Epitopes, avidity and IgG subclasses of tyrosine hydroxylase autoantibodies in vitiligo and alopecia areata patients

Summary Background We previously detected antibodies against tyrosine hydroxylase (TH) in 23% of patients with nonsegmental vitiligo and in 19% of patients with alopecia areata (AA). Objectives To identify TH epitopes recognized by TH antibodies in patients with vitiligo and AA. Methods Recombina...

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Veröffentlicht in:	British journal of dermatology (1951) 2012-07, Vol.167 (1), p.17-28
Hauptverfasser:	Rahoma, S.F.E., Sandhu, H.K., McDonagh, A.J.G., Gawkrodger, D.J., Weetman, A.P., Kemp, E.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alopecia Areata - immunology Autoantibodies - metabolism Binding Sites Biological and medical sciences Child Child, Preschool Dermatology DNA, Complementary - metabolism Enzyme-Linked Immunosorbent Assay Epitopes, B-Lymphocyte - metabolism Female Hair and nails disorders Humans Immunoglobulin G - classification Immunoglobulin G - metabolism Male Medical sciences Middle Aged Pigmentary diseases of the skin Radioimmunoassay Tyrosine 3-Monooxygenase - immunology Vitiligo - immunology Young Adult
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