Inorganic phosphate and FGF-23 predict outcome in stable systolic heart failure
Eur J Clin Invest 2012; 42 (6): 649–656 Background Recent studies show associations between inorganic phosphate and risk of heart failure in the general population as well as between fibroblast growth factor 23 (FGF‐23) and outcome in coronary heart disease. This study was carried out to assess whe...
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| creator | Plischke, Max Neuhold, Stephanie Adlbrecht, Christopher Bielesz, Bernhard Shayganfar, Sascha Bieglmayer, Christian Szekeres, Thomas Hörl, Walter H. Strunk, Guido Vavken, Patrick Pacher, Richard Hülsmann, Martin |
| description | Eur J Clin Invest 2012; 42 (6): 649–656
Background Recent studies show associations between inorganic phosphate and risk of heart failure in the general population as well as between fibroblast growth factor 23 (FGF‐23) and outcome in coronary heart disease. This study was carried out to assess whether circulating levels of inorganic phosphate and FGF‐23, a new central hormone in mineral bone metabolism, predict outcome in systolic heart failure.
Materials and methods Ninety‐nine consecutive outpatients with systolic heart failure were enrolled. Mean (SD) age was 61 years (11), mean left ventricular ejection fraction (LVEF) was 33% (10), 82 patients were men, median estimated creatinine clearance was 83 mL/min (Q1–Q3 58–106), median NTproBNP level was 803 pg/mL (Q1–Q3 404–2757), median inorganic phosphate was 1·12 mM (Q1–Q3 1·02–1·22), median FGF‐23 was 39·02 pg/mL (Q1–Q3 32·45–55·86) and median follow‐up was 35 months. Associations between inorganic phosphate, FGF‐23 and endpoints were assessed using Cox regression analyses.
Results Inorganic phosphate and FGF‐23 levels were significantly higher (P |
| doi_str_mv | 10.1111/j.1365-2362.2011.02631.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1022256842</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1022256842</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5031-f35965c83501a3dbdd68cedc4cef4d43e6f525f38ae25942f773ee44090598ec3</originalsourceid><addsrcrecordid>eNqNkF1v0zAUhi3ExLrBX0C-QeImwT6283HBBarWrtLYhPi6tFznmKakSbAT0f77OWtXbvGNLfl53nP0EkI5S3k8H7YpF5lKQGSQAuM8ZZAJnu5fkNn54yWZMcZlAmUOl-QqhC1jrOACXpFLAK4YBzEjD6u2879MW1vab7rQb8yA1LQVXSwXMYb2HqvaDrQbB9vtkNYtDYNZN0jDIQxdE70NGj9QZ-pm9PiaXDjTBHxzuq_J98XNt_ltcvewXM0_3SVWMcETJ1SZKVuIuIYR1bqqssJiZaVFJyspMHMKlBOFQVClBJfnAlFKVjJVFmjFNXl_zO1992fEMOhdHSw2jWmxG4PmDABUVkiIaHFEre9C8Oh07-ud8YcI6alOvdVTa3pqTU916qc69T6qb09TxvUOq7P43F8E3p0AE6xpnDetrcM_TpUcGOSR-3jk_tYNHv57AX0zX02v6CdHvw4D7s--8b91lotc6Z_3Sz2___L5x9eYKcUjrnSeIw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1022256842</pqid></control><display><type>article</type><title>Inorganic phosphate and FGF-23 predict outcome in stable systolic heart failure</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Plischke, Max ; Neuhold, Stephanie ; Adlbrecht, Christopher ; Bielesz, Bernhard ; Shayganfar, Sascha ; Bieglmayer, Christian ; Szekeres, Thomas ; Hörl, Walter H. ; Strunk, Guido ; Vavken, Patrick ; Pacher, Richard ; Hülsmann, Martin</creator><creatorcontrib>Plischke, Max ; Neuhold, Stephanie ; Adlbrecht, Christopher ; Bielesz, Bernhard ; Shayganfar, Sascha ; Bieglmayer, Christian ; Szekeres, Thomas ; Hörl, Walter H. ; Strunk, Guido ; Vavken, Patrick ; Pacher, Richard ; Hülsmann, Martin</creatorcontrib><description>Eur J Clin Invest 2012; 42 (6): 649–656
Background Recent studies show associations between inorganic phosphate and risk of heart failure in the general population as well as between fibroblast growth factor 23 (FGF‐23) and outcome in coronary heart disease. This study was carried out to assess whether circulating levels of inorganic phosphate and FGF‐23, a new central hormone in mineral bone metabolism, predict outcome in systolic heart failure.
