Synthesis of a Heparan Sulfate Mimetic Library Targeting FGF and VEGF via Click Chemistry on a Monosaccharide Template

A disulfated methyl 6‐azido‐6‐deoxy‐α‐D‐mannopyranoside template was used as a core structure for binding to the angiogenic growth factors FGF‐1, FGF‐2, and VEGF. The core structure was diversified in a rapid, parallel manner by employing the CuI‐catalyzed Huisgen azide–alkyne cycloaddition (“click”...

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