Hypoxia response in asthma: differential modulation on inflammation and epithelial injury

Oxygen-sensing prolyl-hydroxylase (PHD)-2 negatively regulates hypoxia-inducible factor (HIF)1-α and suppresses the hypoxic response. Hypoxia signaling is thought to be proinflammatory but also attenuates cellular injury and apoptosis. Although increased hypoxic response has been noted in asthma, it...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2012-07, Vol.47 (1), p.1-10
Hauptverfasser:	Ahmad, Tanveer, Kumar, Manish, Mabalirajan, Ulaganathan, Pattnaik, Bijay, Aggarwal, Shilpi, Singh, Ranjana, Singh, Suchita, Mukerji, Mitali, Ghosh, Balaram, Agrawal, Anurag
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Remodeling Animals Apoptosis Asthma - chemically induced Asthma - immunology Asthma - pathology Cell Hypoxia CX3C Chemokine Receptor 1 Hydroxybenzoates - pharmacology Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Inflammation - immunology Lung - immunology Lung - pathology Male Methacholine Chloride - pharmacology Mice Mice, Inbred BALB C Mice, Inbred C57BL Procollagen-Proline Dioxygenase - metabolism Receptors, Chemokine - biosynthesis Respiratory Mucosa - immunology Respiratory Mucosa - pathology RNA Interference RNA, Small Interfering Signal Transduction
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