In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention
Purpose Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan; it ranks top three in the cancer mortality rate. Curcuminoids are derived from the rhizome of Curcuma longa . It has shown anti-cancer activity and apoptosis induction in a variety of cancer cell lines. This aims t...
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| Veröffentlicht in: | International journal of colorectal disease 2012-07, Vol.27 (7), p.869-878 |
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| container_title | International journal of colorectal disease |
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| creator | Chen, Ming-Jenn Cheng, Ya-Min Lai, Pei-Heng Wu, June-Fu Hsu, Yi-Chiang |
| description | Purpose
Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan; it ranks top three in the cancer mortality rate. Curcuminoids are derived from the rhizome of
Curcuma longa
. It has shown anti-cancer activity and apoptosis induction in a variety of cancer cell lines. This aims to study the potential of Poloxamer 407 as the thermogelling and mucoadhesive polymer for development of a site-targeting delivery system to enhance the localized delivery of curcuminoids to the colorectal cells for CRC chemotherapy.
Methods
The mucoadhesive strength and rheological properties were measured as a function of poloxamer loaded with curcuminoids.
Results
The gelation temperature of Poloxamer 407 was found to vary with its concentration and start gelling at 37°C at the concentration of 15.5% (
w/v
). To ensure gelation at physiological temperature after intra-rectal application, gelation temperature was determined by rheological measurement as well as by its physical appearance. The results indicated that its mucoadhesive strength also shows a dependency on temperature, which appears to be related to the increment in the maximum strength and average strength of the polymer.
Conclusion
The results have suggested that Poloxamer 407 could be a potential thermogelling and mucoadhesive polymer for the development of a site-targeting colorectal drug delivery system for curcuminoids in colorectal cancer therapy.
Figure
Poloxamer 407 could be a potential polymer for the development of a site-targeting colorectal drug delivery system (DDS) for curcuminoids in colorectal cancer therapy. |
| doi_str_mv | 10.1007/s00384-011-1393-3 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1021449793</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714491406</galeid><sourcerecordid>A714491406</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-1aa29ecc671e4dbed544999b708dfc0d018384f61480a9c9283d18795242f00a3</originalsourceid><addsrcrecordid>eNp1kU1v3CAQhlHVqNmm_QG9VEi99OKErzXmGEVtGilSL-kZYRjvEmHYgL3SKn--WJukH2rhwADPvMzwIvSBknNKiLwohPBONITShnLFG_4KrajgrKGsZa_RilCpGqrW3Sl6W8o9qftWijfolC1DtOsVeryJeO-nnHDvk03jzky-98FPB5wGPG0hjyaEA95ACD5ucPAPs3d4nG0ybgvF7wGHGoLDds52Hn1M3hXsI7YppAx2MgFbEy1kbLcwpl2GPcTJp_gOnQwmFHj_tJ6hH1-_3F19a26_X99cXd42VnA1NdQYpsDaVlIQrge3FkIp1UvSucESR2hXf2FoqeiIUVaxjjvaSbVmgg2EGH6GPh91dzk9zFAmPfpia0MmQpqLpoTRKikVr-inv9D7NOdYq6sUZ1J2bUt_URsTQPs4pCkbu4jqS7lIUUHaSp3_g6rTwehtijD4ev5HAj0m2JxKyTDoXfajyYf6tl4M10fDdTVcL4brpeCPTwXP_QjuJePZ4QqwI1DqVdxA_r2j_6n-BIj6tdg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1032778661</pqid></control><display><type>article</type><title>In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chen, Ming-Jenn ; Cheng, Ya-Min ; Lai, Pei-Heng ; Wu, June-Fu ; Hsu, Yi-Chiang</creator><creatorcontrib>Chen, Ming-Jenn ; Cheng, Ya-Min ; Lai, Pei-Heng ; Wu, June-Fu ; Hsu, Yi-Chiang</creatorcontrib><description>Purpose
Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan; it ranks top three in the cancer mortality rate. Curcuminoids are derived from the rhizome of
Curcuma longa
. It has shown anti-cancer activity and apoptosis induction in a variety of cancer cell lines. This aims to study the potential of Poloxamer 407 as the thermogelling and mucoadhesive polymer for development of a site-targeting delivery system to enhance the localized delivery of curcuminoids to the colorectal cells for CRC chemotherapy.
Methods
The mucoadhesive strength and rheological properties were measured as a function of poloxamer loaded with curcuminoids.
Results
The gelation temperature of Poloxamer 407 was found to vary with its concentration and start gelling at 37°C at the concentration of 15.5% (
w/v
). To ensure gelation at physiological temperature after intra-rectal application, gelation temperature was determined by rheological measurement as well as by its physical appearance. The results indicated that its mucoadhesive strength also shows a dependency on temperature, which appears to be related to the increment in the maximum strength and average strength of the polymer.
