Prenatal retinoic acid improves lung vascularization and VEGF expression in CDH rat

Objective We sought to investigate the effects of antenatal retinoic acid on the pulmonary vasculature and vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR) expression in a nitrofen-induced congenital diaphragmatic hernia (CDH) model. Study Design Rat fetuses were exposed to nitro...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2012-07, Vol.207 (1), p.76.e25-76.e32
Hauptverfasser:	Schmidt, Augusto F., MD, PhD, Gonçalves, Frances L.L., BS, PhD, Regis, Aline C., MS, Gallindo, Rodrigo M., MD, Sbragia, Lourenço, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Angiogenesis Inducing Agents - pharmacology Angiogenesis Inducing Agents - therapeutic use Animals Arterioles - drug effects Arterioles - pathology Biomarkers - metabolism Blotting, Western congenital diaphragmatic hernia Disease Models, Animal Female fetal rat Hernia, Diaphragmatic - chemically induced Hernia, Diaphragmatic - drug therapy Hernia, Diaphragmatic - metabolism Hernia, Diaphragmatic - pathology Hernias, Diaphragmatic, Congenital Lung - blood supply Lung - drug effects Lung - embryology Lung - pathology lung morphometry Obstetrics and Gynecology Phenyl Ethers Pregnancy Rats Rats, Sprague-Dawley retinol Teratogens Treatment Outcome Tretinoin - pharmacology Tretinoin - therapeutic use vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism
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