HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis

Reactive oxygen species (ROS) participate in atherogenesis through different mechanisms including oxidative stress and inflammation. Proteins implicated in both processes, such as mitogen-activated protein kinase kinase (MEK) and some NADPH oxidase (NOX) subunits, are heat shock protein-90 (HSP90) c...

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Veröffentlicht in:	Cardiovascular research 2012-07, Vol.95 (1), p.116-123
Hauptverfasser:	MADRIGAL-MATUTE, Julio, FERNANDEZ-GARCIA, Carlos Ernesto, GOMEZ-GUERRERO, Carmen, LOPEZ-FRANCO, Oscar, MUNOZ-GARCIA, Begona, EGIDO, Jesus, MIGUEL BLANCO-COLIO, Luis, MARTIN-VENTURA, Jose Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis (general aspects, experimental research) Atherosclerosis - metabolism Benzoquinones - pharmacology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Differentiation Extracellular Signal-Regulated MAP Kinases - metabolism HSP90 Heat-Shock Proteins - antagonists & inhibitors Lactams, Macrocyclic - pharmacology Macrophages - cytology Male Medical sciences Mice Muscle, Smooth, Vascular - drug effects NADPH Oxidases - metabolism Oxidative Stress - drug effects Rats Rats, Wistar Reactive Oxygen Species - metabolism
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