Redox Mechanisms of Nodularin and Chemically Degraded Nodularin

The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Electroanalysis (New York, N.Y.) N.Y.), 2011-10, Vol.23 (10), p.2310-2319
Hauptverfasser: Santos, Paulina V. F., Lopes , Ilanna C., Diculescu, Victor C., de Araújo, Mário César U., Oliveira-Brett, Ana Maria
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 2319
container_issue 10
container_start_page 2310
container_title Electroanalysis (New York, N.Y.)
container_volume 23
creator Santos, Paulina V. F.
Lopes , Ilanna C.
Diculescu, Victor C.
de Araújo, Mário César U.
Oliveira-Brett, Ana Maria
description The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected by the appearance of a new oxidation peak. The chemically degraded NOD (cdNOD), undergoes an irreversible, pH‐dependent oxidation, and its redox products are reversibly oxidised. The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed.
doi_str_mv 10.1002/elan.201100246
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1022850769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1022850769</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3606-1eb341542d4f360d30f252c3a44eddb5a2e56a87ea50dfb71bf51caf9d0caf493</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EEqWwMmdkSTk7dlJPqCptQUqLhKBILJYTX2ggH8VuRfvvSRRU2FjuztbznHQvIZcUBhSAXWOhqwED2j54eER6VDDqcwryuJmBgw-BjE7JmXPvACBDLnvk5hFNvfPmmK50lbvSeXXmLWqzLbTNK09XxhuvsMxTXRR77xbfrDZofolzcpLpwuHFT--T5-nkaXznxw-z-_Eo9tMghNCnmAScCs4Mz5oPE0DGBEsDzTkakwjNUIR6GKEWYLIkokkmaKozaaCpXAZ9ctXtXdv6c4tuo8rcpVg0N2O9dYoCY0MBUdiigw5Nbe2cxUytbV5qu28g1Yaj2qTUIalGkJ3wlRe4_4dWk3i0-Ov6nZu7De4OrrYfKoyCSKiXxUwt5fyVLWOqpsE33Kt7-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1022850769</pqid></control><display><type>article</type><title>Redox Mechanisms of Nodularin and Chemically Degraded Nodularin</title><source>Wiley Online Library All Journals</source><creator>Santos, Paulina V. F. ; Lopes , Ilanna C. ; Diculescu, Victor C. ; de Araújo, Mário César U. ; Oliveira-Brett, Ana Maria</creator><creatorcontrib>Santos, Paulina V. F. ; Lopes , Ilanna C. ; Diculescu, Victor C. ; de Araújo, Mário César U. ; Oliveira-Brett, Ana Maria</creatorcontrib><description>The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected by the appearance of a new oxidation peak. The chemically degraded NOD (cdNOD), undergoes an irreversible, pH‐dependent oxidation, and its redox products are reversibly oxidised. The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed.</description><identifier>ISSN: 1040-0397</identifier><identifier>EISSN: 1521-4109</identifier><identifier>DOI: 10.1002/elan.201100246</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Charge transfer ; Cyanobacteria ; Degradation ; Degradation products ; Electrochemical oxidation ; Electrodes ; Electrolytes ; Glassy carbon ; Metabolites ; Nodularin ; Oxidation ; pH effect</subject><ispartof>Electroanalysis (New York, N.Y.), 2011-10, Vol.23 (10), p.2310-2319</ispartof><rights>Copyright © 2011 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3606-1eb341542d4f360d30f252c3a44eddb5a2e56a87ea50dfb71bf51caf9d0caf493</citedby><cites>FETCH-LOGICAL-c3606-1eb341542d4f360d30f252c3a44eddb5a2e56a87ea50dfb71bf51caf9d0caf493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Felan.201100246$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Felan.201100246$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids></links><search><creatorcontrib>Santos, Paulina V. F.</creatorcontrib><creatorcontrib>Lopes , Ilanna C.</creatorcontrib><creatorcontrib>Diculescu, Victor C.</creatorcontrib><creatorcontrib>de Araújo, Mário César U.</creatorcontrib><creatorcontrib>Oliveira-Brett, Ana Maria</creatorcontrib><title>Redox Mechanisms of Nodularin and Chemically Degraded Nodularin</title><title>Electroanalysis (New York, N.Y.)</title><addtitle>Electroanalysis</addtitle><description>The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected by the appearance of a new oxidation peak. The chemically degraded NOD (cdNOD), undergoes an irreversible, pH‐dependent oxidation, and its redox products are reversibly oxidised. The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed.