Cognitive function in adult offspring of women with Type1 diabetes
Aims Maternal diabetes may affect offspring cognitive function. The objective of the study was to evaluate cognitive function and potential predictors hereof in adult offspring of women with Type1 diabetes. Methods We conducted a follow-up study of adult offspring of women with Type1 diabetes (n=158...
Gespeichert in:
| Veröffentlicht in: | Diabetic medicine 2011-07, Vol.28 (7), p.838-844 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 844 |
|---|---|
| container_issue | 7 |
| container_start_page | 838 |
| container_title | Diabetic medicine |
| container_volume | 28 |
| creator | Clausen, T D Mortensen, EL Schmidt, L Mathiesen, E R Hansen, T Jensen, D M Holm, S Poulsen, L From, M Damm, P |
| description | Aims Maternal diabetes may affect offspring cognitive function. The objective of the study was to evaluate cognitive function and potential predictors hereof in adult offspring of women with Type1 diabetes. Methods We conducted a follow-up study of adult offspring of women with Type1 diabetes (n=158) and a reference group from the background population (n=118). The main outcome measure was offspring cognitive function measured by global cognitive score, derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Results Offspring of women with Type1 diabetes obtained lower global cognitive scores (94.8 vs. 100.0, P=0.004) than offspring from the background population. When adjusted for confounders, the groups no longer differed significantly (difference 0.4, 95%CI -3.3 to 4.). Positive predictors of cognitive function in offspring of women with diabetes were family social class, parental educational level, maternal diabetes duration, male gender and offspring age, whereas parity greater than or equal to 1 and gestational age |
| doi_str_mv | 10.1111/j.1464-5491.2011.03300.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_1022563292</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1022563292</sourcerecordid><originalsourceid>FETCH-LOGICAL-p103t-910d82264679ddefa16d6879c5d940d547464835ef389deedfff1b4ba8c85ac93</originalsourceid><addsrcrecordid>eNo9jk1LxDAURYMoWEf_Q5ZuWt9L0o8sdVBHGHAzroe0eRkzdNI6SR399xYU7-YeuHC4jHGEAufc7QtUlcpLpbEQgFiAlADF1xnL_odzlkGtRC6hxkt2FeMeAIWWOmMPy2EXfPKfxN0UuuSHwH3gxk594oNzcTz6sJuJn4YDBX7y6Z1vvkdCbr1pKVG8ZhfO9JFu_nrB3p4eN8tVvn59flner_MRQaZcI9hGiEpVtbaWnMHKVk2tu9JqBbZU9Xy3kSU52WhLZJ1z2KrWNF1Tmk7LBbv99Y7H4WOimLYHHzvqexNomOIWQYiykkIL-QMlZVAF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1022563292</pqid></control><display><type>article</type><title>Cognitive function in adult offspring of women with Type1 diabetes</title><source>Wiley Journals</source><creator>Clausen, T D ; Mortensen, EL ; Schmidt, L ; Mathiesen, E R ; Hansen, T ; Jensen, D M ; Holm, S ; Poulsen, L ; From, M ; Damm, P</creator><creatorcontrib>Clausen, T D ; Mortensen, EL ; Schmidt, L ; Mathiesen, E R ; Hansen, T ; Jensen, D M ; Holm, S ; Poulsen, L ; From, M ; Damm, P</creatorcontrib><description>Aims Maternal diabetes may affect offspring cognitive function. The objective of the study was to evaluate cognitive function and potential predictors hereof in adult offspring of women with Type1 diabetes. Methods We conducted a follow-up study of adult offspring of women with Type1 diabetes (n=158) and a reference group from the background population (n=118). The main outcome measure was offspring cognitive function measured by global cognitive score, derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Results Offspring of women with Type1 diabetes obtained lower global cognitive scores (94.8 vs. 100.0, P=0.004) than offspring from the background population. When adjusted for confounders, the groups no longer differed significantly (difference 0.4, 95%CI -3.3 to 4.). Positive predictors of cognitive function in offspring of women with diabetes were family social class, parental educational level, maternal diabetes duration, male gender and offspring age, whereas parity greater than or equal to 1 and gestational age <34weeks were negative predictors. We