Postoperative radiation therapy for small, low-/intermediate-grade parotid tumors with close and/or positive surgical margins
Background Patients with small, low‐/intermediate‐risk parotid cancers, treated with surgery, and who have the single prognostic factor of close and/or positive margins, constitute an unusual subset. This study evaluates local control and morbidity associated with postoperative radiation therapy for...
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| Veröffentlicht in: | Head & neck 2012-07, Vol.34 (7), p.953-955 |
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| creator | Richter, Samuel M. Friedmann, Patricia Mourad, Waleed F. Hu, Kenneth S. Persky, Mark S. Harrison, Louis B. |
| description | Background
Patients with small, low‐/intermediate‐risk parotid cancers, treated with surgery, and who have the single prognostic factor of close and/or positive margins, constitute an unusual subset. This study evaluates local control and morbidity associated with postoperative radiation therapy for low/intermediate grade parotid cancer in these patients.
Methods
Between 1999 and 2006, 17 patients underwent postoperative radiation therapy at Beth Israel Medical Center for acinic cell carcinoma or low‐intermediate‐grade mucoepidermoid carcinoma of the parotid with close/positive margins. Pathology, treatment, and follow‐up data were retrospectively analyzed for morbidity and local control. Two‐ and 5‐year estimates of survival outcomes were performed followed by an analysis of complications.
Results
There were no local failures and no significant long‐term complications.
Conclusions
Patients with small, low‐risk cancer of the parotid gland have excellent local control and low treatment‐related morbidity when receiving postoperative radiation therapy for positive or close margins of resection. © 2011 Wiley Periodicals, Inc. Head Neck, 2012 |
| doi_str_mv | 10.1002/hed.21843 |
| format | Article |
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Patients with small, low‐/intermediate‐risk parotid cancers, treated with surgery, and who have the single prognostic factor of close and/or positive margins, constitute an unusual subset. This study evaluates local control and morbidity associated with postoperative radiation therapy for low/intermediate grade parotid cancer in these patients.
Methods
Between 1999 and 2006, 17 patients underwent postoperative radiation therapy at Beth Israel Medical Center for acinic cell carcinoma or low‐intermediate‐grade mucoepidermoid carcinoma of the parotid with close/positive margins. Pathology, treatment, and follow‐up data were retrospectively analyzed for morbidity and local control. Two‐ and 5‐year estimates of survival outcomes were performed followed by an analysis of complications.
Results
There were no local failures and no significant long‐term complications.
Conclusions
Patients with small, low‐risk cancer of the parotid gland have excellent local control and low treatment‐related morbidity when receiving postoperative radiation therapy for positive or close margins of resection. © 2011 Wiley Periodicals, Inc. Head Neck, 2012</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21843</identifier><identifier>PMID: 21850698</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Child ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; low/intermediate grade ; Male ; Medical sciences ; Middle Aged ; Otorhinolaryngology. Stomatology ; Parotid Gland - pathology ; Parotid Gland - radiation effects ; Parotid Neoplasms - radiotherapy ; Parotid Neoplasms - surgery ; parotid tumors ; positive/close margins ; Postoperative Care ; Radiation Injuries ; radiation therapy ; Radiotherapy, Adjuvant - adverse effects ; Retrospective Studies ; surgery ; Survival Analysis ; Young Adult</subject><ispartof>Head & neck, 2012-07, Vol.34 (7), p.953-955</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3933-ccf89710c10caf1fc6b2a91c6b00b6a49f6852870438df1badfc612a4a07b9643</citedby><cites>FETCH-LOGICAL-c3933-ccf89710c10caf1fc6b2a91c6b00b6a49f6852870438df1badfc612a4a07b9643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21843$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21843$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26050306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21850698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richter, Samuel M.</creatorcontrib><creatorcontrib>Friedmann, Patricia</creatorcontrib><creatorcontrib>Mourad, Waleed F.</creatorcontrib><creatorcontrib>Hu, Kenneth S.</creatorcontrib><creatorcontrib>Persky, Mark S.</creatorcontrib><creatorcontrib>Harrison, Louis B.</creatorcontrib><title>Postoperative radiation therapy for small, low-/intermediate-grade parotid tumors with close and/or positive surgical margins</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Patients with small, low‐/intermediate‐risk parotid cancers, treated with surgery, and who have the single prognostic factor of close and/or positive margins, constitute an unusual subset. This study evaluates local control and morbidity associated with postoperative radiation therapy for low/intermediate grade parotid cancer in these patients.
Methods
Between 1999 and 2006, 17 patients underwent postoperative radiation therapy at Beth Israel Medical Center for acinic cell carcinoma or low‐intermediate‐grade mucoepidermoid carcinoma of the parotid with close/positive margins. Pathology, treatment, and follow‐up data were retrospectively analyzed for morbidity and local control. Two‐ and 5‐year estimates of survival outcomes were performed followed by an analysis of complications.
Results
There were no local failures and no significant long‐term complications.
