Amoebicidal activity of the rhizomes and aerial parts of Allium sivasicum on Entamoeba histolytica
Amebiasis is a severe illness caused by Entamoebachistolytica . The aim of this study is to evaluate the in vitro amebicidal activity of the rhizomes and aerial parts of Allium sivasicum , an endemic plant species from the flora of Turkey. Both extracts showed a time- and dose-dependent amebicidal a...
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| Veröffentlicht in: | Parasitology research (1987) 2012-07, Vol.111 (1), p.59-64 |
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| creator | Degerli, S. Berk, S. Tepe, B. Malatyali, E. |
| description | Amebiasis is a severe illness caused by
Entamoebachistolytica
. The aim of this study is to evaluate the in vitro amebicidal activity of the rhizomes and aerial parts of
Allium sivasicum
, an endemic plant species from the flora of Turkey. Both extracts showed a time- and dose-dependent amebicidal action on the trophozoites. Among the extracts tested, rhizomes of
A. sivasicum
showed the strongest amebicidal effect on the trophozoites. In the presence of the rhizome extract at 2.0 mg/ml concentration, all of the trophozoites available in media have completely been killed within the 72nd hour. At 4.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the rhizome extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 73.7% of the trophozoites were successfully killed by the extract within the first experimental hour. Aerial part extract at 4.0 mg/ml concentration completely killed the trophozoited within the 48th hour of the experimental procedure. At 8.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the aerial part extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 67.7% of the trophozoites were successfully killed by the extract within the first experimental hour. These results suggest that the plant species evaluated here is a potential therapeutic drug for the treatment of
Entamoeba
infections, but it still needs to be evaluated quantitatively for determining the active phytochemicals. |
| doi_str_mv | 10.1007/s00436-011-2801-x |
| format | Article |
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Entamoebachistolytica
. The aim of this study is to evaluate the in vitro amebicidal activity of the rhizomes and aerial parts of
Allium sivasicum
, an endemic plant species from the flora of Turkey. Both extracts showed a time- and dose-dependent amebicidal action on the trophozoites. Among the extracts tested, rhizomes of
A. sivasicum
showed the strongest amebicidal effect on the trophozoites. In the presence of the rhizome extract at 2.0 mg/ml concentration, all of the trophozoites available in media have completely been killed within the 72nd hour. At 4.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the rhizome extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 73.7% of the trophozoites were successfully killed by the extract within the first experimental hour. Aerial part extract at 4.0 mg/ml concentration completely killed the trophozoited within the 48th hour of the experimental procedure. At 8.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the aerial part extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 67.7% of the trophozoites were successfully killed by the extract within the first experimental hour. These results suggest that the plant species evaluated here is a potential therapeutic drug for the treatment of
Entamoeba
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Entamoebachistolytica
. The aim of this study is to evaluate the in vitro amebicidal activity of the rhizomes and aerial parts of
Allium sivasicum
, an endemic plant species from the flora of Turkey. Both extracts showed a time- and dose-dependent amebicidal action on the trophozoites. Among the extracts tested, rhizomes of
A. sivasicum
showed the strongest amebicidal effect on the trophozoites. In the presence of the rhizome extract at 2.0 mg/ml concentration, all of the trophozoites available in media have completely been killed within the 72nd hour. At 4.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the rhizome extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 73.7% of the trophozoites were successfully killed by the extract within the first experimental hour. Aerial part extract at 4.0 mg/ml concentration completely killed the trophozoited within the 48th hour of the experimental procedure. At 8.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the aerial part extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 67.7% of the trophozoites were successfully killed by the extract within the first experimental hour. These results suggest that the plant species evaluated here is a potential therapeutic drug for the treatment of
Entamoeba
