Regional gray matter changes in obsessive–compulsive disorder: Relationship to clinical characteristics

Abstract Regional brain volumes were compared between 23 participants with obsessive–compulsive disorder (OCD) and 36 healthy controls using magnetic resonance imaging with voxel-based morphometry. A volumetric decrease in OCD was found in the right mediofrontal cortex. An increase was found in the...

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Veröffentlicht in:	Psychiatry research. Neuroimaging 2012-04, Vol.202 (1), p.74-76
Hauptverfasser:	Exner, Cornelia, Zetsche, Ulrike, Martin, Vera, Rief, Winfried, Jansen, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Anxiety disorders. Neuroses Biological and medical sciences Brain - pathology Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medial prefrontal cortex Medical sciences Middle Aged Nerve Fibers, Unmyelinated - pathology Neuroimaging Obsessive-Compulsive Disorder - pathology Obsessive-compulsive disorders Obsessive–compulsive disorder Organ Size Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiology Voxel-based morphometry
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Zusammenfassung:	Abstract Regional brain volumes were compared between 23 participants with obsessive–compulsive disorder (OCD) and 36 healthy controls using magnetic resonance imaging with voxel-based morphometry. A volumetric decrease in OCD was found in the right mediofrontal cortex. An increase was found in the left temporoparietal cortex. Volume alterations were related to symptom severity and age of onset.
ISSN:	0925-4927 1872-7506
DOI:	10.1016/j.pscychresns.2011.10.007