miRNA-125b regulates TNF-α production in CD14+ neonatal monocytes via post-transcriptional regulation

Neonatal monocytes express lower miR‐125b, a negative regulator of TNF‐α expression, resulting in higher TNF‐α responses after LPS stimulation. Neonates, although deficient in cell immunity, frequently reveal sepsis with augmented proinflammatory reactions. Here, we found that neonatal monocytes pro...

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Veröffentlicht in:	Journal of leukocyte biology 2012-07, Vol.92 (1), p.171-182
Hauptverfasser:	Huang, Hsin‐Chun, Yu, Hong‐Ren, Huang, Li‐Tung, Huang, Hui‐Chen, Chen, Ron‐Fu, Lin, I‐Chun, Ou, Chia‐Yo, Hsu, Te‐Yao, Yang, Kuender D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers - metabolism Blotting, Western Cells, Cultured cord blood Endotoxins - pharmacology Enzyme-Linked Immunosorbent Assay epigenetics Female Fetal Blood Flow Cytometry Gene Expression Profiling Humans Infant, Newborn Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - pharmacology MicroRNAs - genetics Monocytes - cytology Monocytes - drug effects Monocytes - metabolism neonate NF-kappa B - genetics NF-kappa B - metabolism Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA Processing, Post-Transcriptional RNA, Messenger - genetics sepsis Tumor Necrosis Factor-alpha - metabolism
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