Highly sensitive troponin T for risk stratification of acutely destabilized heart failure
Background A highly sensitive assay for troponin T (hsTnT) has been recently developed, which allows for the detection of even minor myocardial necrosis with high precision. It remains unexplored whether hsTnT provides incremental prognostic accuracy beyond conventional (c)TnT in patients with acute...
Gespeichert in:
| Veröffentlicht in: | The American heart journal 2012-06, Vol.163 (6), p.1002-1010 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1010 |
|---|---|
| container_issue | 6 |
| container_start_page | 1002 |
| container_title | The American heart journal |
| container_volume | 163 |
| creator | Pascual-Figal, Domingo A., PhD Casas, Teresa, PhD Ordonez-LLanos, Jordi, PhD Manzano-Fernández, Sergio, MD Bonaque, Juan C., MD Boronat, Miguel, MD Muñoz-Esparza, Carmen, MD Valdés, Mariano, PhD Januzzi, James L., MD |
| description | Background A highly sensitive assay for troponin T (hsTnT) has been recently developed, which allows for the detection of even minor myocardial necrosis with high precision. It remains unexplored whether hsTnT provides incremental prognostic accuracy beyond conventional (c)TnT in patients with acutely decompensated heart failure (ADHF). Methods A total of 202 consecutive patients admitted with ADHF and without criteria for acute myocardial infarction were studied. Troponin T was measured using the highly sensitive assay and compared with the conventional method. Patients were clinically followed up at a median of 406 days, with a primary outcome measure of all-cause mortality. Results The high-sensitive assay detected measurable TnT in 98% of patients vs 56% for cTnT; 81% had an hsTnT above the 99th percentile for a healthy reference population, and it reclassified 60% of those with undetectable cTnT. Both TnT methods predicted the risk of death in adjusted multivariable Cox regression analyses, without a superiority of hsTnT over cTnT in the entire population (area under the curve 0.67 vs 0.71, P = .2). Among patients with a cTnT below 0.03 ng/mL (the lowest cut-point with |
| doi_str_mv | 10.1016/j.ahj.2012.03.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1021259132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002870312001810</els_id><sourcerecordid>1021259132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-3be264861931780bc2e351d73cc5e2e559afd81802de1c67f3ae6e70380f343f3</originalsourceid><addsrcrecordid>eNp9klGL1DAUhYMo7rj6A3yRgAi-tN6btGkHYUEWdYUFH1wffAqZ9MZJt9OMSbsw_npTZnRhH3xJCHzncO7JZewlQomA6l1fmm1fCkBRgiwB60dshbBuCtVU1WO2AgBRtA3IM_YspT4_lWjVU3YmRJOxWq7Yjyv_czsceKIx-cnfEZ9i2IfRj_yGuxB59OmWpymayTtv8xlGHhw3dp4o6zpKk9n4wf-mjm_JxIk744c50nP2xJkh0YvTfc6-f_p4c3lVXH_9_OXyw3VhK6WmQm5IqKpVuJbYtLCxgmSNXSOtrUlQXa-N61psQXSEVjVOGlKUZ2rByUo6ec7eHn33Mfyacxy988nSMJiRwpw0gkBRr1GKjL5-gPZhjmNOp7GGSsm2rjBTeKRsDClFcnof_c7EQ7bSS--617l3vfSuQerce9a8OjnPmx11_xR_i87AmxNgkjWDi2a0Pt1zKgcQ1RLx_ZGjXNmdp6iT9TRa6nwkO-ku-P_GuHigtoMf87cNt3SgdD-tTlmjvy0LsuwHCgBsEeQfo7yz1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504638541</pqid></control><display><type>article</type><title>Highly sensitive troponin T for risk stratification of acutely destabilized heart failure</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>ProQuest Central UK/Ireland</source><creator>Pascual-Figal, Domingo A., PhD ; Casas, Teresa, PhD ; Ordonez-LLanos, Jordi, PhD ; Manzano-Fernández, Sergio, MD ; Bonaque, Juan C., MD ; Boronat, Miguel, MD ; Muñoz-Esparza, Carmen, MD ; Valdés, Mariano, PhD ; Januzzi, James L., MD</creator><creatorcontrib>Pascual-Figal, Domingo A., PhD ; Casas, Teresa, PhD ; Ordonez-LLanos, Jordi, PhD ; Manzano-Fernández, Sergio, MD ; Bonaque, Juan C., MD ; Boronat, Miguel, MD ; Muñoz-Esparza, Carmen, MD ; Valdés, Mariano, PhD ; Januzzi, James L., MD</creatorcontrib><description>Background A highly sensitive assay for troponin T (hsTnT) has been recently developed, which allows for the detection of even