Radiological features of Gorham’s disease
Aim To describe the key findings on plain radiography, computed tomography (CT), and magnetic resonance imaging (MRI) of Gorham’s disease. Materials and methods Eight children diagnosed with Gorham’s disease between 1999 and 2009 were included. All imaging studies performed on each patient were revi...
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| Veröffentlicht in: | Clinical radiology 2012-08, Vol.67 (8), p.782-788 |
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| creator | Kotecha, R Mascarenhas, L Jackson, H.A Venkatramani, R |
| description | Aim To describe the key findings on plain radiography, computed tomography (CT), and magnetic resonance imaging (MRI) of Gorham’s disease. Materials and methods Eight children diagnosed with Gorham’s disease between 1999 and 2009 were included. All imaging studies performed on each patient were reviewed with special attention to the extent of bone, soft tissue, and visceral involvement. Results All patients had bone lesions at diagnosis, most commonly in the vertebrae. CT showed generalized osteopenia, multiple lytic lesions, and heterogeneous bone density. MRI demonstrated altered signal intensity in bone marrow that was hyperintense on T1 imaging. Seven patients had soft-tissue lymphangiomatous lesions adjacent to identified osseous lesions. Four patients had chylous pleural effusions: three with bilateral and one with unilateral involvement. The spleen was involved in six patients. Conclusion Splenic lesions and soft-tissue involvement are common in patients with Gorham’s disease. The presence of extra-osseous lesions along with characteristic bone lesions on plain radiography may be pathognomonic of Gorham’s disease. |
| doi_str_mv | 10.1016/j.crad.2012.01.009 |
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Materials and methods Eight children diagnosed with Gorham’s disease between 1999 and 2009 were included. All imaging studies performed on each patient were reviewed with special attention to the extent of bone, soft tissue, and visceral involvement. Results All patients had bone lesions at diagnosis, most commonly in the vertebrae. CT showed generalized osteopenia, multiple lytic lesions, and heterogeneous bone density. MRI demonstrated altered signal intensity in bone marrow that was hyperintense on T1 imaging. Seven patients had soft-tissue lymphangiomatous lesions adjacent to identified osseous lesions. Four patients had chylous pleural effusions: three with bilateral and one with unilateral involvement. The spleen was involved in six patients. Conclusion Splenic lesions and soft-tissue involvement are common in patients with Gorham’s disease. The presence of extra-osseous lesions along with characteristic bone lesions on plain radiography may be pathognomonic of Gorham’s disease.</description><identifier>ISSN: 0009-9260</identifier><identifier>EISSN: 1365-229X</identifier><identifier>DOI: 10.1016/j.crad.2012.01.009</identifier><identifier>PMID: 22424931</identifier><identifier>CODEN: CLRAAG</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adolescent ; Biological and medical sciences ; Child ; Diseases of the osteoarticular system ; Female ; Follow-Up Studies ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Lung Diseases - complications ; Lung Diseases - diagnosis ; Lung Diseases - diagnostic imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Miscellaneous. Osteoarticular involvement in other diseases ; Osteolysis, Essential - complications ; Osteolysis, Essential - diagnosis ; Osteolysis, Essential - diagnostic imaging ; Pleural Effusion - complications ; Pleural Effusion - diagnosis ; Pleural Effusion - diagnostic imaging ; Radiology ; Radionuclide Imaging ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Splenic Diseases - complications ; Splenic Diseases - diagnosis ; Splenic Diseases - diagnostic imaging ; Tomography, X-Ray Computed - methods</subject><ispartof>Clinical radiology, 2012-08, Vol.67 (8), p.782-788</ispartof><rights>The Royal College of Radiologists</rights><rights>2012 The Royal College of Radiologists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-b79f7ce0f68ce3d1456bc7e8be71aa1a0c86147afe9996a816ec9a0fb953254b3</citedby><cites>FETCH-LOGICAL-c441t-b79f7ce0f68ce3d1456bc7e8be71aa1a0c86147afe9996a816ec9a0fb953254b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009926012000670$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26127743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22424931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kotecha, R</creatorcontrib><creatorcontrib>Mascarenhas, L</creatorcontrib><creatorcontrib>Jackson, H.A</creatorcontrib><creatorcontrib>Venkatramani, R</creatorcontrib><title>Radiological features of Gorham’s disease</title><title>Clinical radiology</title><addtitle>Clin Radiol</addtitle><description>Aim To describe the key findings on plain radiography, computed tomography (CT), and magnetic resonance imaging (MRI) of Gorham’s disease. Materials and methods Eight children diagnosed with Gorham’s disease between 1999 and 2009 were included. All imaging studies performed on each patient were reviewed with special attention to the extent of bone, soft tissue, and visceral involvement. Results All patients had bone lesions at diagnosis, most commonly in the vertebrae. CT showed generalized osteopenia, multiple lytic lesions, and heterogeneous bone density. MRI demonstrated altered signal intensity in bone marrow that was hyperintense on T1 imaging. Seven patients had soft-tissue lymphangiomatous lesions adjacent to identified osseous lesions. Four patients had chylous pleural effusions: three with bilateral and one with unilateral involvement. The spleen was involved in six patients. Conclusion Splenic lesions and soft-tissue involvement are common in patients with Gorham’s disease. The presence of extra-osseous lesions along with characteristic bone lesions on plain radiography may be pathognomonic of Gorham’s disease.