Porous silicone hydrogel interpenetrating polymer networks prepared using a template method for biomedical use
Porous interpenetrating polymer networks (IPNs) of polydimethylsiloxane with hydrophilic components synthesized by radical homopolymerization and copolymerization of 2‐hydroxyethyl methacrylate (HEMA) and N,N‐dimethylacrylamide (DMAA) were obtained using a template method. Surface modification of Ca...
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| Veröffentlicht in: | Polymer international 2011-07, Vol.60 (7), p.1136-1141 |
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| creator | Tang, Qi Yu, Jun-Rong Chen, Lei Zhu, Jing Hu, Zu-Ming |
| description | Porous interpenetrating polymer networks (IPNs) of polydimethylsiloxane with hydrophilic components synthesized by radical homopolymerization and copolymerization of 2‐hydroxyethyl methacrylate (HEMA) and N,N‐dimethylacrylamide (DMAA) were obtained using a template method. Surface modification of CaCO3 microsphere templates improved their dispersibility, leading to the realization of IPN films with an interconnected porous structure. Results showed that these porous IPN films exhibited higher swelling abilities, and thus better drug loading capabilities than the corresponding non‐porous films. In addition, IPNs comprised of DMAA exhibited higher swelling abilities and faster drug release rates than those of only HEMA. These silicone hydrogels were also tested for their cytotoxicity against L929 cells, confirming their non‐toxicity to cells and their potential use as materials for biomedical applications. Copyright © 2011 Society of Chemical Industry
Porous interpenetrating polymer networks of polydimethylsiloxane with hydrophilic components were prepared using a template method. |
| doi_str_mv | 10.1002/pi.3053 |
| format | Article |
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Porous interpenetrating polymer networks of polydimethylsiloxane with hydrophilic components were prepared using a template method.</description><identifier>ISSN: 0959-8103</identifier><identifier>EISSN: 1097-0126</identifier><identifier>DOI: 10.1002/pi.3053</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Applied sciences ; Biological and medical sciences ; Biomedical materials ; cytotoxicity ; drug release ; Drugs ; Exact sciences and technology ; General pharmacology ; Hydrogels ; Inorganic and organomineral polymers ; Interpenetrating networks ; IPN ; Medical sciences ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polymers ; porous ; Properties and characterization ; Radicals ; silicone hydrogel ; Silicones ; Solution and gel properties ; Swelling</subject><ispartof>Polymer international, 2011-07, Vol.60 (7), p.1136-1141</ispartof><rights>Copyright © 2011 Society of Chemical Industry</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3623-b12a3d79236e8fa362477c4c5b220f3e307b693df3298a1753949588bc35068a3</citedby><cites>FETCH-LOGICAL-c3623-b12a3d79236e8fa362477c4c5b220f3e307b693df3298a1753949588bc35068a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpi.3053$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpi.3053$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27925,27926,45575,45576</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24249954$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Qi</creatorcontrib><creatorcontrib>Yu, Jun-Rong</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Zhu, Jing</creatorcontrib><creatorcontrib>Hu, Zu-Ming</creatorcontrib><title>Porous silicone hydrogel interpenetrating polymer networks prepared using a template method for biomedical use</title><title>Polymer international</title><addtitle>Polym. Int</addtitle><description>Porous interpenetrating polymer networks (IPNs) of polydimethylsiloxane with hydrophilic components synthesized by radical homopolymerization and copolymerization of 2‐hydroxyethyl methacrylate (HEMA) and N,N‐dimethylacrylamide (DMAA) were obtained using a template method. Surface modification of CaCO3 microsphere templates improved their dispersibility, leading to the realization of IPN films with an interconnected porous structure. Results showed that these porous IPN films exhibited higher swelling abilities, and thus better drug loading capabilities than the corresponding non‐porous films. In addition, IPNs comprised of DMAA exhibited higher swelling abilities and faster drug release rates than those of only HEMA. These silicone hydrogels were also tested for their cytotoxicity against L929 cells, confirming their non‐toxicity to cells and their potential use as materials for biomedical applications. Copyright © 2011 Society of Chemical Industry