found no association with maternal glycaemia during pregnancy or with neonatal hypoglycaemia. Conclusions Impaired cognitive function in adult offspring of women with Type1 diabetes compared with the background population apparently reflects differences with respect to well-known confounders. However, harmful effects of maternal hyperglycaemia may be mediated through delivery at <34weeks.Original Abstract: Diabet. Med. 28, 838-844 (2011)</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2011.03300.x</identifier><language>eng</language><subject>Age ; Cognitive ability ; Diabetes mellitus ; Gestational age ; Intelligence ; Neonates ; Parity ; Pregnancy ; Progeny</subject><ispartof>Diabetic medicine, 2011-07, Vol.28 (7), p.838-844</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Clausen, T D</creatorcontrib><creatorcontrib>Mortensen, EL</creatorcontrib><creatorcontrib>Schmidt, L</creatorcontrib><creatorcontrib>Mathiesen, E R</creatorcontrib><creatorcontrib>Hansen, T</creatorcontrib><creatorcontrib>Jensen, D M</creatorcontrib><creatorcontrib>Holm, S</creatorcontrib><creatorcontrib>Poulsen, L</creatorcontrib><creatorcontrib>From, M</creatorcontrib><creatorcontrib>Damm, P</creatorcontrib><title>Cognitive function in adult offspring of women with Type1 diabetes</title><title>Diabetic medicine</title><description>Aims Maternal diabetes may affect offspring cognitive function. The objective of the study was to evaluate cognitive function and potential predictors hereof in adult offspring of women with Type1 diabetes. Methods We conducted a follow-up study of adult offspring of women with Type1 diabetes (n=158) and a reference group from the background population (n=118). The main outcome measure was offspring cognitive function measured by global cognitive score, derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Results Offspring of women with Type1 diabetes obtained lower global cognitive scores (94.8 vs. 100.0, P=0.004) than offspring from the background population. When adjusted for confounders, the groups no longer differed significantly (difference 0.4, 95%CI -3.3 to 4.). Positive predictors of cognitive function in offspring of women with diabetes were family social class, parental educational level, maternal diabetes duration, male gender and offspring age, whereas parity greater than or equal to 1 and gestational age <34weeks were negative predictors. We found no association with maternal glycaemia during pregnancy or with neonatal hypoglycaemia. Conclusions Impaired cognitive function in adult offspring of women with Type1 diabetes compared with the background population apparently reflects differences with respect to well-known confounders. However, harmful effects of maternal hyperglycaemia may be mediated through delivery at <34weeks.Original Abstract: Diabet. Med. 28, 838-844 (2011)</description><subject>Age</subject><subject>Cognitive ability</subject><subject>Diabetes mellitus</subject><subject>Gestational age</subject><subject>Intelligence</subject><subject>Neonates</subject><subject>Parity</subject><subject>Pregnancy</subject><subject>Progeny</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNo9jk1LxDAURYMoWEf_Q5ZuWt9L0o8sdVBHGHAzroe0eRkzdNI6SR399xYU7-YeuHC4jHGEAufc7QtUlcpLpbEQgFiAlADF1xnL_odzlkGtRC6hxkt2FeMeAIWWOmMPy2EXfPKfxN0UuuSHwH3gxk594oNzcTz6sJuJn4YDBX7y6Z1vvkdCbr1pKVG8ZhfO9JFu_nrB3p4eN8tVvn59flner_MRQaZcI9hGiEpVtbaWnMHKVk2tu9JqBbZU9Xy3kSU52WhLZJ1z2KrWNF1Tmk7LBbv99Y7H4WOimLYHHzvqexNomOIWQYiykkIL-QMlZVAF</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Clausen, T D</creator><creator>Mortensen, EL</creator><creator>Schmidt, L</creator><creator>Mathiesen, E R</creator><creator>Hansen, T</creator><creator>Jensen, D M</creator><creator>Holm, S</creator><creator>Poulsen, L</creator><creator>From, M</creator><creator>Damm, P</creator><scope>7TK</scope></search><sort><creationdate>20110701</creationdate><title>Cognitive function in adult offspring of women with Type1 diabetes</title><author>Clausen, T D ; Mortensen, EL ; Schmidt, L ; Mathiesen, E R ; Hansen, T ; Jensen, D M ; Holm, S ; Poulsen, L ; From, M ; Damm, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p103t-910d82264679ddefa16d6879c5d940d547464835ef389deedfff1b4ba8c85ac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age</topic><topic>Cognitive ability</topic><topic>Diabetes mellitus</topic><topic>Gestational age</topic><topic>Intelligence</topic><topic>Neonates</topic><topic>Parity</topic><topic>Pregnancy</topic><topic>Progeny</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Clausen, T D</creatorcontrib><creatorcontrib>Mortensen, EL</creatorcontrib><creatorcontrib>Schmidt, L</creatorcontrib><creatorcontrib>Mathiesen, E R</creatorcontrib><creatorcontrib>Hansen, T</creatorcontrib><creatorcontrib>Jensen, D M</creatorcontrib><creatorcontrib>Holm, S</creatorcontrib><creatorcontrib>Poulsen, L</creatorcontrib><creatorcontrib>From, M</creatorcontrib><creatorcontrib>Damm, P</creatorcontrib><collection>Neurosciences Abstracts</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Clausen, T D</au><au>Mortensen, EL</au><au>Schmidt, L</au><au>Mathiesen, E R</au><au>Hansen, T</au><au>Jensen, D M</au><au>Holm, S</au><au>Poulsen, L</au><au>From, M</au><au>Damm, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive function in adult offspring of women with Type1 diabetes</atitle><jtitle>Diabetic medicine</jtitle><date>2011-07-01</date><risdate>2011</risdate><volume>28</volume><issue>7</issue><spage>838</spage><epage>844</epage><pages>838-844</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><abstract>Aims Maternal diabetes may affect offspring cognitive function. The objective of the study was to evaluate cognitive function and potential predictors hereof in adult offspring of women with Type1 diabetes. Methods We conducted a follow-up study of adult offspring of women with Type1 diabetes (n=158) and a reference group from the background population (n=118). The main outcome measure was offspring cognitive function measured by global cognitive score, derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Results Offspring of women with Type1 diabetes obtained lower global cognitive scores (94.8 vs. 100.0, P=0.004) than offspring from the background population. When adjusted for confounders, the groups no longer differed significantly (difference 0.4, 95%CI -3.3 to 4.). Positive predictors of cognitive function in offspring of women with diabetes were family social class, parental educational level, maternal diabetes duration, male gender and offspring age, whereas parity greater than or equal to 1 and gestational age <34weeks were negative predictors. We found no association with maternal glycaemia during pregnancy or with neonatal hypoglycaemia. Conclusions Impaired cognitive function in adult offspring of women with Type1 diabetes compared with the background population apparently reflects differences with respect to well-known confounders. However, harmful effects of maternal hyperglycaemia may be mediated through delivery at <34weeks.Original Abstract: Diabet. Med. 28, 838-844 (2011)</abstract><doi>10.1111/j.1464-5491.2011.03300.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0742-3071 |
| ispartof | Diabetic medicine, 2011-07, Vol.28 (7), p.838-844 |
| issn | 0742-3071 1464-5491 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1022563292 |
| source | Wiley Journals |
| subjects | Age Cognitive ability Diabetes mellitus Gestational age Intelligence Neonates Parity Pregnancy Progeny |
| title | Cognitive function in adult offspring of women with Type1 diabetes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T01%3A11%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cognitive%20function%20in%20adult%20offspring%20of%20women%20with%20Type1%20diabetes&rft.jtitle=Diabetic%20medicine&rft.au=Clausen,%20T%20D&rft.date=2011-07-01&rft.volume=28&rft.issue=7&rft.spage=838&rft.epage=844&rft.pages=838-844&rft.issn=0742-3071&rft.eissn=1464-5491&rft_id=info:doi/10.1111/j.1464-5491.2011.03300.x&rft_dat=%3Cproquest%3E1022563292%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1022563292&rft_id=info:pmid/&rfr_iscdi=true |