Prediction of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery

Objective We sought to determine the value of preoperative left ventricular function and cardiopulmonary bypass parameters in the prediction of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery. Methods Multivariate logistic regressi...

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Veröffentlicht in:The Journal of thoracic and cardiovascular surgery 2012-07, Vol.144 (1), p.160-165
Hauptverfasser: Edwin, Frank, MD, Kinsley, Robin H., MD, Quarshie, Alexander, MD, MS, Colsen, Peter R., MD
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container_issue 1
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container_title The Journal of thoracic and cardiovascular surgery
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creator Edwin, Frank, MD
Kinsley, Robin H., MD
Quarshie, Alexander, MD, MS
Colsen, Peter R., MD
description Objective We sought to determine the value of preoperative left ventricular function and cardiopulmonary bypass parameters in the prediction of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery. Methods Multivariate logistic regression was performed to identify a predictive model for postrepair left ventricular assist device implantation using the records of 27 patients who underwent direct aortic implantation of anomalous left coronary artery from the pulmonary artery from 1994 to 2011. Results Seven patients required left ventricular assist device implantation. Patients in group 1 (n = 20) were successfully weaned from cardiopulmonary bypass. Patients in group 2 (n = 7) required left ventricular assist device as a bridge to recovery. The 2 groups were similar in age, weight, and body surface area. Six of the 7 patients (85.7%) who required left ventricular assist device survived to hospital discharge. Hospital mortality was 3.7%. In the univariate model, fractional shortening, ejection fraction, and aortic crossclamp time were significantly associated with left ventricular assist device implantation ( P  = .026, .035, .031, respectively). In the multivariate analysis, the aortic crossclamp time was the only significant independent predictor of left ventricular assist device implantation. Aortic crossclamp time and fractional shortening together accounted for 80.9% ( P  
doi_str_mv 10.1016/j.jtcvs.2011.12.004
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Methods Multivariate logistic regression was performed to identify a predictive model for postrepair left ventricular assist device implantation using the records of 27 patients who underwent direct aortic implantation of anomalous left coronary artery from the pulmonary artery from 1994 to 2011. Results Seven patients required left ventricular assist device implantation. Patients in group 1 (n = 20) were successfully weaned from cardiopulmonary bypass. Patients in group 2 (n = 7) required left ventricular assist device as a bridge to recovery. The 2 groups were similar in age, weight, and body surface area. Six of the 7 patients (85.7%) who required left ventricular assist device survived to hospital discharge. Hospital mortality was 3.7%. In the univariate model, fractional shortening, ejection fraction, and aortic crossclamp time were significantly associated with left ventricular assist device implantation ( P  = .026, .035, .031, respectively). In the multivariate analysis, the aortic crossclamp time was the only significant independent predictor of left ventricular assist device implantation. Aortic crossclamp time and fractional shortening together accounted for 80.9% ( P  &lt; .001) of the variability in left ventricular assist device implantation and constituted the best predictive model: All patients requiring postrepair left ventricular assist device implantation had a fractional shortening less than 20% and an aortic crossclamp time greater than 56 minutes. Conclusions The fractional shortening and aortic crossclamp time together predict 80.9% of the variability in postrepair left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery. When preoperative left ventricular dysfunction is severe (fractional shortening &lt; 20%), an aortic crossclamp time greater than 56 minutes is associated with a substantial risk of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/j.jtcvs.2011.12.004</identifier><identifier>PMID: 22188820</identifier><identifier>CODEN: JTCSAQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiopulmonary Bypass ; Cardiothoracic Surgery ; Chi-Square Distribution ; Coronary Vessel Anomalies - mortality ; Coronary Vessel Anomalies - surgery ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Female ; Heart Function Tests ; Heart-Assist Devices ; Hospital Mortality ; Humans ; Infant ; Intensive care medicine ; Logistic Models ; Male ; Medical sciences ; Pneumology ; Predictive Value of Tests ; Pulmonary Artery - abnormalities ; Retrospective Studies ; Sternotomy ; Survival Analysis ; Treatment Outcome ; Ventricular Function, Left</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 2012-07, Vol.144 (1), p.160-165</ispartof><rights>The American Association for Thoracic Surgery</rights><rights>2012 The American Association for Thoracic Surgery</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. 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Methods Multivariate logistic regression was performed to identify a predictive model for postrepair left ventricular assist device implantation using the records of 27 patients who underwent direct aortic implantation of anomalous left coronary artery from the pulmonary artery from 1994 to 2011. Results Seven patients required left ventricular assist device implantation. Patients in group 1 (n = 20) were successfully weaned from cardiopulmonary bypass. Patients in group 2 (n = 7) required left ventricular assist device as a bridge to recovery. The 2 groups were similar in age, weight, and body surface area. Six of the 7 patients (85.7%) who required left ventricular assist device survived to hospital discharge. Hospital mortality was 3.7%. In the univariate model, fractional shortening, ejection fraction, and aortic crossclamp time were significantly associated with left ventricular assist device implantation ( P  = .026, .035, .031, respectively). In the multivariate analysis, the aortic crossclamp time was the only significant independent predictor of left ventricular assist device implantation. Aortic crossclamp time and fractional shortening together accounted for 80.9% ( P  &lt; .001) of the variability in left ventricular assist device implantation and constituted the best predictive model: All patients