Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study
Periconceptional folate is essential for proper neurodevelopment. Maternal folic acid intake was examined in relation to the risk of autism spectrum disorder (ASD) and developmental delay (DD). Families enrolled in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study from 2003 to...
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| Veröffentlicht in: | The American journal of clinical nutrition 2012-07, Vol.96 (1), p.80-89 |
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| creator | SCHMIDT, Rebecca J TANCREDI, Daniel J OZONOFF, Sally HANSEN, Robin L HARTIALA, Jaana ALLAYEE, Hooman SCHMIDT, Linda C TASSONE, Flora HERTZ-PICCIOTTO, Irva |
| description | Periconceptional folate is essential for proper neurodevelopment.
Maternal folic acid intake was examined in relation to the risk of autism spectrum disorder (ASD) and developmental delay (DD).
Families enrolled in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study from 2003 to 2009 were included if their child had a diagnosis of ASD (n = 429), DD (n = 130), or typical development (TD; n = 278) confirmed at the University of California Davis Medical Investigation of Neurodevelopmental Disorders Institute by using standardized clinical assessments. Average daily folic acid was quantified for each mother on the basis of dose, brands, and intake frequency of vitamins, supplements, and breakfast cereals reported through structured telephone interviews.
Mean (±SEM) folic acid intake was significantly greater for mothers of TD children than for mothers of children with ASD in the first month of pregnancy (P1; 779.0 ± 36.1 and 655.0 ± 28.7 μg, respectively; P < 0.01). A mean daily folic acid intake of ≥600 μg (compared with T variant genotypes. A trend toward an association between lower maternal folic acid intake during the 3 mo before pregnancy and DD was observed, but not after adjustment for confounders.
Periconceptional folic acid may reduce ASD risk in those with inefficient folate metabolism. The replication of these findings and investigations of mechanisms involved are warranted. |
| doi_str_mv | 10.3945/ajcn.110.004416 |
| format | Article |
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Maternal folic acid intake was examined in relation to the risk of autism spectrum disorder (ASD) and developmental delay (DD).
Families enrolled in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study from 2003 to 2009 were included if their child had a diagnosis of ASD (n = 429), DD (n = 130), or typical development (TD; n = 278) confirmed at the University of California Davis Medical Investigation of Neurodevelopmental Disorders Institute by using standardized clinical assessments. Average daily folic acid was quantified for each mother on the basis of dose, brands, and intake frequency of vitamins, supplements, and breakfast cereals reported through structured telephone interviews.
Mean (±SEM) folic acid intake was significantly greater for mothers of TD children than for mothers of children with ASD in the first month of pregnancy (P1; 779.0 ± 36.1 and 655.0 ± 28.7 μg, respectively; P < 0.01). A mean daily folic acid intake of ≥600 μg (compared with <600 μg) during P1 was associated with reduced ASD risk (adjusted OR: 0.62; 95% CI: 0.42, 0.92; P = 0.02), and risk estimates decreased with increased folic acid (P-trend = 0.001). The association between folic acid and reduced ASD risk was strongest for mothers and children with MTHFR 677 C>T variant genotypes. A trend toward an association between lower maternal folic acid intake during the 3 mo before pregnancy and DD was observed, but not after adjustment for confounders.