</description><subject>Charge transfer</subject><subject>Cyanobacteria</subject><subject>Degradation</subject><subject>Degradation products</subject><subject>Electrochemical oxidation</subject><subject>Electrodes</subject><subject>Electrolytes</subject><subject>Glassy carbon</subject><subject>Metabolites</subject><subject>Nodularin</subject><subject>Oxidation</subject><subject>pH effect</subject><issn>1040-0397</issn><issn>1521-4109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EEqWwMmdkSTk7dlJPqCptQUqLhKBILJYTX2ggH8VuRfvvSRRU2FjuztbznHQvIZcUBhSAXWOhqwED2j54eER6VDDqcwryuJmBgw-BjE7JmXPvACBDLnvk5hFNvfPmmK50lbvSeXXmLWqzLbTNK09XxhuvsMxTXRR77xbfrDZofolzcpLpwuHFT--T5-nkaXznxw-z-_Eo9tMghNCnmAScCs4Mz5oPE0DGBEsDzTkakwjNUIR6GKEWYLIkokkmaKozaaCpXAZ9ctXtXdv6c4tuo8rcpVg0N2O9dYoCY0MBUdiigw5Nbe2cxUytbV5qu28g1Yaj2qTUIalGkJ3wlRe4_4dWk3i0-Ov6nZu7De4OrrYfKoyCSKiXxUwt5fyVLWOqpsE33Kt7-g</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Santos, Paulina V. F.</creator><creator>Lopes , Ilanna C.</creator><creator>Diculescu, Victor C.</creator><creator>de Araújo, Mário César U.</creator><creator>Oliveira-Brett, Ana Maria</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>201110</creationdate><title>Redox Mechanisms of Nodularin and Chemically Degraded Nodularin</title><author>Santos, Paulina V. F. ; Lopes , Ilanna C. ; Diculescu, Victor C. ; de Araújo, Mário César U. ; Oliveira-Brett, Ana Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3606-1eb341542d4f360d30f252c3a44eddb5a2e56a87ea50dfb71bf51caf9d0caf493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Charge transfer</topic><topic>Cyanobacteria</topic><topic>Degradation</topic><topic>Degradation products</topic><topic>Electrochemical oxidation</topic><topic>Electrodes</topic><topic>Electrolytes</topic><topic>Glassy carbon</topic><topic>Metabolites</topic><topic>Nodularin</topic><topic>Oxidation</topic><topic>pH effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, Paulina V. F.</creatorcontrib><creatorcontrib>Lopes , Ilanna C.</creatorcontrib><creatorcontrib>Diculescu, Victor C.</creatorcontrib><creatorcontrib>de Araújo, Mário César U.</creatorcontrib><creatorcontrib>Oliveira-Brett, Ana Maria</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Electroanalysis (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Paulina V. F.</au><au>Lopes , Ilanna C.</au><au>Diculescu, Victor C.</au><au>de Araújo, Mário César U.</au><au>Oliveira-Brett, Ana Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Redox Mechanisms of Nodularin and Chemically Degraded Nodularin</atitle><jtitle>Electroanalysis (New York, N.Y.)</jtitle><addtitle>Electroanalysis</addtitle><date>2011-10</date><risdate>2011</risdate><volume>23</volume><issue>10</issue><spage>2310</spage><epage>2319</epage><pages>2310-2319</pages><issn>1040-0397</issn><eissn>1521-4109</eissn><abstract>The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected by the appearance of a new oxidation peak. The chemically degraded NOD (cdNOD), undergoes an irreversible, pH‐dependent oxidation, and its redox products are reversibly oxidised. The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/elan.201100246</doi><tpages>10</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1040-0397
ispartof Electroanalysis (New York, N.Y.), 2011-10, Vol.23 (10), p.2310-2319
issn 1040-0397
1521-4109
language eng
recordid cdi_proquest_miscellaneous_1022850769
source Wiley Online Library All Journals
subjects Charge transfer
Cyanobacteria
Degradation
Degradation products
Electrochemical oxidation
Electrodes
Electrolytes
Glassy carbon
Metabolites
Nodularin
Oxidation
pH effect
title Redox Mechanisms of Nodularin and Chemically Degraded Nodularin
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T13%3A16%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Redox%20Mechanisms%20of%20Nodularin%20and%20Chemically%20Degraded%20Nodularin&rft.jtitle=Electroanalysis%20(New%20York,%20N.Y.)&rft.au=Santos,%20Paulina%20V.%20F.&rft.date=2011-10&rft.volume=23&rft.issue=10&rft.spage=2310&rft.epage=2319&rft.pages=2310-2319&rft.issn=1040-0397&rft.eissn=1521-4109&rft_id=info:doi/10.1002/elan.201100246&rft_dat=%3Cproquest_cross%3E1022850769%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1022850769&rft_id=info:pmid/&rfr_iscdi=true