miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

Background & Aims Tumor cells survive hypoxic conditions by inducing autophagy. We investigated the roles of microRNAs (miRNAs) in regulating autophagy of hepatocellular carcinoma (HCC) cells under hypoxic conditions. Methods We used gain- and loss-of-function methods to evaluate the effect of m...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2012-07, Vol.143 (1), p.177-187.e8
Hauptverfasser:	Chang, Ying, Yan, Wei, He, Xingxing, Zhang, Lemeng, Li, Chuanjiang, Huang, Hai, Nace, Gary, Geller, David A, Lin, Jusheng, Tsung, Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Autophagy-Related Protein 7 Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - physiopathology Cell Death Cell Line, Tumor Cell Survival Gastroenterology and Hepatology Gene Expression Humans Hypoxia Liver Cancer Liver Neoplasms - genetics Liver Neoplasms - physiopathology Male Mice MicroRNAs - genetics mRNA Processing Ubiquitin-Activating Enzymes - genetics
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