Comparative characterization of skin lesions observed in the three endemic varieties of cutaneous leishmaniasis in Tunisia
The recent spread in the geographical distribution of the three forms of cutaneous leishmaniasis (CL) endemic in Tunisia has resulted in the coexistence of more than one species of Leishmania (L.) in some foci, rendering characterization on the basis of geographical criteria alone more difficult. Th...
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| Veröffentlicht in: | Annales de dermatologie et de vénéréologie 2012-06, Vol.139 (6-7), p.452-458 |
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| creator | Aoun, K Ben Abda, I Bousslimi, N Bettaieb, J Siala, E Ben Abdallah, R Benmously, R Bouratbine, A |
| description | The recent spread in the geographical distribution of the three forms of cutaneous leishmaniasis (CL) endemic in Tunisia has resulted in the coexistence of more than one species of Leishmania (L.) in some foci, rendering characterization on the basis of geographical criteria alone more difficult. The aim of the study was to establish clinical criteria associated with these noso-geographic forms, namely sporadic CL (SCL) due to L. infantum, zoonotic CL (ZCL) due to L. major and chronic CL (CCL) due to L. tropica.
One hundred and twelve patients with biologically confirmed CL were involved in the study. Leishmania species was systematically identified by iso-enzyme analysis and/or PCR-RFLP. Details of the number, the location, the morphological aspect and the month of outbreak of the lesions were noted for each patient.
SCL lesions appeared later than ZCL lesions (53.8% of cases appeared from December onwards vs. 23.6%, P |
| doi_str_mv | 10.1016/j.annder.2012.04.154 |
| format | Article |
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One hundred and twelve patients with biologically confirmed CL were involved in the study. Leishmania species was systematically identified by iso-enzyme analysis and/or PCR-RFLP. Details of the number, the location, the morphological aspect and the month of outbreak of the lesions were noted for each patient.
SCL lesions appeared later than ZCL lesions (53.8% of cases appeared from December onwards vs. 23.6%, P<0.001). ZCL lesions were often multiple (75%) and situated on the limbs (84.7%, P<0.001), whereas SCL lesions were single (92.3%, P<0.001) and located on the face (84.6%, P<0.001). CCL lesions were also single (78.6%) and located on the face (71.4%). The classical ulcerous presentation with scabs was mainly observed in ZCL patients (69.4%) and the erythematous presentation was described more frequently in SCL patients (75%; P<0.001).
The number, site, morphological aspect and month of outbreak of lesions could be considered as useful criteria that help differentiate between the three noso-geographical forms of CL prevailing in Tunisia. Such characterization is useful for the individual management of patients and for optimizing the combat against the disease.</description><identifier>ISSN: 0151-9638</identifier><identifier>DOI: 10.1016/j.annder.2012.04.154</identifier><identifier>PMID: 22721477</identifier><language>fre</language><publisher>France</publisher><subject>Adult ; Animals ; Cross-Sectional Studies ; Endemic Diseases ; Female ; Humans ; Leishmania infantum ; Leishmania major ; Leishmania tropica ; Leishmaniasis, Cutaneous - diagnosis ; Leishmaniasis, Cutaneous - epidemiology ; Leishmaniasis, Cutaneous - parasitology ; Leishmaniasis, Cutaneous - pathology ; Male ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Prospective Studies ; Seasons ; Skin - parasitology ; Skin - pathology ; Tunisia ; Zoonoses</subject><ispartof>Annales de dermatologie et de vénéréologie, 2012-06, Vol.139 (6-7), p.452-458</ispartof><rights>Copyright © 2012 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22721477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoun, K</creatorcontrib><creatorcontrib>Ben Abda, I</creatorcontrib><creatorcontrib>Bousslimi, N</creatorcontrib><creatorcontrib>Bettaieb, J</creatorcontrib><creatorcontrib>Siala, E</creatorcontrib><creatorcontrib>Ben Abdallah, R</creatorcontrib><creatorcontrib>Benmously, R</creatorcontrib><creatorcontrib>Bouratbine, A</creatorcontrib><title>Comparative characterization of skin lesions observed in the three endemic varieties of cutaneous leishmaniasis in Tunisia</title><title>Annales de dermatologie et de vénéréologie</title><addtitle>Ann Dermatol Venereol</addtitle><description>The recent spread in the geographical distribution of the three forms of cutaneous leishmaniasis (CL) endemic in Tunisia has resulted in the coexistence of more than one species of Leishmania (L.) in some foci, rendering characterization on the basis of geographical criteria alone more difficult. The aim of the study was to establish clinical criteria associated with these noso-geographic forms, namely sporadic CL (SCL) due to L. infantum, zoonotic CL (ZCL) due to L. major and chronic CL (CCL) due to L. tropica.
