complications Intervertebral Disc Displacement - genetics Intervertebral Disc Displacement - surgery Low Back Pain - etiology Low Back Pain - genetics Low Back Pain - surgery Lumbar Vertebrae - surgery Male Middle Aged Pain Measurement Polymorphism, Single Nucleotide Sciatica - etiology Sciatica - genetics Sciatica - surgery Treatment Outcome
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