Conclusion
The results have suggested that Poloxamer 407 could be a potential thermogelling and mucoadhesive polymer for the development of a site-targeting colorectal drug delivery system for curcuminoids in colorectal cancer therapy.
Figure
Poloxamer 407 could be a potential polymer for the development of a site-targeting colorectal drug delivery system (DDS) for curcuminoids in colorectal cancer therapy.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-011-1393-3</identifier><identifier>PMID: 22222465</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adhesives - pharmacology ; Aged ; Aged, 80 and over ; Apoptosis ; Biocompatible Materials - pharmacology ; Cancer ; Care and treatment ; Cell Death - drug effects ; Cell Survival - drug effects ; Chemoprevention ; Colorectal cancer ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - prevention & control ; Curcumin - pharmacology ; Curcumin - therapeutic use ; Drug Delivery Systems ; Drugs ; Female ; Gastroenterology ; Gels - chemistry ; Health aspects ; Hepatology ; Humans ; Internal Medicine ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - pathology ; Male ; Materials Testing ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Physiological aspects ; Poloxamer - chemistry ; Polymers ; Prevention ; Proctology ; Rankings ; Suppositories - pharmacology ; Surgery ; Temperature ; Vehicles</subject><ispartof>International journal of colorectal disease, 2012-07, Vol.27 (7), p.869-878</ispartof><rights>Springer-Verlag 2011</rights><rights>COPYRIGHT 2012 Springer</rights><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-1aa29ecc671e4dbed544999b708dfc0d018384f61480a9c9283d18795242f00a3</citedby><cites>FETCH-LOGICAL-c439t-1aa29ecc671e4dbed544999b708dfc0d018384f61480a9c9283d18795242f00a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-011-1393-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-011-1393-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22222465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ming-Jenn</creatorcontrib><creatorcontrib>Cheng, Ya-Min</creatorcontrib><creatorcontrib>Lai, Pei-Heng</creatorcontrib><creatorcontrib>Wu, June-Fu</creatorcontrib><creatorcontrib>Hsu, Yi-Chiang</creatorcontrib><title>In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purpose
Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan; it ranks top three in the cancer mortality rate. Curcuminoids are derived from the rhizome of
Curcuma longa
. It has shown anti-cancer activity and apoptosis induction in a variety of cancer cell lines. This aims to study the potential of Poloxamer 407 as the thermogelling and mucoadhesive polymer for development of a site-targeting delivery system to enhance the localized delivery of curcuminoids to the colorectal cells for CRC chemotherapy.
Methods
The mucoadhesive strength and rheological properties were measured as a function of poloxamer loaded with curcuminoids.
Results
The gelation temperature of Poloxamer 407 was found to vary with its concentration and start gelling at 37°C at the concentration of 15.5% (
w/v
). To ensure gelation at physiological temperature after intra-rectal application, gelation temperature was determined by rheological measurement as well as by its physical appearance. The results indicated that its mucoadhesive strength also shows a dependency on temperature, which appears to be related to the increment in the maximum strength and average strength of the polymer.
Conclusion
The results have suggested that Poloxamer 407 could be a potential thermogelling and mucoadhesive polymer for the development of a site-targeting colorectal drug delivery system for curcuminoids in colorectal cancer therapy.
