12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

Noninflammatory clearance of apoptotic cells (ACs) is crucial to maintain self-tolerance. Here, we have reported a role for the enzyme 12/15-lipoxygenase (12/15-LO) as a central factor governing the sorting of ACs into differentially activated monocyte subpopulations. During inflammation, uptake of...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2012-05, Vol.36 (5), p.834-846
Hauptverfasser:	Uderhardt, Stefan, Herrmann, Martin, Oskolkova, Olga V., Aschermann, Susanne, Bicker, Wolfgang, Ipseiz, Natacha, Sarter, Kerstin, Frey, Benjamin, Rothe, Tobias, Voll, Reinhard, Nimmerjahn, Falk, Bochkov, Valery N., Schett, Georg, Krönke, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen presentation Apoptosis Apoptosis - immunology Arachidonate 12-lipoxygenase Arachidonate 12-Lipoxygenase - immunology Arachidonate 12-Lipoxygenase - metabolism Arachidonate 15-Lipoxygenase - immunology Arachidonate 15-Lipoxygenase - metabolism Autoimmune diseases Data processing Enzymes Experiments Female Homeostasis Immunological tolerance Inflammation Inflammation - immunology Inflammation - metabolism Inflammation - pathology Lipid Metabolism - immunology Lipid peroxidation Lipids Lipids - immunology Macrophage Activation - immunology Macrophages Macrophages - cytology Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL Microscopy Milk Monocytes Monocytes - cytology Monocytes - immunology Monocytes - metabolism Oxidation-Reduction Phagocytosis phosphatidylethanolamine Population Self Tolerance - immunology
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