Porous interpenetrating polymer networks of polydimethylsiloxane with hydrophilic components were prepared using a template method.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>cytotoxicity</subject><subject>drug release</subject><subject>Drugs</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Hydrogels</subject><subject>Inorganic and organomineral polymers</subject><subject>Interpenetrating networks</subject><subject>IPN</subject><subject>Medical sciences</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polymers</subject><subject>porous</subject><subject>Properties and characterization</subject><subject>Radicals</subject><subject>silicone hydrogel</subject><subject>Silicones</subject><subject>Solution and gel properties</subject><subject>Swelling</subject><issn>0959-8103</issn><issn>1097-0126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp10FFrFDEQB_AgFjxb8SvkRRRka5LZ7G4e5ai1cOgVqj6GbHa2jc1uYrJHvW9vjjv65tPAf378YYaQt5xdcsbEp-gugUl4QVacqbZiXDQvyYopqaqOM3hFXuf8mzHWKaVWZN6GFHaZZuedDTPSh_2Qwj166uYFU8QZl2QWN9_TGPx-wkRL8hTSY6YxYTQJB7rLh72hC07RmwXphMtDGOgYEu1dmHBw1vjC8IKcjcZnfHOa5-THl6u79ddq8_36Zv15U1loBFQ9FwaGVglosBtNyeq2tbWVvRBsBATW9o2CYQShOsNbCapWsut6C5I1nYFz8uHYG1P4s8O86Mlli96bGcu5mjMhuloCV4W-P1KbQs4JRx2Tm0zaF6QPH9XR6cNHi3x3KjW53DMmM1uXn7moRa2UrIv7eHRPzuP-f3V6e3NqrY7a5QX_PmuTHnXTQiv1r2_XmsnbNfzcbLWCfwoEkzs</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Tang, Qi</creator><creator>Yu, Jun-Rong</creator><creator>Chen, Lei</creator><creator>Zhu, Jing</creator><creator>Hu, Zu-Ming</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>201107</creationdate><title>Porous silicone hydrogel interpenetrating polymer networks prepared using a template method for biomedical use</title><author>Tang, Qi ; Yu, Jun-Rong ; Chen, Lei ; Zhu, Jing ; Hu, Zu-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3623-b12a3d79236e8fa362477c4c5b220f3e307b693df3298a1753949588bc35068a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>cytotoxicity</topic><topic>drug release</topic><topic>Drugs</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Hydrogels</topic><topic>Inorganic and organomineral polymers</topic><topic>Interpenetrating networks</topic><topic>IPN</topic><topic>Medical sciences</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polymers</topic><topic>porous</topic><topic>Properties and characterization</topic><topic>Radicals</topic><topic>silicone hydrogel</topic><topic>Silicones</topic><topic>Solution and gel properties</topic><topic>Swelling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Qi</creatorcontrib><creatorcontrib>Yu, Jun-Rong</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><creatorcontrib>Zhu, Jing</creatorcontrib><creatorcontrib>Hu, Zu-Ming</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymer international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Qi</au><au>Yu, Jun-Rong</au><au>Chen, Lei</au><au>Zhu, Jing</au><au>Hu, Zu-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porous silicone hydrogel interpenetrating polymer networks prepared using a template method for biomedical use</atitle><jtitle>Polymer international</jtitle><addtitle>Polym. Int</addtitle><date>2011-07</date><risdate>2011</risdate><volume>60</volume><issue>7</issue><spage>1136</spage><epage>1141</epage><pages>1136-1141</pages><issn>0959-8103</issn><eissn>1097-0126</eissn><abstract>Porous interpenetrating polymer networks (IPNs) of polydimethylsiloxane with hydrophilic components synthesized by radical homopolymerization and copolymerization of 2‐hydroxyethyl methacrylate (HEMA) and N,N‐dimethylacrylamide (DMAA) were obtained using a template method. Surface modification of CaCO3 microsphere templates improved their dispersibility, leading to the realization of IPN films with an interconnected porous structure. Results showed that these porous IPN films exhibited higher swelling abilities, and thus better drug loading capabilities than the corresponding non‐porous films. In addition, IPNs comprised of DMAA exhibited higher swelling abilities and faster drug release rates than those of only HEMA. These silicone hydrogels were also tested for their cytotoxicity against L929 cells, confirming their non‐toxicity to cells and their potential use as materials for biomedical applications. Copyright © 2011 Society of Chemical Industry
Porous interpenetrating polymer networks of polydimethylsiloxane with hydrophilic components were prepared using a template method.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/pi.3053</doi><tpages>6</tpages></addata></record> |
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| subjects | Applied sciences Biological and medical sciences Biomedical materials cytotoxicity drug release Drugs Exact sciences and technology General pharmacology Hydrogels Inorganic and organomineral polymers Interpenetrating networks IPN Medical sciences Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers porous Properties and characterization Radicals silicone hydrogel Silicones Solution and gel properties Swelling |
| title | Porous silicone hydrogel interpenetrating polymer networks prepared using a template method for biomedical use |
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