The influence of treatments in daily clinical practice on the Children's Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry
Summary Background Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study. Objectives To assess the Children’s Dermatology Life Quality Index (CDLQI) in a co...
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| Veröffentlicht in: | British journal of dermatology (1951) 2012-07, Vol.167 (1), p.145-149 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 167 |
| creator | Oostveen, A.M. de Jager, M.E.A. van de Kerkhof, P.C.M. Donders, A.R.T. de Jong, E.M.G.J. Seyger, M.M.B. |
| description | Summary
Background Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study.
Objectives To assess the Children’s Dermatology Life Quality Index (CDLQI) in a cohort of patients with juvenile psoriasis and to evaluate the influence of treatments in daily clinical practice on CDLQI.
Methods We conducted a prospective observational study of children with psoriasis from a registry containing daily clinical practice data. Before and after treatment, QoL was assessed by the CDLQI and disease severity was documented by the Psoriasis Area and Severity Index (PASI). Three clusters of treatments were analysed: topical, dithranol and systemic therapy.
Results In total, 125 patients were enrolled in the registry. Cross‐sectionally, a mean ± SD CDLQI score of 7·5 ± 5·0 and a mean ± SD PASI of 7·0 ± 5·8 were recorded. Itching and problems with treatment had the highest impact on the children’s QoL. Longitudinally, 85 patients were analysed with a total of 137 treatment episodes. All treatments contributed to a significant decline in total CDLQI score, with the largest decrease seen in dithranol and systemic treatments. A significant correlation was found between ΔCDLQI and ΔPASI for all treatment modalities. The highest positive impact of treatments was found in a decline of itch and sleep disturbance.
Conclusions In this first prospective observational study on CDLQI in juvenile psoriasis, a positive influence of treatments in daily clinical practice on QoL was demonstrated. |
| doi_str_mv | 10.1111/j.1365-2133.2012.10996.x |
| format | Article |
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Background Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study.
Objectives To assess the Children’s Dermatology Life Quality Index (CDLQI) in a cohort of patients with juvenile psoriasis and to evaluate the influence of treatments in daily clinical practice on CDLQI.
Methods We conducted a prospective observational study of children with psoriasis from a registry containing daily clinical practice data. Before and after treatment, QoL was assessed by the CDLQI and disease severity was documented by the Psoriasis Area and Severity Index (PASI). Three clusters of treatments were analysed: topical, dithranol and systemic therapy.
Results In total, 125 patients were enrolled in the registry. Cross‐sectionally, a mean ± SD CDLQI score of 7·5 ± 5·0 and a mean ± SD PASI of 7·0 ± 5·8 were recorded. Itching and problems with treatment had the highest impact on the children’s QoL. Longitudinally, 85 patients were analysed with a total of 137 treatment episodes. All treatments contributed to a significant decline in total CDLQI score, with the largest decrease seen in dithranol and systemic treatments. A significant correlation was found between ΔCDLQI and ΔPASI for all treatment modalities. The highest positive impact of treatments was found in a decline of itch and sleep disturbance.
Conclusions In this first prospective observational study on CDLQI in juvenile psoriasis, a positive influence of treatments in daily clinical practice on QoL was demonstrated.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2012.10996.x</identifier><identifier>PMID: 22616669</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Cutaneous ; Adolescent ; Age of Onset ; Biological and medical sciences ; Child ; Child, Preschool ; Cross-Sectional Studies ; Dermatologic Agents - therapeutic use ; Dermatology ; General aspects ; Humans ; Medical sciences ; Prospective Studies ; Psoriasis - drug therapy ; Psoriasis - psychology ; Psoriasis. Parapsoriasis. Lichen ; Quality of Life ; Registries ; Severity of Illness Index</subject><ispartof>British journal of dermatology (1951), 2012-07, Vol.167 (1), p.145-149</ispartof><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3896-e3b6eb609e30cc993eaaf8837a204bb092928953a4ef31bb29a2bd2ed31275c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2012.10996.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2012.10996.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26143932$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22616669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oostveen, A.M.</creatorcontrib><creatorcontrib>de Jager, M.E.A.</creatorcontrib><creatorcontrib>van de Kerkhof, P.C.M.</creatorcontrib><creatorcontrib>Donders, A.R.T.</creatorcontrib><creatorcontrib>de Jong, E.M.G.J.</creatorcontrib><creatorcontrib>Seyger, M.M.B.</creatorcontrib><title>The influence of treatments in daily clinical practice on the Children's Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study.
Objectives To assess the Children’s Dermatology Life Quality Index (CDLQI) in a cohort of patients with juvenile psoriasis and to evaluate the influence of treatments in daily clinical practice on CDLQI.
Methods We conducted a prospective observational study of children with psoriasis from a registry containing daily clinical practice data. Before and after treatment, QoL was assessed by the CDLQI and disease severity was documented by the Psoriasis Area and Severity Index (PASI). Three clusters of treatments were analysed: topical, dithranol and systemic therapy.
Results In total, 125 patients were enrolled in the registry. Cross‐sectionally, a mean ± SD CDLQI score of 7·5 ± 5·0 and a mean ± SD PASI of 7·0 ± 5·8 were recorded. Itching and problems with treatment had the highest impact on the children’s QoL. Longitudinally, 85 patients were analysed with a total of 137 treatment episodes. All treatments contributed to a significant decline in total CDLQI score, with the largest decrease seen in dithranol and systemic treatments. A significant correlation was found between ΔCDLQI and ΔPASI for all treatment modalities. The highest positive impact of treatments was found in a decline of itch and sleep disturbance.