Figure
Poloxamer 407 could be a potential polymer for the development of a site-targeting colorectal drug delivery system (DDS) for curcuminoids in colorectal cancer therapy.</description><subject>Adhesives - pharmacology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Apoptosis</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Cell Death - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Chemoprevention</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - prevention & control</subject><subject>Curcumin - pharmacology</subject><subject>Curcumin - therapeutic use</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gels - chemistry</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - pathology</subject><subject>Male</subject><subject>Materials Testing</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Physiological aspects</subject><subject>Poloxamer - chemistry</subject><subject>Polymers</subject><subject>Prevention</subject><subject>Proctology</subject><subject>Rankings</subject><subject>Suppositories - pharmacology</subject><subject>Surgery</subject><subject>Temperature</subject><subject>Vehicles</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v3CAQhlHVqNmm_QG9VEi99OKErzXmGEVtGilSL-kZYRjvEmHYgL3SKn--WJukH2rhwADPvMzwIvSBknNKiLwohPBONITShnLFG_4KrajgrKGsZa_RilCpGqrW3Sl6W8o9qftWijfolC1DtOsVeryJeO-nnHDvk03jzky-98FPB5wGPG0hjyaEA95ACD5ucPAPs3d4nG0ybgvF7wGHGoLDds52Hn1M3hXsI7YppAx2MgFbEy1kbLcwpl2GPcTJp_gOnQwmFHj_tJ6hH1-_3F19a26_X99cXd42VnA1NdQYpsDaVlIQrge3FkIp1UvSucESR2hXf2FoqeiIUVaxjjvaSbVmgg2EGH6GPh91dzk9zFAmPfpia0MmQpqLpoTRKikVr-inv9D7NOdYq6sUZ1J2bUt_URsTQPs4pCkbu4jqS7lIUUHaSp3_g6rTwehtijD4ev5HAj0m2JxKyTDoXfajyYf6tl4M10fDdTVcL4brpeCPTwXP_QjuJePZ4QqwI1DqVdxA_r2j_6n-BIj6tdg</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Chen, Ming-Jenn</creator><creator>Cheng, Ya-Min</creator><creator>Lai, Pei-Heng</creator><creator>Wu, June-Fu</creator><creator>Hsu, Yi-Chiang</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention</title><author>Chen, Ming-Jenn ; Cheng, Ya-Min ; Lai, Pei-Heng ; Wu, June-Fu ; Hsu, Yi-Chiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-1aa29ecc671e4dbed544999b708dfc0d018384f61480a9c9283d18795242f00a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adhesives - pharmacology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Apoptosis</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Cell Death - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Chemoprevention</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - prevention & control</topic><topic>Curcumin - pharmacology</topic><topic>Curcumin - therapeutic use</topic><topic>Drug Delivery Systems</topic><topic>Drugs</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gels - chemistry</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - pathology</topic><topic>Male</topic><topic>Materials Testing</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Physiological aspects</topic><topic>Poloxamer - chemistry</topic><topic>Polymers</topic><topic>Prevention</topic><topic>Proctology</topic><topic>Rankings</topic><topic>Suppositories - pharmacology</topic><topic>Surgery</topic><topic>Temperature</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ming-Jenn</creatorcontrib><creatorcontrib>Cheng, Ya-Min</creatorcontrib><creatorcontrib>Lai, Pei-Heng</creatorcontrib><creatorcontrib>Wu, June-Fu</creatorcontrib><creatorcontrib>Hsu, Yi-Chiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ming-Jenn</au><au>Cheng, Ya-Min</au><au>Lai, Pei-Heng</au><au>Wu, June-Fu</au><au>Hsu, Yi-Chiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>27</volume><issue>7</issue><spage>869</spage><epage>878</epage><pages>869-878</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Purpose
Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan; it ranks top three in the cancer mortality rate. Curcuminoids are derived from the rhizome of
Curcuma longa
. It has shown anti-cancer activity and apoptosis induction in a variety of cancer cell lines. This aims to study the potential of Poloxamer 407 as the thermogelling and mucoadhesive polymer for development of a site-targeting delivery system to enhance the localized delivery of curcuminoids to the colorectal cells for CRC chemotherapy.
Methods
The mucoadhesive strength and rheological properties were measured as a function of poloxamer loaded with curcuminoids.
Results
The gelation temperature of Poloxamer 407 was found to vary with its concentration and start gelling at 37°C at the concentration of 15.5% (
w/v
). To ensure gelation at physiological temperature after intra-rectal application, gelation temperature was determined by rheological measurement as well as by its physical appearance. The results indicated that its mucoadhesive strength also shows a dependency on temperature, which appears to be related to the increment in the maximum strength and average strength of the polymer.
Conclusion
The results have suggested that Poloxamer 407 could be a potential thermogelling and mucoadhesive polymer for the development of a site-targeting colorectal drug delivery system for curcuminoids in colorectal cancer therapy.
Figure
Poloxamer 407 could be a potential polymer for the development of a site-targeting colorectal drug delivery system (DDS) for curcuminoids in colorectal cancer therapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22222465</pmid><doi>10.1007/s00384-011-1393-3</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2012-07, Vol.27 (7), p.869-878 |
| issn | 0179-1958 1432-1262 |
| language | eng |
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| subjects | Adhesives - pharmacology Aged Aged, 80 and over Apoptosis Biocompatible Materials - pharmacology Cancer Care and treatment Cell Death - drug effects Cell Survival - drug effects Chemoprevention Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - prevention & control Curcumin - pharmacology Curcumin - therapeutic use Drug Delivery Systems Drugs Female Gastroenterology Gels - chemistry Health aspects Hepatology Humans Internal Medicine Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Male Materials Testing Medicine Medicine & Public Health Middle Aged Original Article Physiological aspects Poloxamer - chemistry Polymers Prevention Proctology Rankings Suppositories - pharmacology Surgery Temperature Vehicles |
| title | In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention |
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