Differential expression of cathepsin K in neoplasms harboring TFE3 gene fusions

Cathepsin K is a protease whose expression is driven by microphthalmia transcription factor (MITF) in osteoclasts. TFE3 and TFEB are members of the same transcription factor subfamily as MITF and all three have overlapping transcriptional targets. We have shown that all t(6;11) renal cell carcinomas...

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Veröffentlicht in:	Modern pathology 2011-10, Vol.24 (10), p.1313-1319
Hauptverfasser:	Martignoni, Guido, Gobbo, Stefano, Camparo, Philippe, Brunelli, Matteo, Munari, Enrico, Segala, Diego, Pea, Maurizio, Bonetti, Franco, Illei, Peter B, Netto, Georges J, Ladanyi, Marc, Chilosi, Marco, Argani, Pedram
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/199 692/699/67/589/1588/1351 692/700/139/422 Adolescent Adult Aged Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Bone (alveolar) Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cathepsin K Cathepsin K - analysis Cell Cycle Proteins - genetics Child Chromosomes, Human, Pair 11 Chromosomes, Human, X Clear cells Cytology Differential diagnosis Female Fusion protein Gene Fusion Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins Kidney cancer Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Laboratory Medicine Male Medicine Medicine & Public Health Metastases Microphthalmia-associated transcription factor Middle Aged Neoplasm Proteins - genetics Oncogene Proteins, Fusion - genetics original-article Osteoclasts Pathology Proteinase Proteins renal cell carcinoma Sarcoma Sarcoma, Alveolar Soft Part - enzymology Sarcoma, Alveolar Soft Part - genetics Sarcoma, Alveolar Soft Part - pathology Transcription factors Translocation Translocation, Genetic Tumors Young Adult
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