Conclusions In this first prospective observational study on CDLQI in juvenile psoriasis, a positive influence of treatments in daily clinical practice on QoL was demonstrated.</description><subject>Administration, Cutaneous</subject><subject>Adolescent</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Dermatologic Agents - therapeutic use</subject><subject>Dermatology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - psychology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Quality of Life</subject><subject>Registries</subject><subject>Severity of Illness Index</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkt9u0zAUhyMEYmXwCsg3CG5S_Kdxai6QRjbGpgrY1AHixnKSk87FcYrtQPNsvNyctXS-seXz-ZP1OydJEMFTEtfb9ZQwnqWUMDalmNApwULw6fZRMjkUHicTjHGeYsHZUfLM-zXGhOEMP02OKOWEcy4myb_lLSBtG9ODrQB1DQoOVGjBBh_vUa20GVBltNWVMmjjVBX0CFoU4sviVpvagX3t0Sm4VoXOdKsBLXQD6KpXRocBXdgatqNr3f8Bqw2gje-cVl77d0gh09mVDn2tbfT7eBhQ47r2QZ8WJ1-XN9dnaKOCjv9CDlbaBzc8T540ynh4sd-Pk5uPZ8viU7r4cn5RnCzSis0FT4GVHEqOBTBcVUIwUKqZz1muKJ6VJRZU0LnImJpBw0hZUqFoWVOoGaF5VuXsOHmz825c97sHH2SrfQXGKAtd7yXBlM5nOaZZRF_u0b5soZYbp1vlBvk_8Ai82gPKx0Abp2yl_QPHyYwJRiP3fsf9jYENhzrBchwAuZZjn-XYZzkOgLwfALmVHy5P749RkO4EMSrYHgTK_ZI8Z3kmv38-l98Ev_55lRfyB7sDJoK1yQ</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Oostveen, A.M.</creator><creator>de Jager, M.E.A.</creator><creator>van de Kerkhof, P.C.M.</creator><creator>Donders, A.R.T.</creator><creator>de Jong, E.M.G.J.</creator><creator>Seyger, M.M.B.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>The influence of treatments in daily clinical practice on the Children's Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry</title><author>Oostveen, A.M. ; de Jager, M.E.A. ; van de Kerkhof, P.C.M. ; Donders, A.R.T. ; de Jong, E.M.G.J. ; Seyger, M.M.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3896-e3b6eb609e30cc993eaaf8837a204bb092928953a4ef31bb29a2bd2ed31275c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Cutaneous</topic><topic>Adolescent</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Dermatologic Agents - therapeutic use</topic><topic>Dermatology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - psychology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Quality of Life</topic><topic>Registries</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oostveen, A.M.</creatorcontrib><creatorcontrib>de Jager, M.E.A.</creatorcontrib><creatorcontrib>van de Kerkhof, P.C.M.</creatorcontrib><creatorcontrib>Donders, A.R.T.</creatorcontrib><creatorcontrib>de Jong, E.M.G.J.</creatorcontrib><creatorcontrib>Seyger, M.M.B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oostveen, A.M.</au><au>de Jager, M.E.A.</au><au>van de Kerkhof, P.C.M.</au><au>Donders, A.R.T.</au><au>de Jong, E.M.G.J.</au><au>Seyger, M.M.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of treatments in daily clinical practice on the Children's Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2012-07</date><risdate>2012</risdate><volume>167</volume><issue>1</issue><spage>145</spage><epage>149</epage><pages>145-149</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Juvenile psoriasis has a negative effect on the quality of life (QoL). The influence of treatments on QoL of these children has never been investigated before in a prospective observational study.
Objectives To assess the Children’s Dermatology Life Quality Index (CDLQI) in a cohort of patients with juvenile psoriasis and to evaluate the influence of treatments in daily clinical practice on CDLQI.
Methods We conducted a prospective observational study of children with psoriasis from a registry containing daily clinical practice data. Before and after treatment, QoL was assessed by the CDLQI and disease severity was documented by the Psoriasis Area and Severity Index (PASI). Three clusters of treatments were analysed: topical, dithranol and systemic therapy.
Results In total, 125 patients were enrolled in the registry. Cross‐sectionally, a mean ± SD CDLQI score of 7·5 ± 5·0 and a mean ± SD PASI of 7·0 ± 5·8 were recorded. Itching and problems with treatment had the highest impact on the children’s QoL. Longitudinally, 85 patients were analysed with a total of 137 treatment episodes. All treatments contributed to a significant decline in total CDLQI score, with the largest decrease seen in dithranol and systemic treatments. A significant correlation was found between ΔCDLQI and ΔPASI for all treatment modalities. The highest positive impact of treatments was found in a decline of itch and sleep disturbance.
Conclusions In this first prospective observational study on CDLQI in juvenile psoriasis, a positive influence of treatments in daily clinical practice on QoL was demonstrated.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22616669</pmid><doi>10.1111/j.1365-2133.2012.10996.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2012-07, Vol.167 (1), p.145-149 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Administration, Cutaneous Adolescent Age of Onset Biological and medical sciences Child Child, Preschool Cross-Sectional Studies Dermatologic Agents - therapeutic use Dermatology General aspects Humans Medical sciences Prospective Studies Psoriasis - drug therapy Psoriasis - psychology Psoriasis. Parapsoriasis. Lichen Quality of Life Registries Severity of Illness Index |
| title | The influence of treatments in daily clinical practice on the Children's Dermatology Life Quality Index in juvenile psoriasis: a longitudinal study from the Child-CAPTURE patient registry |
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