One hundred and twelve patients with biologically confirmed CL were involved in the study. Leishmania species was systematically identified by iso-enzyme analysis and/or PCR-RFLP. Details of the number, the location, the morphological aspect and the month of outbreak of the lesions were noted for each patient.
SCL lesions appeared later than ZCL lesions (53.8% of cases appeared from December onwards vs. 23.6%, P<0.001). ZCL lesions were often multiple (75%) and situated on the limbs (84.7%, P<0.001), whereas SCL lesions were single (92.3%, P<0.001) and located on the face (84.6%, P<0.001). CCL lesions were also single (78.6%) and located on the face (71.4%). The classical ulcerous presentation with scabs was mainly observed in ZCL patients (69.4%) and the erythematous presentation was described more frequently in SCL patients (75%; P<0.001).
The number, site, morphological aspect and month of outbreak of lesions could be considered as useful criteria that help differentiate between the three noso-geographical forms of CL prevailing in Tunisia. Such characterization is useful for the individual management of patients and for optimizing the combat against the disease.</description><subject>Adult</subject><subject>Animals</subject><subject>Cross-Sectional Studies</subject><subject>Endemic Diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Leishmania infantum</subject><subject>Leishmania major</subject><subject>Leishmania tropica</subject><subject>Leishmaniasis, Cutaneous - diagnosis</subject><subject>Leishmaniasis, Cutaneous - epidemiology</subject><subject>Leishmaniasis, Cutaneous - parasitology</subject><subject>Leishmaniasis, Cutaneous - pathology</subject><subject>Male</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prospective Studies</subject><subject>Seasons</subject><subject>Skin - parasitology</subject><subject>Skin - pathology</subject><subject>Tunisia</subject><subject>Zoonoses</subject><issn>0151-9638</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UE1PwzAMzQHExuAfIJQjl5Y4Sdv0iCa-pElcxrlKU0fL6BdJOwl-PZk2Dpbt5_eeLRNyBywFBvnjPtV936BPOQOeMplCJi_IkkEGSZkLtSDXIexZHCqRXZEF5wUHWRRL8rseulF7PbkDUrOLlZnQu98IDD0dLA1frqcthtgGOtQB_QEbGrFphzE8IsW4unOGHrR3ODkMR52ZJ93jMIcodmHX6d7p4MJRuZ17F5y-IZdWtwFvz3lFPl-et-u3ZPPx-r5-2iQjSJiSWjW6RFOXpZVGl7VAI6WSWV4qUMByKyUvhWysAMsyDbUqmLS1ttzonAkmVuTh5Dv64XvGMFWdCwbb9nRfBYxDqUQuIVLvz9S57rCpRu867X-q_3-JP7BCb5M</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Aoun, K</creator><creator>Ben Abda, I</creator><creator>Bousslimi, N</creator><creator>Bettaieb, J</creator><creator>Siala, E</creator><creator>Ben Abdallah, R</creator><creator>Benmously, R</creator><creator>Bouratbine, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201206</creationdate><title>Comparative characterization of skin lesions observed in the three endemic varieties of cutaneous leishmaniasis in Tunisia</title><author>Aoun, K ; Ben Abda, I ; Bousslimi, N ; Bettaieb, J ; Siala, E ; Ben Abdallah, R ; Benmously, R ; Bouratbine, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-b8da9ecb99f4ca9b3ec4484569818106f442934df31f05a1b8704fbaf2ca60303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Cross-Sectional Studies</topic><topic>Endemic Diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Leishmania infantum</topic><topic>Leishmania major</topic><topic>Leishmania tropica</topic><topic>Leishmaniasis, Cutaneous - diagnosis</topic><topic>Leishmaniasis, Cutaneous - epidemiology</topic><topic>Leishmaniasis, Cutaneous - parasitology</topic><topic>Leishmaniasis, Cutaneous - pathology</topic><topic>Male</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Prospective