Synthetic approaches to a chiral 4-amino-3-hydroxy piperidine with pharmaceutical relevance

Four synthetic strategies were evaluated towards the preparation of (-)-(3R,4R)-1-benzyl-4-(benzylamino)piperidin-3-ol (1), which was constructed with control over the relative and absolute stereochemistry of the 4,3-amino alcohol moiety. The first strategy employed a novel Rh(I) catalyzed asymmetri...

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Veröffentlicht in:	Organic & biomolecular chemistry 2012-07, Vol.10 (27), p.5253-5257
Hauptverfasser:	Ortiz, Adrian, Young, Ian S, Sawyer, James R, Hsiao, Yi, Singh, Amarjit, Sugiyama, Masano, Corbett, R Michael, Chau, Melissa, Shi, Zhongping, Conlon, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	Hydrogenation Models, Molecular Molecular Structure Piperidines - chemical synthesis Stereoisomerism
Online-Zugang:	Volltext
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