requiring postrepair left ventricular assist device implantation had a fractional shortening less than 20% and an aortic crossclamp time greater than 56 minutes. Conclusions The fractional shortening and aortic crossclamp time together predict 80.9% of the variability in postrepair left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery. When preoperative left ventricular dysfunction is severe (fractional shortening &lt; 20%), an aortic crossclamp time greater than 56 minutes is associated with a substantial risk of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiopulmonary Bypass</subject><subject>Cardiothoracic Surgery</subject><subject>Chi-Square Distribution</subject><subject>Coronary Vessel Anomalies - mortality</subject><subject>Coronary Vessel Anomalies - surgery</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Female</subject><subject>Heart Function Tests</subject><subject>Heart-Assist Devices</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Infant</subject><subject>Intensive care medicine</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Predictive Value of Tests</subject><subject>Pulmonary Artery - abnormalities</subject><subject>Retrospective Studies</subject><subject>Sternotomy</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2r1DAUhoMo3vHqLxAkG8FN60naadOFwuXiF1xQUMFdyJyeYGrbjEk6MFt_uemd8QM3rrLI855z8uQw9lhAKUA0z4dySHiIpQQhSiFLgPoO2wjo2qJR2y932QZAymIrZXXBHsQ4AEALorvPLqQUSikJG_bjQ6DeYXJ-5t7ykWziB5pTcLiMJnATo4uJ93RwSNxN-9HMydzixiYKPNDeuLBmzewnM_olnqqgD3424chNyNyR2-Annr4S3y_j9PfNQ3bPmjHSo_N5yT6_fvXp-m1x8_7Nu-urmwJr1aUCqe6k6SWZCmuADm29a6lH0dYgsLa7rm-gsk3TkYJdLVRTNdgb2RtUXWarS_bsVHcf_PeFYtKTi0hjfhHlqbUAKWQDsO0yWp1QDD7GQFbvg5vyyBnSq3w96Fv5epWvhdRZfk49OTdYdhP1vzO_bGfg6RkwEc1og5nRxT9cA6IFJTP34sRR1nFwFHRERzPmnwqESffe_WeQl__kcXSzyy2_0ZHi4JcwZ9Na6JgD-uO6J-uaiFyxUlJUPwEyfLwv</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Edwin, Frank, MD</creator><creator>Kinsley, Robin H., MD</creator><creator>Quarshie, Alexander, MD, MS</creator><creator>Colsen, Peter R., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120701</creationdate><title>Prediction of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery</title><author>Edwin, Frank, MD ; Kinsley, Robin H., MD ; Quarshie, Alexander, MD, MS ; Colsen, Peter R., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-ce492ad2ea3c4009cf4b7edc17401c4fb9d603f669e80b418636cda2dac89f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiopulmonary Bypass</topic><topic>Cardiothoracic Surgery</topic><topic>Chi-Square Distribution</topic><topic>Coronary Vessel Anomalies - mortality</topic><topic>Coronary Vessel Anomalies - surgery</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Female</topic><topic>Heart Function Tests</topic><topic>Heart-Assist Devices</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Infant</topic><topic>Intensive care medicine</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>Predictive Value of Tests</topic><topic>Pulmonary Artery - abnormalities</topic><topic>Retrospective Studies</topic><topic>Sternotomy</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Edwin, Frank, MD</creatorcontrib><creatorcontrib>Kinsley, Robin H., MD</creatorcontrib><creatorcontrib>Quarshie, Alexander, MD, MS</creatorcontrib><creatorcontrib>Colsen, Peter R., MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Edwin, Frank, MD</au><au>Kinsley, Robin H., MD</au><au>Quarshie, Alexander, MD, MS</au><au>Colsen, Peter R., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prediction of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>144</volume><issue>1</issue><spage>160</spage><epage>165</epage><pages>160-165</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><coden>JTCSAQ</coden><abstract>Objective We sought to determine the value of preoperative left ventricular function and cardiopulmonary bypass parameters in the prediction of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery. Methods Multivariate logistic regression was performed to identify a predictive model for postrepair left ventricular assist device implantation using the records of 27 patients who underwent direct aortic implantation of anomalous left coronary artery from the pulmonary artery from 1994 to 2011. Results Seven patients required left ventricular assist device implantation. Patients in group 1 (n = 20) were successfully weaned from cardiopulmonary bypass. Patients in group 2 (n = 7) required left ventricular assist device as a bridge to recovery. The 2 groups were similar in age, weight, and body surface area. Six of the 7 patients (85.7%) who required left ventricular assist device survived to hospital discharge. Hospital mortality was 3.7%. In the univariate model, fractional shortening, ejection fraction, and aortic crossclamp time were significantly associated with left ventricular assist device implantation ( P  = .026, .035, .031, respectively). In the multivariate analysis, the aortic crossclamp time was the only significant independent predictor of left ventricular assist device implantation. Aortic crossclamp time and fractional shortening together accounted for 80.9% ( P  &lt; .001) of the variability in left ventricular assist device implantation and constituted the best predictive model: All patients requiring postrepair left ventricular assist device implantation had a fractional shortening less than 20% and an aortic crossclamp time greater than 56 minutes. Conclusions The fractional shortening and aortic crossclamp time together predict 80.9% of the variability in postrepair left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery. When preoperative left ventricular dysfunction is severe (fractional shortening &lt; 20%), an aortic crossclamp time greater than 56 minutes is associated with a substantial risk of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22188820</pmid><doi>10.1016/j.jtcvs.2011.12.004</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cardiology. Vascular system
Cardiopulmonary Bypass
Cardiothoracic Surgery
Chi-Square Distribution
Coronary Vessel Anomalies - mortality
Coronary Vessel Anomalies - surgery
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Female
Heart Function Tests
Heart-Assist Devices
Hospital Mortality
Humans
Infant
Intensive care medicine
Logistic Models
Male
Medical sciences
Pneumology
Predictive Value of Tests
Pulmonary Artery - abnormalities
Retrospective Studies
Sternotomy
Survival Analysis
Treatment Outcome
Ventricular Function, Left
title Prediction of left ventricular assist device implantation after repair of anomalous left coronary artery from the pulmonary artery
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