Periconceptional folic acid may reduce ASD risk in those with inefficient folate metabolism. The replication of these findings and investigations of mechanisms involved are warranted.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.110.004416</identifier><identifier>PMID: 22648721</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Autism ; Biological and medical sciences ; California - epidemiology ; Case-Control Studies ; Child Development Disorders, Pervasive - epidemiology ; Child Development Disorders, Pervasive - etiology ; Child Development Disorders, Pervasive - genetics ; Child, Preschool ; Confounding Factors, Epidemiologic ; Developmental Disabilities - epidemiology ; Developmental Disabilities - etiology ; Developmental Disabilities - genetics ; Diet - adverse effects ; Dietary Supplements - analysis ; Feeding. Feeding behavior ; Female ; Folic Acid - administration & dosage ; Folic Acid Deficiency - physiopathology ; Food, Fortified - analysis ; Fundamental and applied biological sciences. Psychology ; Genetic Association Studies ; Growth, Development, and Pediatrics ; Humans ; Infant ; Male ; Maternal & child health ; Maternal Nutritional Physiological Phenomena ; Metabolism ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Methylenetetrahydrofolate Reductase (NADPH2) - metabolism ; Nutrition ; Polymorphism, Single Nucleotide ; Pregnancy ; Pregnancy Complications - physiopathology ; Pregnancy Trimester, First ; Risk ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin B</subject><ispartof>The American journal of clinical nutrition, 2012-07, Vol.96 (1), p.80-89</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jul 1, 2012</rights><rights>2012 American Society for Nutrition 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-879b5222ebe0e8b42f1bd204722bbadc77ca95e00bc905738581cc593167eeec3</citedby><cites>FETCH-LOGICAL-c517t-879b5222ebe0e8b42f1bd204722bbadc77ca95e00bc905738581cc593167eeec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26019916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22648721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHMIDT, Rebecca J</creatorcontrib><creatorcontrib>TANCREDI, Daniel J</creatorcontrib><creatorcontrib>OZONOFF, Sally</creatorcontrib><creatorcontrib>HANSEN, Robin L</creatorcontrib><creatorcontrib>HARTIALA, Jaana</creatorcontrib><creatorcontrib>ALLAYEE, Hooman</creatorcontrib><creatorcontrib>SCHMIDT, Linda C</creatorcontrib><creatorcontrib>TASSONE, Flora</creatorcontrib><creatorcontrib>HERTZ-PICCIOTTO, Irva</creatorcontrib><title>Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Periconceptional folate is essential for proper neurodevelopment.
Maternal folic acid intake was examined in relation to the risk of autism spectrum disorder (ASD) and developmental delay (DD).
Families enrolled in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study from 2003 to 2009 were included if their child had a diagnosis of ASD (n = 429), DD (n = 130), or typical development (TD; n = 278) confirmed at the University of California Davis Medical Investigation of Neurodevelopmental Disorders Institute by using standardized clinical assessments. Average daily folic acid was quantified for each mother on the basis of dose, brands, and intake frequency of vitamins, supplements, and breakfast cereals reported through structured telephone interviews.
Mean (±SEM) folic acid intake was significantly greater for mothers of TD children than for mothers of children with ASD in the first month of pregnancy (P1; 779.0 ± 36.1 and 655.0 ± 28.7 μg, respectively; P < 0.01). A mean daily folic acid intake of ≥600 μg (compared with <600 μg) during P1 was associated with reduced ASD risk (adjusted OR: 0.62; 95% CI: 0.42, 0.92; P = 0.02), and risk estimates decreased with increased folic acid (P-trend = 0.001). The association between folic acid and reduced ASD risk was strongest for mothers and children with MTHFR 677 C>T variant genotypes. A trend toward an association between lower maternal folic acid intake during the 3 mo before pregnancy and DD was observed, but not after adjustment for confounders.
