Toward tailored medicine (and beyond): the phaeochromocytoma and paraganglioma model
Using the PCC (phaeochromocytomas)/PGL (paragangliomas) as the model, Cuccurullo and Mansi discuss whether new better performing radio-compounds necessarily determine the disappearance of the older ones. 123I MIBG remains the first choice when the presence of a PCC or a PGL is suspected. 68Ga-DOTA p...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2012-08, Vol.39 (8), p.1262-1265 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | Cuccurullo, Vincenzo Mansi, Luigi |
| description | Using the PCC (phaeochromocytomas)/PGL (paragangliomas) as the model, Cuccurullo and Mansi discuss whether new better performing radio-compounds necessarily determine the disappearance of the older ones. 123I MIBG remains the first choice when the presence of a PCC or a PGL is suspected. 68Ga-DOTA peptides should be considered: (a) as the first-line investigation in patients at high risk of PGL and metastatic disease, for example for screening carriers for mutations associated with familial PGL syndromes; (b) as the next investigation if 123I-MIBG does not detect lesions in patients with a high pretest probability of PCC or PGL; and (c) in preference to 123I-MIBG if metastatic spread, particularly to the bone, is suspected. |
| doi_str_mv | 10.1007/s00259-012-2156-2 |
| format | Article |
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| subjects | 3-Iodobenzylguanidine Adrenal Gland Neoplasms - diagnostic imaging Cancer Cardiology Editorial Commentary Endocrinology Humans Imaging Medicine Medicine & Public Health Multimodal Imaging - methods Nuclear Medicine Oncology Organometallic Compounds Orthopedics Paraganglioma - diagnostic imaging Pheochromocytoma - diagnostic imaging Positron-Emission Tomography Radiology Tomography Tomography, Emission-Computed, Single-Photon - methods Tomography, X-Ray Computed Tumors |
| title | Toward tailored medicine (and beyond): the phaeochromocytoma and paraganglioma model |
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