An RNA Aptamer That Binds Carcinoembryonic Antigen Inhibits Hepatic Metastasis of Colon Cancer Cells in Mice

Background & Aims Carcinoembryonic antigen (CEA) is expressed by many types of cancer cells; its overexpression induces cell adhesion, increases resistance to anoikis, and promotes hepatic metastasis of colon cancer cells. The amino acid sequence PELPK in its hinge region, between the N and A1 d...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2012-07, Vol.143 (1), p.155-165.e8
Hauptverfasser:	Lee, Young Ju, Han, Seung Ryul, Kim, Nam Yeon, Lee, Soo–Han, Jeong, Jin–Sook, Lee, Seong–Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anoikis - drug effects Apoptosis Aptamers, Nucleotide - pharmacology Carcinoembryonic Antigen - metabolism Cell Adhesion - drug effects Cell Line, Tumor Colonic Neoplasms - pathology Colorectal Cancer CRC Diagnostic Agent Gastroenterology and Hepatology Liver - drug effects Liver Neoplasms - metabolism Liver Neoplasms - secondary Mice
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