Materials and methods Ninety‐nine consecutive outpatients with systolic heart failure were enrolled. Mean (SD) age was 61 years (11), mean left ventricular ejection fraction (LVEF) was 33% (10), 82 patients were men, median estimated creatinine clearance was 83 mL/min (Q1–Q3 58–106), median NTproBNP level was 803 pg/mL (Q1–Q3 404–2757), median inorganic phosphate was 1·12 mM (Q1–Q3 1·02–1·22), median FGF‐23 was 39·02 pg/mL (Q1–Q3 32·45–55·86) and median follow‐up was 35 months. Associations between inorganic phosphate, FGF‐23 and endpoints were assessed using Cox regression analyses.
Results Inorganic phosphate and FGF‐23 levels were significantly higher (P < 0·001 and P = 0·009) in patients reaching the combined endpoint of cardiac hospitalization or death. FGF‐23 (ln) predicted all‐cause mortality (hazard ratio (HR) 5·042, P = 0·032) in a model adjusted for age, gender, estimated creatinine clearance, LVEF, New York Heart Association (NYHA) stage and NTproBNP level. Inorganic phosphate predicted heart failure hospitalization (HR 26·944, P = 0·021), cardiac hospitalization (HR 16·016, P = 0·017) and the combined endpoint (HR 13·294, P = 0·015) in models adjusted for the same co‐variables.
Conclusion The results of this study demonstrate the independent prognostic value of inorganic phosphate and FGF‐23 in heart failure even in the context of established risk markers.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/j.1365-2362.2011.02631.x</identifier><identifier>PMID: 22150123</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biological and medical sciences ; Cardiology. Vascular system ; Cohort Studies ; Epidemiology ; Female ; FGF-23 ; Fibroblast Growth Factors - blood ; General aspects ; Heart ; heart failure ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Heart Failure, Systolic - blood ; Heart Failure, Systolic - mortality ; Hospitalization ; Humans ; Male ; Medical sciences ; Middle Aged ; mortality ; phosphates ; Phosphates - blood ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Regression Analysis ; rehospitalization ; Risk Assessment ; Risk Factors</subject><ispartof>European journal of clinical investigation, 2012-06, Vol.42 (6), p.649-656</ispartof><rights>2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5031-f35965c83501a3dbdd68cedc4cef4d43e6f525f38ae25942f773ee44090598ec3</citedby><cites>FETCH-LOGICAL-c5031-f35965c83501a3dbdd68cedc4cef4d43e6f525f38ae25942f773ee44090598ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2362.2011.02631.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2362.2011.02631.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25912027$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22150123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plischke, Max</creatorcontrib><creatorcontrib>Neuhold, Stephanie</creatorcontrib><creatorcontrib>Adlbrecht, Christopher</creatorcontrib><creatorcontrib>Bielesz, Bernhard</creatorcontrib><creatorcontrib>Shayganfar, Sascha</creatorcontrib><creatorcontrib>Bieglmayer, Christian</creatorcontrib><creatorcontrib>Szekeres, Thomas</creatorcontrib><creatorcontrib>Hörl, Walter H.</creatorcontrib><creatorcontrib>Strunk, Guido</creatorcontrib><creatorcontrib>Vavken, Patrick</creatorcontrib><creatorcontrib>Pacher, Richard</creatorcontrib><creatorcontrib>Hülsmann, Martin</creatorcontrib><title>Inorganic phosphate and FGF-23 predict outcome in stable systolic heart failure</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Eur J Clin Invest 2012; 42 (6): 649–656
Background Recent studies show associations between inorganic phosphate and risk of heart failure in the general population as well as between fibroblast growth factor 23 (FGF‐23) and outcome in coronary heart disease. This study was carried out to assess whether circulating levels of inorganic phosphate and FGF‐23, a new central hormone in mineral bone metabolism, predict outcome in systolic heart failure.