Periconceptional folic acid may reduce ASD risk in those with inefficient folate metabolism. The replication of these findings and investigations of mechanisms involved are warranted.</description><subject>Autism</subject><subject>Biological and medical sciences</subject><subject>California - epidemiology</subject><subject>Case-Control Studies</subject><subject>Child Development Disorders, Pervasive - epidemiology</subject><subject>Child Development Disorders, Pervasive - etiology</subject><subject>Child Development Disorders, Pervasive - genetics</subject><subject>Child, Preschool</subject><subject>Confounding Factors, Epidemiologic</subject><subject>Developmental Disabilities - epidemiology</subject><subject>Developmental Disabilities - etiology</subject><subject>Developmental Disabilities - genetics</subject><subject>Diet - adverse effects</subject><subject>Dietary Supplements - analysis</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Folic Acid - administration & dosage</subject><subject>Folic Acid Deficiency - physiopathology</subject><subject>Food, Fortified - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Association Studies</subject><subject>Growth, Development, and Pediatrics</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Maternal & child health</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Metabolism</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - metabolism</subject><subject>Nutrition</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Pregnancy Trimester, First</subject><subject>Risk</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin B</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkl2L1DAUhoso7rh67Z0ERFgvupuPtmlvhGEYZ4QVYdHrkCanTmbTpibpwPw8_5npzrh-XIWTPHl4Q94se03wNWuK8kbu1XBN0oRxUZDqSbYgDatzRjF_mi0wxjRvSFVeZC9C2GNMaFFXz7MLSqui5pQssp-fZQQ_SItG8Ea5QcEYjZs3OmeNQlIZjcwQ5T0gOWjkTbhHrkNyiib0KIygop96pE1wXoMPD5SGA1g39pAu2jRZeUwSFHeAVtvl3WaNrlZbY_XOOY2WJ9VdMgfUedejDQwQjTq51sPBeDfMrvdIyQB5ihm9syjESR9fZs86aQO8Oq-X2beP66-rbX77ZfNptbzNVUl4zGvetCWlFFrAULcF7UirKS44pW0rteJcyaYEjFvV4JKzuqyJUmXDSMUBQLHL7MPJO05tD1qlOF5aMXrTS38UThrx78lgduK7OwjGeMFZkQRXZ4F3PyYIUfQmKLBWDuCmIAimpOG8LmlC3_6H7t00_9IDlVKXdckSdXOilHcheOgewxAs5nqIuR4i1UOc6pFuvPn7DY_87z4k4N0ZkEFJ23k5KBP-cBUmTSoU-wVcbce2</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>SCHMIDT, Rebecca J</creator><creator>TANCREDI, Daniel J</creator><creator>OZONOFF, Sally</creator><creator>HANSEN, Robin L</creator><creator>HARTIALA, Jaana</creator><creator>ALLAYEE, Hooman</creator><creator>SCHMIDT, Linda C</creator><creator>TASSONE, Flora</creator><creator>HERTZ-PICCIOTTO, Irva</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120701</creationdate><title>Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study</title><author>SCHMIDT, Rebecca J ; TANCREDI, Daniel J ; OZONOFF, Sally ; HANSEN, Robin L ; HARTIALA, Jaana ; ALLAYEE, Hooman ; SCHMIDT, Linda C ; TASSONE, Flora ; HERTZ-PICCIOTTO, Irva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-879b5222ebe0e8b42f1bd204722bbadc77ca95e00bc905738581cc593167eeec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Autism</topic><topic>Biological and medical sciences</topic><topic>California - epidemiology</topic><topic>Case-Control Studies</topic><topic>Child Development Disorders, Pervasive - epidemiology</topic><topic>Child Development Disorders, Pervasive - etiology</topic><topic>Child Development Disorders, Pervasive - genetics</topic><topic>Child, Preschool</topic><topic>Confounding Factors, Epidemiologic</topic><topic>Developmental Disabilities - epidemiology</topic><topic>Developmental Disabilities - etiology</topic><topic>Developmental Disabilities - genetics</topic><topic>Diet - adverse effects</topic><topic>Dietary Supplements - analysis</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Folic Acid - administration & dosage</topic><topic>Folic Acid Deficiency - physiopathology</topic><topic>Food, Fortified - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Association Studies</topic><topic>Growth, Development, and Pediatrics</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Maternal & child health</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Metabolism</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - metabolism</topic><topic>Nutrition</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Pregnancy Trimester, First</topic><topic>Risk</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHMIDT, Rebecca J</creatorcontrib><creatorcontrib>TANCREDI, Daniel J</creatorcontrib><creatorcontrib>OZONOFF, Sally</creatorcontrib><creatorcontrib>HANSEN, Robin L</creatorcontrib><creatorcontrib>HARTIALA, Jaana</creatorcontrib><creatorcontrib>ALLAYEE, Hooman</creatorcontrib><creatorcontrib>SCHMIDT, Linda C</creatorcontrib><creatorcontrib>TASSONE, Flora</creatorcontrib><creatorcontrib>HERTZ-PICCIOTTO, Irva</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHMIDT, Rebecca J</au><au>TANCREDI, Daniel J</au><au>OZONOFF, Sally</au><au>HANSEN, Robin L</au><au>HARTIALA, Jaana</au><au>ALLAYEE, Hooman</au><au>SCHMIDT, Linda C</au><au>TASSONE, Flora</au><au>HERTZ-PICCIOTTO, Irva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>96</volume><issue>1</issue><spage>80</spage><epage>89</epage><pages>80-89</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Periconceptional folate is essential for proper neurodevelopment.
