Usefulness of alpha-fetoprotein response in patients treated with sorafenib for advanced hepatocellular carcinoma

Background & Aims Tumor shrinkage has been considered a fundamental surrogate efficacy measure for new cancer treatments. However, in patients treated with sorafenib for advanced hepatocellular carcinoma (HCC), tumor shrinkage rarely accompanies increased survival, thereby questioning the progno...

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Veröffentlicht in:	Journal of hepatology 2012-07, Vol.57 (1), p.101-107
Hauptverfasser:	Personeni, Nicola, Bozzarelli, Silvia, Pressiani, Tiziana, Rimassa, Lorenza, Tronconi, Maria Chiara, Sclafani, Francesco, Carnaghi, Carlo, Pedicini, Vittorio, Giordano, Laura, Santoro, Armando
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AFP response Aged Aged, 80 and over Alpha-fetoprotein alpha-Fetoproteins - metabolism Antineoplastic Agents - therapeutic use Benzenesulfonates - therapeutic use Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Drug Monitoring - methods Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Hepatocellular carcinoma Humans Landmark analysis Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Niacinamide - analogs & derivatives Phenylurea Compounds Prognosis Proportional Hazards Models Pyridines - therapeutic use RECIST Retrospective Studies Sorafenib Survival Treatment Outcome Tumors
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