infections, but it still needs to be evaluated quantitatively for determining the active phytochemicals.</description><subject>Allium - chemistry</subject><subject>Antiprotozoal Agents - isolation & purification</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Survival - drug effects</subject><subject>Child, Preschool</subject><subject>Entamoeba histolytica - drug effects</subject><subject>Entamoeba histolytica - isolation & purification</subject><subject>Entamoebiasis - parasitology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunology</subject><subject>Invertebrates</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Original Paper</subject><subject>Physiological aspects</subject><subject>Phytochemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Protozoa</subject><subject>Rhizome - chemistry</subject><subject>Sediments (Geology)</subject><subject>Stems (Botany)</subject><subject>Time Factors</subject><subject>Turkey</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhS1ERYeBH8Cm8gaJTVq_kkyWo6o8pEpsYG3d-NFx5diD7VQdfj2OMpQd8sJXvt85vjoXoQ-UXFNC-ptMiOBdQyht2I7Q5vkV2lDBWUOHtn2NNmSode3yS_Q250dCaN8J8QZdMsZoS4dug8b9FM3olNPgMajinlw54WhxORicDu53nEzGEDQGk1xljpBKXoC9926ecHZPkJ2qVQz4LhRY_AAfXC7Rn4pT8A5dWPDZvD_fW_Tz892P26_N_fcv3273940S_VAaPhjSGyGEstqyWlpFRg07xa01loyKckJaxZTmTJlx1L3uBIihGwYi2sHyLfq0-h5T_DWbXOTksjLeQzBxzpISRkVLedtX9HpFH8Ab6YKNJYGqR5vJqRiMdfV9z0m3RNjtqoCuApVizslYeUxugnSqrnLZhVx3IWvactmFfK6aq_M88zgZ_aL4G34FPp4ByAq8TRCUy_-4jtJe1AG2iK1crq3wYJJ8jHMKNcv__P4Hldmi6w</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Degerli, S.</creator><creator>Berk, S.</creator><creator>Tepe, B.</creator><creator>Malatyali, E.</creator><general>Springer-Verlag</general><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Amoebicidal activity of the rhizomes and aerial parts of Allium sivasicum on Entamoeba histolytica</title><author>Degerli, S. ; Berk, S. ; Tepe, B. ; Malatyali, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-39e07e444cfdf207efc0bda8c3ffef0bc13005c2cd32cebbd7d64a496990459f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Allium - chemistry</topic><topic>Antiprotozoal Agents - isolation & purification</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Survival - drug effects</topic><topic>Child, Preschool</topic><topic>Entamoeba histolytica - drug effects</topic><topic>Entamoeba histolytica - isolation & purification</topic><topic>Entamoebiasis - parasitology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunology</topic><topic>Invertebrates</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Original Paper</topic><topic>Physiological aspects</topic><topic>Phytochemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Protozoa</topic><topic>Rhizome - chemistry</topic><topic>Sediments (Geology)</topic><topic>Stems (Botany)</topic><topic>Time Factors</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Degerli, S.</creatorcontrib><creatorcontrib>Berk, S.</creatorcontrib><creatorcontrib>Tepe, B.</creatorcontrib><creatorcontrib>Malatyali, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Degerli, S.</au><au>Berk, S.</au><au>Tepe, B.</au><au>Malatyali, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amoebicidal activity of the rhizomes and aerial parts of Allium sivasicum on Entamoeba histolytica</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>111</volume><issue>1</issue><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>Amebiasis is a severe illness caused by
Entamoebachistolytica
. The aim of this study is to evaluate the in vitro amebicidal activity of the rhizomes and aerial parts of
Allium sivasicum
, an endemic plant species from the flora of Turkey. Both extracts showed a time- and dose-dependent amebicidal action on the trophozoites. Among the extracts tested, rhizomes of
A. sivasicum
showed the strongest amebicidal effect on the trophozoites. In the presence of the rhizome extract at 2.0 mg/ml concentration, all of the trophozoites available in media have completely been killed within the 72nd hour. At 4.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the rhizome extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 73.7% of the trophozoites were successfully killed by the extract within the first experimental hour. Aerial part extract at 4.0 mg/ml concentration completely killed the trophozoited within the 48th hour of the experimental procedure. At 8.0 mg/ml extract concentration, all of the trophozoites available in media have completely been killed by the aerial part extract from the time of 24th hour. At 32.0 mg/ml extract concentration, 67.7% of the trophozoites were successfully killed by the extract within the first experimental hour. These results suggest that the plant species evaluated here is a potential therapeutic drug for the treatment of
Entamoeba
infections, but it still needs to be evaluated quantitatively for determining the active phytochemicals.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22215196</pmid><doi>10.1007/s00436-011-2801-x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2012-07, Vol.111 (1), p.59-64 |
| issn | 0932-0113 1432-1955 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Allium - chemistry Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cell Survival - drug effects Child, Preschool Entamoeba histolytica - drug effects Entamoeba histolytica - isolation & purification Entamoebiasis - parasitology Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Health aspects Humans Immunology Invertebrates Medical Microbiology Microbiology Original Paper Physiological aspects Phytochemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Protozoa Rhizome - chemistry Sediments (Geology) Stems (Botany) Time Factors Turkey |
| title | Amoebicidal activity of the rhizomes and aerial parts of Allium sivasicum on Entamoeba histolytica |
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