minor myocardial necrosis with high precision. It remains unexplored whether hsTnT provides incremental prognostic accuracy beyond conventional (c)TnT in patients with acutely decompensated heart failure (ADHF). Methods A total of 202 consecutive patients admitted with ADHF and without criteria for acute myocardial infarction were studied. Troponin T was measured using the highly sensitive assay and compared with the conventional method. Patients were clinically followed up at a median of 406 days, with a primary outcome measure of all-cause mortality. Results The high-sensitive assay detected measurable TnT in 98% of patients vs 56% for cTnT; 81% had an hsTnT above the 99th percentile for a healthy reference population, and it reclassified 60% of those with undetectable cTnT. Both TnT methods predicted the risk of death in adjusted multivariable Cox regression analyses, without a superiority of hsTnT over cTnT in the entire population (area under the curve 0.67 vs 0.71, P = .2). Among patients with a cTnT below 0.03 ng/mL (the lowest cut-point with <10% imprecision; n = 134), solely hsTnT improved the prediction of death over clinical risk factors (relative integrated discrimination improvement +36%, P = .01) and hsTnT above 20 pg/mL identified a significant higher risk of death (hazard ratio 4.7, 95% CI 1.6-13.8, P = .005). Conclusion Among patients with ADHF, myocardial necrosis (as detected with the hsTnT assay) was nearly ubiquitous. The highly sensitive assay for TnT provides comparable prognostic information to cTnT overall, but among those in whom the cTnT method was less precise or frankly negative, the hsTnT assay provided prognostic information.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2012.03.015</identifier><identifier>PMID: 22709753</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Acute coronary syndromes ; Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Family medical history ; Female ; Heart ; Heart attacks ; Heart failure ; Heart Failure - blood ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Humans ; Immunoassay ; Male ; Medical sciences ; Mortality ; Myocardium - pathology ; Necrosis ; Patients ; Population ; Prognosis ; Risk Assessment ; Troponin T - blood</subject><ispartof>The American heart journal, 2012-06, Vol.163 (6), p.1002-1010</ispartof><rights>Mosby, Inc.</rights><rights>2012 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-3be264861931780bc2e351d73cc5e2e559afd81802de1c67f3ae6e70380f343f3</citedby><cites>FETCH-LOGICAL-c466t-3be264861931780bc2e351d73cc5e2e559afd81802de1c67f3ae6e70380f343f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1504638541?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26150242$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22709753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pascual-Figal, Domingo A., PhD</creatorcontrib><creatorcontrib>Casas, Teresa, PhD</creatorcontrib><creatorcontrib>Ordonez-LLanos, Jordi, PhD</creatorcontrib><creatorcontrib>Manzano-Fernández, Sergio, MD</creatorcontrib><creatorcontrib>Bonaque, Juan C., MD</creatorcontrib><creatorcontrib>Boronat, Miguel, MD</creatorcontrib><creatorcontrib>Muñoz-Esparza, Carmen, MD</creatorcontrib><creatorcontrib>Valdés, Mariano, PhD</creatorcontrib><creatorcontrib>Januzzi, James L., MD</creatorcontrib><title>Highly sensitive troponin T for risk stratification of acutely destabilized heart failure</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background A highly sensitive assay for troponin T (hsTnT) has been recently developed, which allows for the detection of even minor myocardial necrosis with high precision. It remains unexplored whether hsTnT provides incremental prognostic accuracy beyond conventional (c)TnT in patients with acutely decompensated heart failure (ADHF). Methods A total of 202 consecutive patients admitted with ADHF and without criteria for acute myocardial infarction were studied. Troponin T was measured using the highly sensitive