Conclusions
Patients with small, low‐risk cancer of the parotid gland have excellent local control and low treatment‐related morbidity when receiving postoperative radiation therapy for positive or close margins of resection. © 2011 Wiley Periodicals, Inc. Head Neck, 2012</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>low/intermediate grade</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Parotid Gland - pathology</subject><subject>Parotid Gland - radiation effects</subject><subject>Parotid Neoplasms - radiotherapy</subject><subject>Parotid Neoplasms - surgery</subject><subject>parotid tumors</subject><subject>positive/close margins</subject><subject>Postoperative Care</subject><subject>Radiation Injuries</subject><subject>radiation therapy</subject><subject>Radiotherapy, Adjuvant - adverse effects</subject><subject>Retrospective Studies</subject><subject>surgery</subject><subject>Survival Analysis</subject><subject>Young Adult</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9vFCEUB3BiNLZWD_4DhouJJk4XBoaZOTZr7ZrUHzFVEy-EYaCLMsMIjOse_N99293WkwkJL-TzHvBF6Cklp5SQcrE2_WlJG87uoWNK2rogjNf3dzVnBSM1P0KPUvpOCGGClw_REeCKiLY5Rn8-hpTDZKLK7pfBUfUOqjDivIazaYttiDgNyvtX2IdNsXBjNnEwO2aKa_AGTyqG7Hqc5yHEhDcur7H2IRmsxn4B_VNI7mZ8muO108rjQUExpsfogVU-mSeH_QR9fnN-tVwVlx8u3i7PLgvNWsYKrW3T1pRoWMpSq0VXqpbCRkgnFG-taKqyqeG7TW9pp3ogtFRckbprBWcn6MV-7hTDz9mkLAeXtPFejSbMSVJSUl5RzijQl3uqY0gpGiun6OC5W0Byl7aEtOVN2mCfHcbOHURyJ2_jBfD8AFSCb9uoRu3SPydIRRgR4BZ7t3HebP9_o1ydv769uth3uJTN77sOFX9IUbO6kl_fX8gv367esdWnVi7ZX9xEp5Q</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Richter, Samuel M.</creator><creator>Friedmann, Patricia</creator><creator>Mourad, Waleed F.</creator><creator>Hu, Kenneth S.</creator><creator>Persky, Mark S.</creator><creator>Harrison, Louis B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201207</creationdate><title>Postoperative radiation therapy for small, low-/intermediate-grade parotid tumors with close and/or positive surgical margins</title><author>Richter, Samuel M. ; Friedmann, Patricia ; Mourad, Waleed F. ; Hu, Kenneth S. ; Persky, Mark S. ; Harrison, Louis B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3933-ccf89710c10caf1fc6b2a91c6b00b6a49f6852870438df1badfc612a4a07b9643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>low/intermediate grade</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Parotid Gland - pathology</topic><topic>Parotid Gland - radiation effects</topic><topic>Parotid Neoplasms - radiotherapy</topic><topic>Parotid Neoplasms - surgery</topic><topic>parotid tumors</topic><topic>positive/close margins</topic><topic>Postoperative Care</topic><topic>Radiation Injuries</topic><topic>radiation therapy</topic><topic>Radiotherapy, Adjuvant - adverse effects</topic><topic>Retrospective Studies</topic><topic>surgery</topic><topic>Survival Analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richter, Samuel M.</creatorcontrib><creatorcontrib>Friedmann, Patricia</creatorcontrib><creatorcontrib>Mourad, Waleed F.</creatorcontrib><creatorcontrib>Hu, Kenneth S.</creatorcontrib><creatorcontrib>Persky, Mark S.</creatorcontrib><creatorcontrib>Harrison, Louis B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richter, Samuel M.</au><au>Friedmann, Patricia</au><au>Mourad, Waleed F.</au><au>Hu, Kenneth S.</au><au>Persky, Mark S.</au><au>Harrison, Louis B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative radiation therapy for small, low-/intermediate-grade parotid tumors with close and/or positive surgical margins</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2012-07</date><risdate>2012</risdate><volume>34</volume><issue>7</issue><spage>953</spage><epage>955</epage><pages>953-955</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Patients with small, low‐/intermediate‐risk parotid cancers, treated with surgery, and who have the single prognostic factor of close and/or positive margins, constitute an unusual subset. This study evaluates local control and morbidity associated with postoperative radiation therapy for low/intermediate grade parotid cancer in these patients.
Methods
Between 1999 and 2006, 17 patients underwent postoperative radiation therapy at Beth Israel Medical Center for acinic cell carcinoma or low‐intermediate‐grade mucoepidermoid carcinoma of the parotid with close/positive margins. Pathology, treatment, and follow‐up data were retrospectively analyzed for morbidity and local control. Two‐ and 5‐year estimates of survival outcomes were performed followed by an analysis of complications.
Results
There were no local failures and no significant long‐term complications.
Conclusions
Patients with small, low‐risk cancer of the parotid gland have excellent local control and low treatment‐related morbidity when receiving postoperative radiation therapy for positive or close margins of resection. © 2011 Wiley Periodicals, Inc. Head Neck, 2012</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21850698</pmid><doi>10.1002/hed.21843</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Child Female Follow-Up Studies Humans Kaplan-Meier Estimate low/intermediate grade Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology Parotid Gland - pathology Parotid Gland - radiation effects Parotid Neoplasms - radiotherapy Parotid Neoplasms - surgery parotid tumors positive/close margins Postoperative Care Radiation Injuries radiation therapy Radiotherapy, Adjuvant - adverse effects Retrospective Studies surgery Survival Analysis Young Adult |
| title | Postoperative radiation therapy for small, low-/intermediate-grade parotid tumors with close and/or positive surgical margins |
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