Statin therapy prevents expansive remodeling in venous bypass grafts

Abstract Background Venous grafts (VG) have high failure rates by 10 years in aortocoronary bypass surgery. We have previously shown that expansive remodeling followed by increased LDL retention are early atherosclerotic changes in experimental VG placed in the arterial circulation. The objective of...

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Veröffentlicht in:	Atherosclerosis 2012-07, Vol.223 (1), p.106-113
Hauptverfasser:	Qiang, Beiping, Toma, Jonathan, Fujii, Hiroko, Osherov, Azriel B, Nili, Nafiseh, Sparkes, John D, Fefer, Paul, Samuel, Michelle, Butany, Jagdish, Leong-Poi, Howard, Strauss, Bradley H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anastomosis, Surgical Animals atherosclerosis Atherosclerosis (general aspects, experimental research) Atorvastatin Calcium Biological and medical sciences Biomarkers - blood Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cardiovascular carotid arteries Carotid Artery, Common - surgery Cell Proliferation - drug effects cholesterol Cholesterol, Dietary - administration & dosage Cholesterol, Dietary - blood Expansive positive remodeling Heptanoic Acids - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hyperplasia Immunohistochemistry Intimal hyperplasia Jugular Veins - diagnostic imaging Jugular Veins - drug effects Jugular Veins - metabolism Jugular Veins - pathology Jugular Veins - transplantation low density lipoprotein macrophages Macrophages - drug effects Macrophages - metabolism Matrix metalloproteinase Matrix Metalloproteinase 12 - metabolism Matrix Metalloproteinase 2 - metabolism Medical sciences Models, Animal Neointima Pharmacology. Drug treatments proteolysis Pyrroles - pharmacology Rabbits Saphenous vein grafts surgery Time Factors ultrasonics Ultrasonography Vascular Grafting - adverse effects
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