assay and compared with the conventional method. Patients were clinically followed up at a median of 406 days, with a primary outcome measure of all-cause mortality. Results The high-sensitive assay detected measurable TnT in 98% of patients vs 56% for cTnT; 81% had an hsTnT above the 99th percentile for a healthy reference population, and it reclassified 60% of those with undetectable cTnT. Both TnT methods predicted the risk of death in adjusted multivariable Cox regression analyses, without a superiority of hsTnT over cTnT in the entire population (area under the curve 0.67 vs 0.71, P = .2). Among patients with a cTnT below 0.03 ng/mL (the lowest cut-point with <10% imprecision; n = 134), solely hsTnT improved the prediction of death over clinical risk factors (relative integrated discrimination improvement +36%, P = .01) and hsTnT above 20 pg/mL identified a significant higher risk of death (hazard ratio 4.7, 95% CI 1.6-13.8, P = .005). Conclusion Among patients with ADHF, myocardial necrosis (as detected with the hsTnT assay) was nearly ubiquitous. The highly sensitive assay for TnT provides comparable prognostic information to cTnT overall, but among those in whom the cTnT method was less precise or frankly negative, the hsTnT assay provided prognostic information.</description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Family medical history</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Myocardium - pathology</subject><subject>Necrosis</subject><subject>Patients</subject><subject>Population</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Troponin T - blood</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9klGL1DAUhYMo7rj6A3yRgAi-tN6btGkHYUEWdYUFH1wffAqZ9MZJt9OMSbsw_npTZnRhH3xJCHzncO7JZewlQomA6l1fmm1fCkBRgiwB60dshbBuCtVU1WO2AgBRtA3IM_YspT4_lWjVU3YmRJOxWq7Yjyv_czsceKIx-cnfEZ9i2IfRj_yGuxB59OmWpymayTtv8xlGHhw3dp4o6zpKk9n4wf-mjm_JxIk744c50nP2xJkh0YvTfc6-f_p4c3lVXH_9_OXyw3VhK6WmQm5IqKpVuJbYtLCxgmSNXSOtrUlQXa-N61psQXSEVjVOGlKUZ2rByUo6ec7eHn33Mfyacxy988nSMJiRwpw0gkBRr1GKjL5-gPZhjmNOp7GGSsm2rjBTeKRsDClFcnof_c7EQ7bSS--617l3vfSuQerce9a8OjnPmx11_xR_i87AmxNgkjWDi2a0Pt1zKgcQ1RLx_ZGjXNmdp6iT9TRa6nwkO-ku-P_GuHigtoMf87cNt3SgdD-tTlmjvy0LsuwHCgBsEeQfo7yz1A</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Pascual-Figal, Domingo A., PhD</creator><creator>Casas, Teresa, PhD</creator><creator>Ordonez-LLanos, Jordi, PhD</creator><creator>Manzano-Fernández, Sergio, MD</creator><creator>Bonaque, Juan C., MD</creator><creator>Boronat, Miguel, MD</creator><creator>Muñoz-Esparza, Carmen, MD</creator><creator>Valdés, Mariano, PhD</creator><creator>Januzzi, James L., MD</creator><general>Mosby, Inc</general><general>Mosby</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Highly sensitive troponin T for risk stratification of acutely destabilized heart failure</title><author>Pascual-Figal, Domingo A., PhD ; Casas, Teresa, PhD ; Ordonez-LLanos, Jordi, PhD ; Manzano-Fernández, Sergio, MD ; Bonaque, Juan C., MD ; Boronat, Miguel, MD ; Muñoz-Esparza, Carmen, MD ; Valdés, Mariano, PhD ; Januzzi, James L., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-3be264861931780bc2e351d73cc5e2e559afd81802de1c67f3ae6e70380f343f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Family medical history</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Myocardium - pathology</topic><topic>Necrosis</topic><topic>Patients</topic><topic>Population</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pascual-Figal, Domingo A., PhD</creatorcontrib><creatorcontrib>Casas, Teresa, PhD</creatorcontrib><creatorcontrib>Ordonez-LLanos, Jordi, PhD</creatorcontrib><creatorcontrib>Manzano-Fernández, Sergio, MD</creatorcontrib><creatorcontrib>Bonaque, Juan C., MD</creatorcontrib><creatorcontrib>Boronat, Miguel, MD</creatorcontrib><creatorcontrib>Muñoz-Esparza, Carmen, MD</creatorcontrib><creatorcontrib>Valdés, Mariano, PhD</creatorcontrib><creatorcontrib>Januzzi, James L., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pascual-Figal, Domingo