Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

► PKM2 is associated with poor survival of gastric cancer patients. ► PKM2 affects cell survival by regulating Bcl-xL at the transcriptional level. ► PKM2 affects stabilization of p65 protein. ► PKM2/NF-κB/Bcl-xL may be a potential cascade in cancer progression. PKM2 is an isoenzyme of the glycolyti...

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Veröffentlicht in:	Biochemical and biophysical research communications 2012-06, Vol.423 (1), p.38-44
Hauptverfasser:	Kwon, Oh-Hyung, Kang, Tae-Wook, Kim, Jeong-Hwan, Kim, Mirang, Noh, Seung-Moo, Song, Kyu-Sang, Yoo, Hyang-Sook, Kim, Woo-Ho, Xie, Zhi, Pocalyko, David, Kim, Seon-Young, Kim, Yong Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	bcl-X Protein - genetics Bcl-xL Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Line, Tumor Cell Proliferation Gastric cancer Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans NF-κB PKM2 Prognosis Pyruvate Kinase - genetics Pyruvate Kinase - metabolism Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transcription Factor RelA - metabolism Transcription, Genetic
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