Materials and methods Ninety‐nine consecutive outpatients with systolic heart failure were enrolled. Mean (SD) age was 61 years (11), mean left ventricular ejection fraction (LVEF) was 33% (10), 82 patients were men, median estimated creatinine clearance was 83 mL/min (Q1–Q3 58–106), median NTproBNP level was 803 pg/mL (Q1–Q3 404–2757), median inorganic phosphate was 1·12 mM (Q1–Q3 1·02–1·22), median FGF‐23 was 39·02 pg/mL (Q1–Q3 32·45–55·86) and median follow‐up was 35 months. Associations between inorganic phosphate, FGF‐23 and endpoints were assessed using Cox regression analyses.
Results Inorganic phosphate and FGF‐23 levels were significantly higher (P < 0·001 and P = 0·009) in patients reaching the combined endpoint of cardiac hospitalization or death. FGF‐23 (ln) predicted all‐cause mortality (hazard ratio (HR) 5·042, P = 0·032) in a model adjusted for age, gender, estimated creatinine clearance, LVEF, New York Heart Association (NYHA) stage and NTproBNP level. Inorganic phosphate predicted heart failure hospitalization (HR 26·944, P = 0·021), cardiac hospitalization (HR 16·016, P = 0·017) and the combined endpoint (HR 13·294, P = 0·015) in models adjusted for the same co‐variables.
Conclusion The results of this study demonstrate the independent prognostic value of inorganic phosphate and FGF‐23 in heart failure even in the context of established risk markers.</description><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>FGF-23</subject><subject>Fibroblast Growth Factors - blood</subject><subject>General aspects</subject><subject>Heart</subject><subject>heart failure</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Heart Failure, Systolic - blood</subject><subject>Heart Failure, Systolic - mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mortality</subject><subject>phosphates</subject><subject>Phosphates - blood</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Regression Analysis</subject><subject>rehospitalization</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v0zAUhi3ExLrBX0C-QeImwT6283HBBarWrtLYhPi6tFznmKakSbAT0f77OWtXbvGNLfl53nP0EkI5S3k8H7YpF5lKQGSQAuM8ZZAJnu5fkNn54yWZMcZlAmUOl-QqhC1jrOACXpFLAK4YBzEjD6u2879MW1vab7rQb8yA1LQVXSwXMYb2HqvaDrQbB9vtkNYtDYNZN0jDIQxdE70NGj9QZ-pm9PiaXDjTBHxzuq_J98XNt_ltcvewXM0_3SVWMcETJ1SZKVuIuIYR1bqqssJiZaVFJyspMHMKlBOFQVClBJfnAlFKVjJVFmjFNXl_zO1992fEMOhdHSw2jWmxG4PmDABUVkiIaHFEre9C8Oh07-ud8YcI6alOvdVTa3pqTU916qc69T6qb09TxvUOq7P43F8E3p0AE6xpnDetrcM_TpUcGOSR-3jk_tYNHv57AX0zX02v6CdHvw4D7s--8b91lotc6Z_3Sz2___L5x9eYKcUjrnSeIw</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Plischke, Max</creator><creator>Neuhold, Stephanie</creator><creator>Adlbrecht, Christopher</creator><creator>Bielesz, Bernhard</creator><creator>Shayganfar, Sascha</creator><creator>Bieglmayer, Christian</creator><creator>Szekeres, Thomas</creator><creator>Hörl, Walter H.</creator><creator>Strunk, Guido</creator><creator>Vavken, Patrick</creator><creator>Pacher, Richard</creator><creator>Hülsmann, Martin</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Inorganic phosphate and FGF-23 predict outcome in stable systolic heart failure</title><author>Plischke, Max ; Neuhold, Stephanie ; Adlbrecht, Christopher ; Bielesz, Bernhard ; Shayganfar, Sascha ; Bieglmayer, Christian ; Szekeres, Thomas ; Hörl, Walter H. ; Strunk, Guido ; Vavken, Patrick ; Pacher, Richard ; Hülsmann, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5031-f35965c83501a3dbdd68cedc4cef4d43e6f525f38ae25942f773ee44090598ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cohort Studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>FGF-23</topic><topic>Fibroblast Growth Factors - blood</topic><topic>General aspects</topic><topic>Heart</topic><topic>heart failure</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Heart Failure, Systolic - blood</topic><topic>Heart Failure, Systolic - mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mortality</topic><topic>phosphates</topic><topic>Phosphates - blood</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Regression Analysis</topic><topic>rehospitalization</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plischke, Max</creatorcontrib><creatorcontrib>Neuhold, Stephanie</creatorcontrib><creatorcontrib>Adlbrecht, Christopher</creatorcontrib><creatorcontrib>Bielesz, Bernhard</creatorcontrib><creatorcontrib>Shayganfar, Sascha</creatorcontrib><creatorcontrib>Bieglmayer, Christian</creatorcontrib><creatorcontrib>Szekeres, Thomas</creatorcontrib><creatorcontrib>Hörl, Walter H.