Noninflammatory Cerebral Vasculopathy Associated with Recurrent Ischemic Strokes
Recurrent ischemic strokes often have uncommon causes in young adults. Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subse...
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| Veröffentlicht in: | Journal of stroke and cerebrovascular diseases 2012-07, Vol.21 (5), p.417-421 |
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| container_end_page | 421 |
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| container_issue | 5 |
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| container_title | Journal of stroke and cerebrovascular diseases |
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| creator | McKinney, James S., MD Raser, Jonathan M., MD, PhD Guzman, Miguel A., MD Schlaepfer, William W., MD Cucchiara, Brett L., MD Messé, Steven R., MD Sansing, Lauren H., MD Kasner, Scott E., MD, MSCE |
| description | Recurrent ischemic strokes often have uncommon causes in young adults. Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subsequent brain biopsy revealed a distinctive histopathological pattern of abnormal perivascular collagen deposition without inflammation. Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail. |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2010.09.008 |
| format | Article |
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Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subsequent brain biopsy revealed a distinctive histopathological pattern of abnormal perivascular collagen deposition without inflammation. Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2010.09.008</identifier><identifier>PMID: 21075007</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Biopsy ; Brain - blood supply ; Brain - pathology ; Brain Ischemia - diagnosis ; Brain Ischemia - etiology ; Cardiovascular ; Cerebral Angiography ; Humans ; Male ; Neurology ; perivascular ; Recurrence ; Stroke ; Stroke - diagnosis ; Stroke - etiology</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2012-07, Vol.21 (5), p.417-421</ispartof><rights>National Stroke Association</rights><rights>2012 National Stroke Association</rights><rights>Copyright © 2012 National Stroke Association. Published by Elsevier Inc. 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Vascular abnormalities may be considered as a possible etiology. We report a 36-year-old man who experienced recurrent cryptogenic ischemic strokes despite medical therapy. Conventional cerebral angiography was unrevealing. Subsequent brain biopsy revealed a distinctive histopathological pattern of abnormal perivascular collagen deposition without inflammation. Recurrent cryptogenic strokes may have novel etiologies, and brain biopsy should be considered when standard diagnostic tests fail.</description><subject>Adult</subject><subject>Biopsy</subject><subject>Brain - blood supply</subject><subject>Brain - pathology</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - etiology</subject><subject>Cardiovascular</subject><subject>Cerebral Angiography</subject><subject>Humans</subject><subject>Male</subject><subject>Neurology</subject><subject>perivascular</subject><subject>Recurrence</subject><subject>Stroke</subject><subject>Stroke - diagnosis</subject><subject>Stroke - etiology</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU9v1DAQxS0EoqXwFVCOCCnL2Ik3yQWprPhTaQWIAlfLOxlrnSbx4kmK9tvjdAsHxIWTx9JP7828J8RLCSsJcv2qW3U8xXBDSJF2Mdxabj2vFCQAmhVA_UCcS12ovNZSPkwzaJUXoKsz8YS5A5BS1_qxOFMSKg1QnYvPH8PoR9fbYbBTiMdsc6dt--y7ZZz7cLDT_phdMgf0dqI2--mnffaFcI6Rxim7YtzT4DG7vluNn4pHzvZMz-7fC_Ht3duvmw_59tP7q83lNsdSN1MuC6irqnRYIaCyy0_vSgdNVZKyGteuKDXUDSkiVeK6da6pHaYbSUpX18WFeHHSPcTwYyaezOAZqe_tSGFmI0EppSsFVULfnFCMgTmSM4foBxuPCTJLsqYz_0rWLMkaaExyTSLP7_3m3UDtH4nfUSZgewIoXX3rKRpGTyNS6yPhZNrg_8_v9V9y2PvRo-1v6EjchTmOKV8jDSsD5nrpeqlaQqq5keviF36Grhk</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>McKinney, James S., MD</creator><creator>Raser, Jonathan M., MD, PhD</creator><creator>Guzman, Miguel A., MD</creator><creator>Schlaepfer, William W., MD</creator><creator>Cucchiara, Brett L., MD</creator><creator>Messé, Steven R., MD</creator><creator>Sansing, Lauren H., MD</creator><creator>Kasner, Scott E., MD, MSCE</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Noninflammatory Cerebral Vasculopathy Associated with Recurrent Ischemic Strokes</title><author>McKinney, James S., MD ; Raser, Jonathan M., MD, PhD ; Guzman, Miguel A., MD ; Schlaepfer, William W., MD ; Cucchiara, Brett L., MD ; Messé, Steven R., MD ; Sansing, Lauren H., MD ; Kasner, Scott E., MD, MSCE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-1308774fc7c0c2a30875b4f0974e2a5c6f345089e2ee24c6dff98fc008e11f883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biopsy</topic><topic>Brain - blood supply</topic><topic>Brain - pathology</topic><topic>Brain Ischemia - diagnosis</topic><topic>Brain Ischemia - etiology</topic><topic>Cardiovascular</topic><topic>Cerebral Angiography</topic><topic>Humans</topic><topic>Male</topic><topic>Neurology</topic><topic>perivascular</topic><topic>Recurrence</topic><topic>Stroke</topic><topic>Stroke - diagnosis</topic><topic>Stroke - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McKinney, James S., MD</creatorcontrib><creatorcontrib>Raser, Jonathan M., MD, PhD</creatorcontrib><creatorcontrib>Guzman, Miguel A., MD</creatorcontrib><creatorcontrib>Schlaepfer, William W., MD</creatorcontrib><creatorcontrib>Cucchiara, Brett L., MD</creatorcontrib><creatorcontrib>Messé, Steven R., MD</creatorcontrib><creatorcontrib>Sansing, Lauren H., MD</creatorcontrib><creatorcontrib>Kasner, Scott E., MD, MSCE</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McKinney, James S., MD</au><au>Raser, Jonathan M., MD, PhD</au><au>Guzman, Miguel A., MD</au><au>Schlaepfer, William W., MD</au><au>Cucchiara, Brett L., MD</au><au>Messé, Steven R., MD</au><au>Sansing, Lauren H., MD</au><au>Kasner, Scott E., MD, MSCE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninflammatory Cerebral Vasculopathy Associated with Recurrent Ischemic Strokes</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>21</volume><issue>5</issue><spage>417</spage><epage>421</epage><pages>417-421</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>Recurrent ischemic strokes often have uncommon causes in young adults. 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| identifier | ISSN: 1052-3057 |
| ispartof | Journal of stroke and cerebrovascular diseases, 2012-07, Vol.21 (5), p.417-421 |
| issn | 1052-3057 1532-8511 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Biopsy Brain - blood supply Brain - pathology Brain Ischemia - diagnosis Brain Ischemia - etiology Cardiovascular Cerebral Angiography Humans Male Neurology perivascular Recurrence Stroke Stroke - diagnosis Stroke - etiology |
| title | Noninflammatory Cerebral Vasculopathy Associated with Recurrent Ischemic Strokes |
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