Maternal folic acid intake was examined in relation to the risk of autism spectrum disorder (ASD) and developmental delay (DD).
Families enrolled in the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study from 2003 to 2009 were included if their child had a diagnosis of ASD (n = 429), DD (n = 130), or typical development (TD; n = 278) confirmed at the University of California Davis Medical Investigation of Neurodevelopmental Disorders Institute by using standardized clinical assessments. Average daily folic acid was quantified for each mother on the basis of dose, brands, and intake frequency of vitamins, supplements, and breakfast cereals reported through structured telephone interviews.
Mean (±SEM) folic acid intake was significantly greater for mothers of TD children than for mothers of children with ASD in the first month of pregnancy (P1; 779.0 ± 36.1 and 655.0 ± 28.7 μg, respectively; P < 0.01). A mean daily folic acid intake of ≥600 μg (compared with <600 μg) during P1 was associated with reduced ASD risk (adjusted OR: 0.62; 95% CI: 0.42, 0.92; P = 0.02), and risk estimates decreased with increased folic acid (P-trend = 0.001). The association between folic acid and reduced ASD risk was strongest for mothers and children with MTHFR 677 C>T variant genotypes. A trend toward an association between lower maternal folic acid intake during the 3 mo before pregnancy and DD was observed, but not after adjustment for confounders.
Periconceptional folic acid may reduce ASD risk in those with inefficient folate metabolism. The replication of these findings and investigations of mechanisms involved are warranted.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>22648721</pmid><doi>10.3945/ajcn.110.004416</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0002-9165 1938-3207 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Autism Biological and medical sciences California - epidemiology Case-Control Studies Child Development Disorders, Pervasive - epidemiology Child Development Disorders, Pervasive - etiology Child Development Disorders, Pervasive - genetics Child, Preschool Confounding Factors, Epidemiologic Developmental Disabilities - epidemiology Developmental Disabilities - etiology Developmental Disabilities - genetics Diet - adverse effects Dietary Supplements - analysis Feeding. Feeding behavior Female Folic Acid - administration & dosage Folic Acid Deficiency - physiopathology Food, Fortified - analysis Fundamental and applied biological sciences. Psychology Genetic Association Studies Growth, Development, and Pediatrics Humans Infant Male Maternal & child health Maternal Nutritional Physiological Phenomena Metabolism Methylenetetrahydrofolate Reductase (NADPH2) - genetics Methylenetetrahydrofolate Reductase (NADPH2) - metabolism Nutrition Polymorphism, Single Nucleotide Pregnancy Pregnancy Complications - physiopathology Pregnancy Trimester, First Risk Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin B |
| title | Maternal periconceptional folic acid intake and risk of autism spectrum disorders and developmental delay in the CHARGE (CHildhood Autism Risks from Genetics and Environment) case-control study |
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