</creatorcontrib><creatorcontrib>Strunk, Guido</creatorcontrib><creatorcontrib>Vavken, Patrick</creatorcontrib><creatorcontrib>Pacher, Richard</creatorcontrib><creatorcontrib>Hülsmann, Martin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plischke, Max</au><au>Neuhold, Stephanie</au><au>Adlbrecht, Christopher</au><au>Bielesz, Bernhard</au><au>Shayganfar, Sascha</au><au>Bieglmayer, Christian</au><au>Szekeres, Thomas</au><au>Hörl, Walter H.</au><au>Strunk, Guido</au><au>Vavken, Patrick</au><au>Pacher, Richard</au><au>Hülsmann, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inorganic phosphate and FGF-23 predict outcome in stable systolic heart failure</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2012-06</date><risdate>2012</risdate><volume>42</volume><issue>6</issue><spage>649</spage><epage>656</epage><pages>649-656</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Eur J Clin Invest 2012; 42 (6): 649–656
Background Recent studies show associations between inorganic phosphate and risk of heart failure in the general population as well as between fibroblast growth factor 23 (FGF‐23) and outcome in coronary heart disease. This study was carried out to assess whether circulating levels of inorganic phosphate and FGF‐23, a new central hormone in mineral bone metabolism, predict outcome in systolic heart failure.
Materials and methods Ninety‐nine consecutive outpatients with systolic heart failure were enrolled. Mean (SD) age was 61 years (11), mean left ventricular ejection fraction (LVEF) was 33% (10), 82 patients were men, median estimated creatinine clearance was 83 mL/min (Q1–Q3 58–106), median NTproBNP level was 803 pg/mL (Q1–Q3 404–2757), median inorganic phosphate was 1·12 mM (Q1–Q3 1·02–1·22), median FGF‐23 was 39·02 pg/mL (Q1–Q3 32·45–55·86) and median follow‐up was 35 months. Associations between inorganic phosphate, FGF‐23 and endpoints were assessed using Cox regression analyses.
Results Inorganic phosphate and FGF‐23 levels were significantly higher (P < 0·001 and P = 0·009) in patients reaching the combined endpoint of cardiac hospitalization or death. FGF‐23 (ln) predicted all‐cause mortality (hazard ratio (HR) 5·042, P = 0·032) in a model adjusted for age, gender, estimated creatinine clearance, LVEF, New York Heart Association (NYHA) stage and NTproBNP level. Inorganic phosphate predicted heart failure hospitalization (HR 26·944, P = 0·021), cardiac hospitalization (HR 16·016, P = 0·017) and the combined endpoint (HR 13·294, P = 0·015) in models adjusted for the same co‐variables.
Conclusion The results of this study demonstrate the independent prognostic value of inorganic phosphate and FGF‐23 in heart failure even in the context of established risk markers.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22150123</pmid><doi>10.1111/j.1365-2362.2011.02631.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Biological and medical sciences Cardiology. Vascular system Cohort Studies Epidemiology Female FGF-23 Fibroblast Growth Factors - blood General aspects Heart heart failure Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Failure, Systolic - blood Heart Failure, Systolic - mortality Hospitalization Humans Male Medical sciences Middle Aged mortality phosphates Phosphates - blood Predictive Value of Tests Prognosis Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Regression Analysis rehospitalization Risk Assessment Risk Factors |
| title | Inorganic phosphate and FGF-23 predict outcome in stable systolic heart failure |
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