Redox Mechanisms of Nodularin and Chemically Degraded Nodularin
The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degr...
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Veröffentlicht in: | Electroanalysis (New York, N.Y.) N.Y.), 2011-10, Vol.23 (10), p.2310-2319 |
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creator | Santos, Paulina V. F. Lopes , Ilanna C. Diculescu, Victor C. de Araújo, Mário César U. Oliveira-Brett, Ana Maria |
description | The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected by the appearance of a new oxidation peak. The chemically degraded NOD (cdNOD), undergoes an irreversible, pH‐dependent oxidation, and its redox products are reversibly oxidised. The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed. |
doi_str_mv | 10.1002/elan.201100246 |
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F. ; Lopes , Ilanna C. ; Diculescu, Victor C. ; de Araújo, Mário César U. ; Oliveira-Brett, Ana Maria</creator><creatorcontrib>Santos, Paulina V. F. ; Lopes , Ilanna C. ; Diculescu, Victor C. ; de Araújo, Mário César U. ; Oliveira-Brett, Ana Maria</creatorcontrib><description>The electrochemical behaviour of Nodularin (NOD), a hepatotoxic cyclic pentapeptide, was studied at a glassy carbon electrode. NOD electrochemical oxidation is an irreversible, pH‐independent process, involving the transfer of one electron. Upon incubation in different pH electrolytes, chemical degradation of NOD was electrochemically detected by the appearance of a new oxidation peak. The chemically degraded NOD (cdNOD), undergoes an irreversible, pH‐dependent oxidation, and its redox products are reversibly oxidised. The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed.</description><identifier>ISSN: 1040-0397</identifier><identifier>EISSN: 1521-4109</identifier><identifier>DOI: 10.1002/elan.201100246</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Charge transfer ; Cyanobacteria ; Degradation ; Degradation products ; Electrochemical oxidation ; Electrodes ; Electrolytes ; Glassy carbon ; Metabolites ; Nodularin ; Oxidation ; pH effect</subject><ispartof>Electroanalysis (New York, N.Y.), 2011-10, Vol.23 (10), p.2310-2319</ispartof><rights>Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. 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The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed.</description><subject>Charge transfer</subject><subject>Cyanobacteria</subject><subject>Degradation</subject><subject>Degradation products</subject><subject>Electrochemical oxidation</subject><subject>Electrodes</subject><subject>Electrolytes</subject><subject>Glassy carbon</subject><subject>Metabolites</subject><subject>Nodularin</subject><subject>Oxidation</subject><subject>pH effect</subject><issn>1040-0397</issn><issn>1521-4109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EEqWwMmdkSTk7dlJPqCptQUqLhKBILJYTX2ggH8VuRfvvSRRU2FjuztbznHQvIZcUBhSAXWOhqwED2j54eER6VDDqcwryuJmBgw-BjE7JmXPvACBDLnvk5hFNvfPmmK50lbvSeXXmLWqzLbTNK09XxhuvsMxTXRR77xbfrDZofolzcpLpwuHFT--T5-nkaXznxw-z-_Eo9tMghNCnmAScCs4Mz5oPE0DGBEsDzTkakwjNUIR6GKEWYLIkokkmaKozaaCpXAZ9ctXtXdv6c4tuo8rcpVg0N2O9dYoCY0MBUdiigw5Nbe2cxUytbV5qu28g1Yaj2qTUIalGkJ3wlRe4_4dWk3i0-Ov6nZu7De4OrrYfKoyCSKiXxUwt5fyVLWOqpsE33Kt7-g</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Santos, Paulina V. 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F.</creatorcontrib><creatorcontrib>Lopes , Ilanna C.</creatorcontrib><creatorcontrib>Diculescu, Victor C.</creatorcontrib><creatorcontrib>de Araújo, Mário César U.</creatorcontrib><creatorcontrib>Oliveira-Brett, Ana Maria</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Electroanalysis (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Paulina V. 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The chemically degraded NOD (cdNOD), undergoes an irreversible, pH‐dependent oxidation, and its redox products are reversibly oxidised. The charge transfer properties of cdNOD as well as of its redox metabolites were investigated. Mechanisms for NOD oxidation, NOD chemical degradation and oxidation of cdNOD and its metabolites were proposed.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/elan.201100246</doi><tpages>10</tpages></addata></record> |
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subjects | Charge transfer Cyanobacteria Degradation Degradation products Electrochemical oxidation Electrodes Electrolytes Glassy carbon Metabolites Nodularin Oxidation pH effect |
title | Redox Mechanisms of Nodularin and Chemically Degraded Nodularin |
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