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lung Diseases - complications</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - diagnostic imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Osteolysis, Essential - complications</subject><subject>Osteolysis, Essential - diagnosis</subject><subject>Osteolysis, Essential - diagnostic imaging</subject><subject>Pleural Effusion - complications</subject><subject>Pleural Effusion - diagnosis</subject><subject>Pleural Effusion - diagnostic imaging</subject><subject>Radiology</subject><subject>Radionuclide Imaging</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Splenic Diseases - complications</subject><subject>Splenic Diseases - diagnosis</subject><subject>Splenic Diseases - diagnostic imaging</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>0009-9260</issn><issn>1365-229X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd9qFDEUh0NR2m3tC_Si7I0glJnmZGYyGxBBilahIPgHvAtnMieadXZSc3aE3vkavl6fxAy7VvDCq5OE73cI30-IM5AlSNCX69Il7EslQZUSSinNgVhApZtCKfP5kVjI_FQYpeWROGZez9da1YfiSKk8TQULcfEe-xCH-CU4HJaecDsl4mX0y-uYvuLm_ucvXvaBCZmeiMceB6bT_TwRn16_-nj1prh5d_326uVN4eoatkXXGt86kl6vHFU91I3uXEurjlpABJRupaFu0ZMxRuMKNDmD0nemqVRTd9WJeLbbe5vi94l4azeBHQ0DjhQntiBVpYzWTZNRtUNdisyJvL1NYYPpLkN2lmTXdpZkZ0lWgs0Kcuh8v3_qNtQ_RP5YycDTPYCctfiEowv8l9Og2rauMvd8x1G28SNQsuwCjY76kMhtbR_D___x4p-4G8I4F_GN7ojXcUpj9mzBcs7YD3N_c5ug8km3svoN-Q-Zew</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Kotecha, R</creator><creator>Mascarenhas, L</creator><creator>Jackson, H.A</creator><creator>Venkatramani, R</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>Radiological features of Gorham’s disease</title><author>Kotecha, R ; Mascarenhas, L ; Jackson, H.A ; Venkatramani, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-b79f7ce0f68ce3d1456bc7e8be71aa1a0c86147afe9996a816ec9a0fb953254b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lung Diseases - complications</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - diagnostic imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Osteolysis, Essential - complications</topic><topic>Osteolysis, Essential - diagnosis</topic><topic>Osteolysis, Essential - diagnostic imaging</topic><topic>Pleural Effusion - complications</topic><topic>Pleural Effusion - diagnosis</topic><topic>Pleural Effusion - diagnostic imaging</topic><topic>Radiology</topic><topic>Radionuclide Imaging</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Splenic Diseases - complications</topic><topic>Splenic Diseases - diagnosis</topic><topic>Splenic Diseases - diagnostic imaging</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kotecha, R</creatorcontrib><creatorcontrib>Mascarenhas, L</creatorcontrib><creatorcontrib>Jackson, H.A</creatorcontrib><creatorcontrib>Venkatramani, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kotecha, R</au><au>Mascarenhas, L</au><au>Jackson, H.A</au><au>Venkatramani, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiological features of Gorham’s disease</atitle><jtitle>Clinical radiology</jtitle><addtitle>Clin Radiol</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>67</volume><issue>8</issue><spage>782</spage><epage>788</epage><pages>782-788</pages><issn>0009-9260</issn><eissn>1365-229X</eissn><coden>CLRAAG</coden><abstract>Aim To describe the key findings on plain radiography, computed tomography (CT), and magnetic resonance imaging (MRI) of Gorham’s disease. Materials and methods Eight children diagnosed with Gorham’s disease between 1999 and 2009 were included. All imaging studies performed on each patient were reviewed with special attention to the extent of bone, soft tissue, and visceral involvement. Results All patients had bone lesions at diagnosis, most commonly in the vertebrae. CT showed generalized osteopenia, multiple lytic lesions, and heterogeneous bone density. MRI demonstrated altered signal intensity in bone marrow that was hyperintense on T1 imaging. Seven patients had soft-tissue lymphangiomatous lesions adjacent to identified osseous lesions. Four patients had chylous pleural effusions: three with bilateral and one with unilateral involvement. The spleen was involved in six patients. Conclusion Splenic lesions and soft-tissue involvement are common in patients with Gorham’s disease. The presence of extra-osseous lesions along with characteristic bone lesions on plain radiography may be pathognomonic of Gorham’s disease.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>22424931</pmid><doi>10.1016/j.crad.2012.01.009</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Child Diseases of the osteoarticular system Female Follow-Up Studies Humans Investigative techniques, diagnostic techniques (general aspects) Lung Diseases - complications Lung Diseases - diagnosis Lung Diseases - diagnostic imaging Magnetic Resonance Imaging - methods Male Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Osteolysis, Essential - complications Osteolysis, Essential - diagnosis Osteolysis, Essential - diagnostic imaging Pleural Effusion - complications Pleural Effusion - diagnosis Pleural Effusion - diagnostic imaging Radiology Radionuclide Imaging Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Splenic Diseases - complications Splenic Diseases - diagnosis Splenic Diseases - diagnostic imaging Tomography, X-Ray Computed - methods |
| title | Radiological features of Gorham’s disease |
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