Dual testing with QF-PCR and karyotype analysis for prenatal diagnosis of chromosomal abnormalities. Evaluation of 13 500 cases with consideration of using QF-PCR as a stand-alone test according to referral indications

ABSTRACT Objective Evaluate the results obtained from Quantitative Fluorescent (QF)‐PCR and conventional karyotype analysis to determine the advantages and disadvantages of dual testing in prenatal diagnosis. Methods From 1 June 2006 to 1 June 2010, dual testing by QF‐PCR and karyotype analysis was...

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Veröffentlicht in:	Prenatal diagnosis 2012-07, Vol.32 (7), p.680-685
Hauptverfasser:	Papoulidis, Ioannis, Siomou, Elisavet, Sotiriadis, Alexandros, Efstathiou, George, Psara, Anastasia, Sevastopoulou, Eirini, Anastasakis, Eleftherios, Sifakis, Stavros, Tsiligianni, Theodora, Kontodiou, Maria, Malamaki, Christine, Tzimina, Maria, Petersen, Michael Bjorn, Manolakos, Emmanouil, Athanasiadis, Apostolos
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniocentesis Chorionic Villi Sampling Chromosome Aberrations Chromosome Disorders - diagnosis Chromosome Disorders - genetics Female Humans Karyotyping - methods Microsatellite Repeats Polymerase Chain Reaction - methods Pregnancy Prenatal Diagnosis - methods Sensitivity and Specificity
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