Correlation between low-level expression of the tumor suppressor gene TAp73 and the chemoresistance of human glioma stem cells

Objective Glioma stem cells (GSCs) are regarded as the root of glioma growth and recurrence. Chemoresistance is one of the characteristics of GSCs that increases the difficulties in eradicating the cells by anticancer drugs. Purpose The objective of this study is to investigate the correlation betwe...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2012-05, Vol.69 (5), p.1205-1212
Hauptverfasser:	Hu, Xiaogang, Wu, Nan, Xia, Peiyuan, Yu, Sicang, Sun, Fengjun, Chen, Jianhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Antineoplastic agents Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Apoptosis - drug effects Bax protein Biological and medical sciences Brain tumors Cancer Research Caspase-3 Chemoresistance Cisplatin Cisplatin - pharmacology DNA-Binding Proteins - genetics Drug Resistance, Neoplasm - genetics Flow Cytometry Fluorescence Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Glioblastoma - drug therapy Glioblastoma - pathology Glioma Glioma cells Humans Medical sciences Medicine Medicine & Public Health Neoplastic Stem Cells - drug effects Neurology Nuclear Proteins - genetics Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Polymerase chain reaction Proteins Reverse Transcriptase Polymerase Chain Reaction Reverse transcription RNA, Messenger - metabolism RNA, Small Interfering - metabolism Roots siRNA Stem cells Transfection Tumor Protein p73 Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumors Tumors of the nervous system. Phacomatoses Western blotting
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