Cognitive function in adult offspring of women with Type1 diabetes

Aims Maternal diabetes may affect offspring cognitive function. The objective of the study was to evaluate cognitive function and potential predictors hereof in adult offspring of women with Type1 diabetes. Methods We conducted a follow-up study of adult offspring of women with Type1 diabetes (n=158) and a reference group from the background population (n=118). The main outcome measure was offspring cognitive function measured by global cognitive score, derived from Raven's Progressive Matrices and three verbal subtests from the Weschler Adult Intelligence Scale. Results Offspring of women with Type1 diabetes obtained lower global cognitive scores (94.8 vs. 100.0, P=0.004) than offspring from the background population. When adjusted for confounders, the groups no longer differed significantly (difference 0.4, 95%CI -3.3 to 4.). Positive predictors of cognitive function in offspring of women with diabetes were family social class, parental educational level, maternal diabetes duration, male gender and offspring age, whereas parity greater than or equal to 1 and gestational age