Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth

Chlamydia pneumoniae is a worldwide cause of various respiratory track diseases ranging from asymptomatic pharyngeal infection to severe, sometimes fatal pneumonia. We have previously identified 2-arylbenzimidazoles as highly active antichlamydial compounds. In this work the importance of conformati...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-07, Vol.22 (14), p.4882-4886
Hauptverfasser:	Siiskonen, Antti, Keurulainen, Leena, Salin, Olli, Kiuru, Paula, Pohjala, Leena, Vuorela, Pia, Yli-Kauhaluoma, Jari
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arylbenzimidazoles Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Benzimidazoles - chemistry Benzimidazoles - pharmacology Biological and medical sciences Chlamydia pneumoniae Chlamydophila pneumoniae Chlamydophila pneumoniae - drug effects Chlamydophila pneumoniae - growth & development Conformational effects energy heterocyclic compounds Medical sciences Microbial Viability - drug effects Models, Molecular Molecular Conformation N-Phenylbenzamides pharmacology Pharmacology. Drug treatments pneumonia Structure-Activity Relationship structure-activity relationships
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