A., PhD</au><au>Casas, Teresa, PhD</au><au>Ordonez-LLanos, Jordi, PhD</au><au>Manzano-Fernández, Sergio, MD</au><au>Bonaque, Juan C., MD</au><au>Boronat, Miguel, MD</au><au>Muñoz-Esparza, Carmen, MD</au><au>Valdés, Mariano, PhD</au><au>Januzzi, James L., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly sensitive troponin T for risk stratification of acutely destabilized heart failure</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>163</volume><issue>6</issue><spage>1002</spage><epage>1010</epage><pages>1002-1010</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background A highly sensitive assay for troponin T (hsTnT) has been recently developed, which allows for the detection of even minor myocardial necrosis with high precision. It remains unexplored whether hsTnT provides incremental prognostic accuracy beyond conventional (c)TnT in patients with acutely decompensated heart failure (ADHF). Methods A total of 202 consecutive patients admitted with ADHF and without criteria for acute myocardial infarction were studied. Troponin T was measured using the highly sensitive assay and compared with the conventional method. Patients were clinically followed up at a median of 406 days, with a primary outcome measure of all-cause mortality. Results The high-sensitive assay detected measurable TnT in 98% of patients vs 56% for cTnT; 81% had an hsTnT above the 99th percentile for a healthy reference population, and it reclassified 60% of those with undetectable cTnT. Both TnT methods predicted the risk of death in adjusted multivariable Cox regression analyses, without a superiority of hsTnT over cTnT in the entire population (area under the curve 0.67 vs 0.71, P = .2). Among patients with a cTnT below 0.03 ng/mL (the lowest cut-point with <10% imprecision; n = 134), solely hsTnT improved the prediction of death over clinical risk factors (relative integrated discrimination improvement +36%, P = .01) and hsTnT above 20 pg/mL identified a significant higher risk of death (hazard ratio 4.7, 95% CI 1.6-13.8, P = .005). Conclusion Among patients with ADHF, myocardial necrosis (as detected with the hsTnT assay) was nearly ubiquitous. The highly sensitive assay for TnT provides comparable prognostic information to cTnT overall, but among those in whom the cTnT method was less precise or frankly negative, the hsTnT assay provided prognostic information.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22709753</pmid><doi>10.1016/j.ahj.2012.03.015</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-8703 |
| ispartof | The American heart journal, 2012-06, Vol.163 (6), p.1002-1010 |
| issn | 0002-8703 1097-6744 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1021259132 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Acute coronary syndromes Aged Biological and medical sciences Cardiology. Vascular system Cardiovascular Cardiovascular disease Family medical history Female Heart Heart attacks Heart failure Heart Failure - blood Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Immunoassay Male Medical sciences Mortality Myocardium - pathology Necrosis Patients Population Prognosis Risk Assessment Troponin T - blood |
| title | Highly sensitive troponin T for risk stratification of acutely destabilized heart failure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T08%3A12%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Highly%20sensitive%20troponin%20T%20for%20risk%20stratification%20of%20acutely%20destabilized%20heart%20failure&rft.jtitle=The%20American%20heart%20journal&rft.au=Pascual-Figal,%20Domingo%20A.,%20PhD&rft.date=2012-06-01&rft.volume=163&rft.issue=6&rft.spage=1002&rft.epage=1010&rft.pages=1002-1010&rft.issn=0002-8703&rft.eissn=1097-6744&rft.coden=AHJOA2&rft_id=info:doi/10.1016/j.ahj.2012.03.015&rft_dat=%3Cproquest_cross%3E1021259132%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1504638541&rft_id=info:pmid/22709753&rft_els_id=S0002870312001810&rfr_iscdi=true |