Association of Fcγ receptor IIIA variant with a subset of anti-topoisomerase I-positive patients in systemic sclerosis: a descriptive pilot study

Hypothesizing a pathophysiological role of anti-topoisomerase I antibodies (anti-topo I) through autoantibody-dependent cell-mediated cytotoxicity (ADCC) and cytotoxic effectors expressing receptors for the Fc portion of IgG in systemic sclerosis (SSc), 267 SSc patients (56 with anti-topo I and 102...

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Veröffentlicht in:	Rheumatology international 2012-07, Vol.32 (7), p.2203-2207
Hauptverfasser:	Magnant, J., Ohresser, M., Allanore, Y., de Monte, M., Lafosse-Marin, M., Degenne, D., Guilmot, J. L., Watier, H., Diot, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibody-Dependent Cell Cytotoxicity - immunology Autoantibodies - immunology Centromere - immunology DNA Topoisomerases, Type I - immunology Genetic Association Studies Humans Male Medicine Medicine & Public Health Middle Aged Pilot Projects Receptors, IgG - genetics Receptors, IgG - immunology Rheumatology Scleroderma, Systemic - genetics Scleroderma, Systemic - immunology Short Communication
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