An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry

Background:Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin. The goal was to develop an improved liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for this aim...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2012-03, Vol.50 (3), p.521-524
Hauptverfasser:	Kirchhoff, Fabian, Maier, Barbara, Rieger, Christina, Ostermann, Helmut, Spöhrer, Ute, Vogeser, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Chemical Analysis - methods caspofungin Chromatography, Liquid - methods Echinocandins - blood Echinocandins - isolation & purification General aspects Humans Investigative techniques, diagnostic techniques (general aspects) Lipopeptides liquid chromatography-tandem mass spectrometry (LC-MS/MS) Medical sciences on-line solid phase extraction (SPE) Online Systems Reproducibility of Results Solid Phase Extraction - instrumentation Solid Phase Extraction - methods Tandem Mass Spectrometry - methods tylosin
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