The metastatic microenvironment: Brain-residing melanoma metastasis and dormant micrometastasis

Brain metastasis occurs frequently in melanoma patients with advanced disease whereby the prognosis is dismal. The underlying mechanisms of melanoma brain metastasis development are not well understood. We generated a reproducible melanoma brain metastasis model, consisting of brain‐metastasizing va...

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Veröffentlicht in:	International journal of cancer 2012-09, Vol.131 (5), p.1071-1082
Hauptverfasser:	Izraely, Sivan, Sagi-Assif, Orit, Klein, Anat, Meshel, Tsipi, Tsarfaty, Galia, Pasmanik-Chor, Metsada, Nahmias, Clara, Couraud, Pierre-Olivier, Ateh, Eugene, Bryant, Joseph L., Hoon, Dave S.B., Witz, Isaac P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Brain cancer brain metastasis Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - secondary Cancer Cell Adhesion Cell Proliferation dormancy Flow Cytometry Gene Expression Profiling Humans Immunoenzyme Techniques Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - secondary Magnetic Resonance Imaging Male Medical research Medical sciences Melanoma Melanoma - genetics Melanoma - metabolism Melanoma - pathology Metastasis Mice Mice, Inbred BALB C micrometastasis Neoplasm Micrometastasis Neoplasm Transplantation Neurology Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - secondary Tumor Cells, Cultured Tumors Tumors of the nervous system. Phacomatoses xenograft model
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