Studies</topic><topic>Seasons</topic><topic>Skin - parasitology</topic><topic>Skin - pathology</topic><topic>Tunisia</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoun, K</creatorcontrib><creatorcontrib>Ben Abda, I</creatorcontrib><creatorcontrib>Bousslimi, N</creatorcontrib><creatorcontrib>Bettaieb, J</creatorcontrib><creatorcontrib>Siala, E</creatorcontrib><creatorcontrib>Ben Abdallah, R</creatorcontrib><creatorcontrib>Benmously, R</creatorcontrib><creatorcontrib>Bouratbine, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annales de dermatologie et de vénéréologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoun, K</au><au>Ben Abda, I</au><au>Bousslimi, N</au><au>Bettaieb, J</au><au>Siala, E</au><au>Ben Abdallah, R</au><au>Benmously, R</au><au>Bouratbine, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative characterization of skin lesions observed in the three endemic varieties of cutaneous leishmaniasis in Tunisia</atitle><jtitle>Annales de dermatologie et de vénéréologie</jtitle><addtitle>Ann Dermatol Venereol</addtitle><date>2012-06</date><risdate>2012</risdate><volume>139</volume><issue>6-7</issue><spage>452</spage><epage>458</epage><pages>452-458</pages><issn>0151-9638</issn><abstract>The recent spread in the geographical distribution of the three forms of cutaneous leishmaniasis (CL) endemic in Tunisia has resulted in the coexistence of more than one species of Leishmania (L.) in some foci, rendering characterization on the basis of geographical criteria alone more difficult. The aim of the study was to establish clinical criteria associated with these noso-geographic forms, namely sporadic CL (SCL) due to L. infantum, zoonotic CL (ZCL) due to L. major and chronic CL (CCL) due to L. tropica.
One hundred and twelve patients with biologically confirmed CL were involved in the study. Leishmania species was systematically identified by iso-enzyme analysis and/or PCR-RFLP. Details of the number, the location, the morphological aspect and the month of outbreak of the lesions were noted for each patient.
SCL lesions appeared later than ZCL lesions (53.8% of cases appeared from December onwards vs. 23.6%, P<0.001). ZCL lesions were often multiple (75%) and situated on the limbs (84.7%, P<0.001), whereas SCL lesions were single (92.3%, P<0.001) and located on the face (84.6%, P<0.001). CCL lesions were also single (78.6%) and located on the face (71.4%). The classical ulcerous presentation with scabs was mainly observed in ZCL patients (69.4%) and the erythematous presentation was described more frequently in SCL patients (75%; P<0.001).
The number, site, morphological aspect and month of outbreak of lesions could be considered as useful criteria that help differentiate between the three noso-geographical forms of CL prevailing in Tunisia. Such characterization is useful for the individual management of patients and for optimizing the combat against the disease.</abstract><cop>France</cop><pmid>22721477</pmid><doi>10.1016/j.annder.2012.04.154</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Animals Cross-Sectional Studies Endemic Diseases Female Humans Leishmania infantum Leishmania major Leishmania tropica Leishmaniasis, Cutaneous - diagnosis Leishmaniasis, Cutaneous - epidemiology Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology Male Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Prospective Studies Seasons Skin - parasitology Skin - pathology Tunisia Zoonoses |
| title | Comparative characterization of skin lesions observed in the three endemic varieties of cutaneous leishmaniasis in Tunisia |
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